Poor Wetting and Solubility of Powders in Pharmacology
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Questions and Answers

What does the melting point of a crystalline solid indicate?

  • The density of the solid material
  • The strength of interactions between molecules in a solid (correct)
  • The external pressure applied to the solid
  • The color of the solid material

How does the heat of fusion relate to the strength of intermolecular forces?

  • Strong forces result in high heat of fusion and high melting point (correct)
  • Strong forces result in low heat of fusion and low melting point
  • Weak forces result in high heat of fusion and high melting point
  • Weak forces result in low heat of fusion and low melting point

How does the energy requirement for disrupting interactions within a solid relate to its melting point?

  • Higher melting point requires less energy
  • Lower melting point requires less energy (correct)
  • Higher melting point requires more energy
  • Lower melting point requires more energy

Why do polymorphic forms have different melting points?

<p>Because they have different molecular forces (B)</p> Signup and view all the answers

What is the heat of fusion?

<p>The energy required to bring about a state change from solid to liquid (D)</p> Signup and view all the answers

How does a crystal bound by weak forces differ from one bound by strong forces?

<p>It has lower heat of fusion and low melting point (D)</p> Signup and view all the answers

What is the process in which a substance forms a solution called?

<p>Dissolution (B)</p> Signup and view all the answers

What property is crucial for a drug to be absorbed at the site of absorption?

<p>Solubility in the fluid (A)</p> Signup and view all the answers

What does the dissolution rate constant 'k' represent in the Noyes-Whitney equation?

<p>Characteristics of each solid drug compound (B)</p> Signup and view all the answers

Which equation defines the rate of solution of solids?

<p>Noyes-Whitney equation (D)</p> Signup and view all the answers

What determines the surface area 'A' of the dissolving solid in the Noyes-Whitney equation?

<p>Particle size (D)</p> Signup and view all the answers

What is crucial for dissolved drug molecules to pass throughout the dissolving fluid to be absorbed?

<p>Contact with absorbing mucosa (D)</p> Signup and view all the answers

What does a contact angle greater than 90° suggest?

<p>Problems are likely during dispersion (C)</p> Signup and view all the answers

How is wettability of powders measured?

<p>By the contact angle of the substance with water (A)</p> Signup and view all the answers

In terms of wetting tendency, what does a smaller contact angle indicate?

<p>Larger wetting tendency (A)</p> Signup and view all the answers

What is solubility defined as?

<p>The amount of drug dissolved in a given volume of a solvent (D)</p> Signup and view all the answers

What enhances solubility of a drug?

<p>Decreased particle size (B)</p> Signup and view all the answers

Why are wetting agents (surfactants) included to improve wettability?

<p>To help in dispersion of hydrophobic drugs (A)</p> Signup and view all the answers

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