18 Questions
What effect can histone methylation have on transcription?
Activating transcription by recruiting specific proteins
In the NF-KB pathway, what is the role of TRAF3?
Inhibiting the degradation of IkB
How do YAP and TAZ contribute to gene expression regulation?
Activating genes related to cell growth and survival
What is the main function of the Hippo pathway in cellular signaling?
Inhibiting cell proliferation and promoting tissue homeostasis
Which type of post-translational modification involves histone methylation?
Methylation
What role does Asp 166 play in PKA's catalytic activity?
Forming hydrogen bonds with protein substrates' hydroxyl groups
Which statement about intrinsically disordered proteins is correct?
They have the most free energy and are unstable.
What is the primary role of protein degradation in normal cellular function?
All of the above
Which of the following statements about ubiquitination is correct?
It involves the formation of an isopeptide bond between ubiquitin and a primary amine.
What is the primary role of the 26S proteasome in protein degradation?
Unfolding and degrading ubiquitinated proteins
Which checkpoint in the cell cycle ensures that all chromosomes are attached to spindles before entering anaphase?
Checkpoint 3 (Metaphase-Anaphase transition)
Which of the following statements about aggregated proteins is correct?
They have lower free energy than correctly folded proteins.
What is the primary function of post-translational modifications?
To introduce covalent changes to proteins after translation
Which of the following post-translational modifications is involved in regulating chromatin structure and gene expression?
Both methylation and acetylation
What is the primary function of ubiquitination as a post-translational modification?
Protein degradation
Which of the following enzymes is responsible for adding phosphate groups to proteins?
Kinase
What is the primary function of histone acetylation in the context of gene regulation?
Facilitation of transcriptional machinery access
Which of the following post-translational modifications requires ATP and magnesium ions?
Phosphorylation
Test your knowledge on covalent modifications to proteins occurring after translation. Questions may cover phosphorylation, methylation, acetylation, ubiquitination, and their impact on protein surface, binding partners, conformations, regulatory mechanisms, and localization.
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