Post-Translational Modifications Quizzes
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Questions and Answers

What effect can histone methylation have on transcription?

  • Promoting transcription by increasing DNA methylation
  • Repressing transcription by destabilizing chromatin
  • Activating transcription by recruiting specific proteins (correct)
  • Inhibiting transcription by blocking RNA polymerase binding

    • In the NF-KB pathway, what is the role of TRAF3?

  • Promoting the nuclear translocation of NF-KB
  • Inhibiting the degradation of IkB (correct)
  • Enhancing the binding of NF-KB to DNA
  • Activating TAK1 and IKK complexes

    • How do YAP and TAZ contribute to gene expression regulation?

  • Activating genes related to cell growth and survival (correct)
  • Inhibiting cell proliferation pathways
  • Suppressing the activity of transcription factors
  • Promoting apoptosis in damaged cells

    • What is the main function of the Hippo pathway in cellular signaling?

    <p>Inhibiting cell proliferation and promoting tissue homeostasis</p> Signup and view all the answers

    Which type of post-translational modification involves histone methylation?

    <p>Methylation</p> Signup and view all the answers

    What role does Asp 166 play in PKA's catalytic activity?

    <p>Forming hydrogen bonds with protein substrates' hydroxyl groups</p> Signup and view all the answers

    Which statement about intrinsically disordered proteins is correct?

    <p>They have the most free energy and are unstable.</p> Signup and view all the answers

    What is the primary role of protein degradation in normal cellular function?

    <p>All of the above</p> Signup and view all the answers

    Which of the following statements about ubiquitination is correct?

    <p>It involves the formation of an isopeptide bond between ubiquitin and a primary amine.</p> Signup and view all the answers

    What is the primary role of the 26S proteasome in protein degradation?

    <p>Unfolding and degrading ubiquitinated proteins</p> Signup and view all the answers

    Which checkpoint in the cell cycle ensures that all chromosomes are attached to spindles before entering anaphase?

    <p>Checkpoint 3 (Metaphase-Anaphase transition)</p> Signup and view all the answers

    Which of the following statements about aggregated proteins is correct?

    <p>They have lower free energy than correctly folded proteins.</p> Signup and view all the answers

    What is the primary function of post-translational modifications?

    <p>To introduce covalent changes to proteins after translation</p> Signup and view all the answers

    Which of the following post-translational modifications is involved in regulating chromatin structure and gene expression?

    <p>Both methylation and acetylation</p> Signup and view all the answers

    What is the primary function of ubiquitination as a post-translational modification?

    <p>Protein degradation</p> Signup and view all the answers

    Which of the following enzymes is responsible for adding phosphate groups to proteins?

    <p>Kinase</p> Signup and view all the answers

    What is the primary function of histone acetylation in the context of gene regulation?

    <p>Facilitation of transcriptional machinery access</p> Signup and view all the answers

    Which of the following post-translational modifications requires ATP and magnesium ions?

    <p>Phosphorylation</p> Signup and view all the answers

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