Pre-pregnancy Care for Type 1 Diabetes in Pregnancy

Pre-pregnancy Care, Management, and Technology for Type 1 Diabetes in Pregnancy

• Pre-pregnancy care, gestational weight gain, lifestyle modifications, antihypertensive treatment and low-dose aspirin are crucial to reduce the risk of pre-eclampsia, preterm delivery, and other adverse pregnancy outcomes in pregnancies complicated by type 1 diabetes.
• Target glucose concentrations within range are essential for favorable outcomes.
• Achieving a Time in Range (TIRp) of 3.5–7.8 mmol/L for more than 70% of pregnancy is ideal, however, this is often achieved only in the final weeks, limiting potential benefits.
• Hybrid Closed-Loop (HCL) insulin delivery systems are showing promise as treatment options in pregnancy due to their ability to regulate glucose levels more effectively.
• Effective clinical and psychosocial support is crucial for pregnant women with type 1 diabetes.
• Contemporary studies are actively evaluating the effectiveness of HCL systems in type 1 diabetes during pregnancy.

Semaglutide for Weight Management

• Semaglutide is a long-acting GLP-1 receptor agonist administered weekly via subcutaneous injection.
• Approved for adult weight management in 2021 and for children 12 years and older in 2022.
• Semaglutide is more effective than liraglutide in reducing energy intake, with a 35% reduction compared to liraglutide's 16% reduction.
• Semaglutide also decreases food cravings.
• Semaglutide's enhanced efficacy is attributed to its structural differences with liraglutide, allowing it to target a broader range of GLP-1 receptors.
• In the STEP program, semaglutide demonstrated a weight loss of up to 15% of total body weight after 68 weeks.
• Common adverse effects are gastrointestinal and similar to those associated with other GLP-1 receptor agonists.

Explore essential practices for managing type 1 diabetes during pregnancy, including lifestyle modifications and antihypertensive treatment. Understand how pre-pregnancy care and technology such as Hybrid Closed-Loop insulin systems can improve outcomes for mothers and babies. Learn about maintaining target glucose concentrations for the best possible results.