Post-Translational Modifications Quizzes

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Questions and Answers

What effect can histone methylation have on transcription?

  • Promoting transcription by increasing DNA methylation
  • Repressing transcription by destabilizing chromatin
  • Activating transcription by recruiting specific proteins (correct)
  • Inhibiting transcription by blocking RNA polymerase binding

In the NF-KB pathway, what is the role of TRAF3?

  • Promoting the nuclear translocation of NF-KB
  • Inhibiting the degradation of IkB (correct)
  • Enhancing the binding of NF-KB to DNA
  • Activating TAK1 and IKK complexes

How do YAP and TAZ contribute to gene expression regulation?

  • Activating genes related to cell growth and survival (correct)
  • Inhibiting cell proliferation pathways
  • Suppressing the activity of transcription factors
  • Promoting apoptosis in damaged cells

What is the main function of the Hippo pathway in cellular signaling?

<p>Inhibiting cell proliferation and promoting tissue homeostasis (B)</p>
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Which type of post-translational modification involves histone methylation?

<p>Methylation (B)</p>
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What role does Asp 166 play in PKA's catalytic activity?

<p>Forming hydrogen bonds with protein substrates' hydroxyl groups (C)</p>
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Which statement about intrinsically disordered proteins is correct?

<p>They have the most free energy and are unstable. (B)</p>
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What is the primary role of protein degradation in normal cellular function?

<p>All of the above (D)</p>
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Which of the following statements about ubiquitination is correct?

<p>It involves the formation of an isopeptide bond between ubiquitin and a primary amine. (C)</p>
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What is the primary role of the 26S proteasome in protein degradation?

<p>Unfolding and degrading ubiquitinated proteins (C)</p>
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Which checkpoint in the cell cycle ensures that all chromosomes are attached to spindles before entering anaphase?

<p>Checkpoint 3 (Metaphase-Anaphase transition) (C)</p>
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Which of the following statements about aggregated proteins is correct?

<p>They have lower free energy than correctly folded proteins. (B)</p>
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What is the primary function of post-translational modifications?

<p>To introduce covalent changes to proteins after translation (A)</p>
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Which of the following post-translational modifications is involved in regulating chromatin structure and gene expression?

<p>Both methylation and acetylation (B)</p>
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What is the primary function of ubiquitination as a post-translational modification?

<p>Protein degradation (B)</p>
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Which of the following enzymes is responsible for adding phosphate groups to proteins?

<p>Kinase (B)</p>
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What is the primary function of histone acetylation in the context of gene regulation?

<p>Facilitation of transcriptional machinery access (D)</p>
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Which of the following post-translational modifications requires ATP and magnesium ions?

<p>Phosphorylation (A)</p>
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