Post-Translational Modifications Quizzes

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What effect can histone methylation have on transcription?

Promoting transcription by increasing DNA methylation

Repressing transcription by destabilizing chromatin

Activating transcription by recruiting specific proteins (correct)

Inhibiting transcription by blocking RNA polymerase binding

In the NF-KB pathway, what is the role of TRAF3?

Promoting the nuclear translocation of NF-KB

Inhibiting the degradation of IkB (correct)

Enhancing the binding of NF-KB to DNA

Activating TAK1 and IKK complexes

How do YAP and TAZ contribute to gene expression regulation?

Activating genes related to cell growth and survival (correct)

Inhibiting cell proliferation pathways

Suppressing the activity of transcription factors

Promoting apoptosis in damaged cells

What is the main function of the Hippo pathway in cellular signaling?

Inhibiting cell proliferation and promoting tissue homeostasis Signup and view all the answers

Which type of post-translational modification involves histone methylation?

Methylation Signup and view all the answers

What role does Asp 166 play in PKA's catalytic activity?

Forming hydrogen bonds with protein substrates' hydroxyl groups Signup and view all the answers

Which statement about intrinsically disordered proteins is correct?

They have the most free energy and are unstable. Signup and view all the answers

What is the primary role of protein degradation in normal cellular function?

All of the above Signup and view all the answers

Which of the following statements about ubiquitination is correct?

It involves the formation of an isopeptide bond between ubiquitin and a primary amine. Signup and view all the answers

What is the primary role of the 26S proteasome in protein degradation?

Unfolding and degrading ubiquitinated proteins Signup and view all the answers

Which checkpoint in the cell cycle ensures that all chromosomes are attached to spindles before entering anaphase?

Checkpoint 3 (Metaphase-Anaphase transition) Signup and view all the answers

Which of the following statements about aggregated proteins is correct?

They have lower free energy than correctly folded proteins. Signup and view all the answers

What is the primary function of post-translational modifications?

To introduce covalent changes to proteins after translation Signup and view all the answers

Which of the following post-translational modifications is involved in regulating chromatin structure and gene expression?

Both methylation and acetylation Signup and view all the answers

What is the primary function of ubiquitination as a post-translational modification?

Protein degradation Signup and view all the answers

Which of the following enzymes is responsible for adding phosphate groups to proteins?

Kinase Signup and view all the answers

What is the primary function of histone acetylation in the context of gene regulation?

Facilitation of transcriptional machinery access Signup and view all the answers

Which of the following post-translational modifications requires ATP and magnesium ions?

Phosphorylation Signup and view all the answers

Post-Translational Modifications Quizzes

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