Podcast
Questions and Answers
What is the target percentage of time in range (TIRp) for glucose concentrations during pregnancy in women with type 1 diabetes?
What is the target percentage of time in range (TIRp) for glucose concentrations during pregnancy in women with type 1 diabetes?
Which of the following is NOT an approach mentioned to reduce the risk of adverse pregnancy outcomes in women with type 1 diabetes?
Which of the following is NOT an approach mentioned to reduce the risk of adverse pregnancy outcomes in women with type 1 diabetes?
What emerging treatment option is being discussed for managing type 1 diabetes during pregnancy?
What emerging treatment option is being discussed for managing type 1 diabetes during pregnancy?
What aspect is highlighted as important for pregnant women with type 1 diabetes besides medical management?
What aspect is highlighted as important for pregnant women with type 1 diabetes besides medical management?
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Why is achieving glucose concentration targets too late in pregnancy considered problematic?
Why is achieving glucose concentration targets too late in pregnancy considered problematic?
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What is the main advantage of semaglutide over liraglutide in terms of weight management?
What is the main advantage of semaglutide over liraglutide in terms of weight management?
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For which age group was semaglutide approved for weight management in 2022?
For which age group was semaglutide approved for weight management in 2022?
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What percentage of total body weight loss did semaglutide achieve in the STEP program at 68 weeks?
What percentage of total body weight loss did semaglutide achieve in the STEP program at 68 weeks?
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What type of side effects are primarily associated with semaglutide?
What type of side effects are primarily associated with semaglutide?
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What structural feature differentiates semaglutide from liraglutide, contributing to its efficacy?
What structural feature differentiates semaglutide from liraglutide, contributing to its efficacy?
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Study Notes
Pre-pregnancy Care, Management, and Technology for Type 1 Diabetes in Pregnancy
- Pre-pregnancy care, gestational weight gain, lifestyle modifications, antihypertensive treatment and low-dose aspirin are crucial to reduce the risk of pre-eclampsia, preterm delivery, and other adverse pregnancy outcomes in pregnancies complicated by type 1 diabetes.
- Target glucose concentrations within range are essential for favorable outcomes.
- Achieving a Time in Range (TIRp) of 3.5–7.8 mmol/L for more than 70% of pregnancy is ideal, however, this is often achieved only in the final weeks, limiting potential benefits.
- Hybrid Closed-Loop (HCL) insulin delivery systems are showing promise as treatment options in pregnancy due to their ability to regulate glucose levels more effectively.
- Effective clinical and psychosocial support is crucial for pregnant women with type 1 diabetes.
- Contemporary studies are actively evaluating the effectiveness of HCL systems in type 1 diabetes during pregnancy.
Semaglutide for Weight Management
- Semaglutide is a long-acting GLP-1 receptor agonist administered weekly via subcutaneous injection.
- Approved for adult weight management in 2021 and for children 12 years and older in 2022.
- Semaglutide is more effective than liraglutide in reducing energy intake, with a 35% reduction compared to liraglutide's 16% reduction.
- Semaglutide also decreases food cravings.
- Semaglutide's enhanced efficacy is attributed to its structural differences with liraglutide, allowing it to target a broader range of GLP-1 receptors.
- In the STEP program, semaglutide demonstrated a weight loss of up to 15% of total body weight after 68 weeks.
- Common adverse effects are gastrointestinal and similar to those associated with other GLP-1 receptor agonists.
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Description
Explore essential practices for managing type 1 diabetes during pregnancy, including lifestyle modifications and antihypertensive treatment. Understand how pre-pregnancy care and technology such as Hybrid Closed-Loop insulin systems can improve outcomes for mothers and babies. Learn about maintaining target glucose concentrations for the best possible results.
