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Questions and Answers
What is the primary factor influencing the design of the optimum dosage form for a drug?
What is the primary factor influencing the design of the optimum dosage form for a drug?
- Literature searches in the pre-discovery stage
- Safety and efficacy in human subjects
- Preclinical research results
- Dissolution and absorption of the active pharmaceutical ingredient (API) (correct)
What is the purpose of preformulation studies in drug development?
What is the purpose of preformulation studies in drug development?
- Monitoring adverse reactions in patients
- Assessing short-term side effects of drugs
- Conducting clinical trials on human subjects
- Determining characteristics of active substances and excipients (correct)
In which phase of drug development do safety, efficacy, and monitoring of adverse reactions take place?
In which phase of drug development do safety, efficacy, and monitoring of adverse reactions take place?
- Phase II
- Phase III (correct)
- Pre-discovery stage
- Phase I
What process occurs in the pre-discovery stage of drug development?
What process occurs in the pre-discovery stage of drug development?
What percentage of drugs usually move from Phase II to Phase III of drug development?
What percentage of drugs usually move from Phase II to Phase III of drug development?
Which phase of drug development focuses on determining the safety and dosage of the drug?
Which phase of drug development focuses on determining the safety and dosage of the drug?
What is the purpose of pharmacovigilance in drug development?
What is the purpose of pharmacovigilance in drug development?
What is the key focus of Phase II in drug development?
What is the key focus of Phase II in drug development?
What is the purpose of in-vitro screening in drug development?
What is the purpose of in-vitro screening in drug development?
What is the main purpose of in-vivo screening in drug development?
What is the main purpose of in-vivo screening in drug development?
What needs to be submitted first before proceeding to clinical trials?
What needs to be submitted first before proceeding to clinical trials?
What was given the project code 7901 at the University of the Philippines - College of Pharmacy?
What was given the project code 7901 at the University of the Philippines - College of Pharmacy?
What was lacking in local pharmaceutical companies regarding herbal medicines manufacturing according to the text?
What was lacking in local pharmaceutical companies regarding herbal medicines manufacturing according to the text?
What process must be completed before proceeding to clinical trials?
What process must be completed before proceeding to clinical trials?
Why is amorphous insulin used for rapid onset effects?
Why is amorphous insulin used for rapid onset effects?
Which type of insulin is used for longer duration of action?
Which type of insulin is used for longer duration of action?
What defines amorphous solids?
What defines amorphous solids?
Why is differentiation between crystalline and amorphous solids important for insulin?
Why is differentiation between crystalline and amorphous solids important for insulin?
Why should we ensure the stability of a drug or drug product according to the text?
Why should we ensure the stability of a drug or drug product according to the text?
What role do polymers play in pharmaceutical formulations?
What role do polymers play in pharmaceutical formulations?
How do crystalline insulin and amorphous insulin differ in terms of administration?
How do crystalline insulin and amorphous insulin differ in terms of administration?
Why are amorphous solids easily dissolved in water?
Why are amorphous solids easily dissolved in water?
What ensures that the correct dose and no toxic substances are produced over time according to the text?
What ensures that the correct dose and no toxic substances are produced over time according to the text?
Why is it essential to know the melting points of the polymorphs of cocoa butter?
Why is it essential to know the melting points of the polymorphs of cocoa butter?
What is the significance of cocoa butter melting at normal body temperature?
What is the significance of cocoa butter melting at normal body temperature?
Which characteristic of different polymorphs can significantly affect drug bioavailability and stability?
Which characteristic of different polymorphs can significantly affect drug bioavailability and stability?
Why is the B1 polymorph of cocoa butter considered the best suppository base?
Why is the B1 polymorph of cocoa butter considered the best suppository base?
What is the primary reason for using cocoa butter as a suppository base?
What is the primary reason for using cocoa butter as a suppository base?
How does knowing the melting points aid in selecting polymorphs for formulation?
How does knowing the melting points aid in selecting polymorphs for formulation?
In what way can different polymorphs affect drug bioavailability?
In what way can different polymorphs affect drug bioavailability?
What factor makes B1 polymorph ideal to prevent suppositories from melting in one's hands?
What factor makes B1 polymorph ideal to prevent suppositories from melting in one's hands?
Why is it important to add as few ingredients as possible when formulating suspensions?
Why is it important to add as few ingredients as possible when formulating suspensions?
In the context of pharmaceutical formulations, why is cost-effectiveness a critical factor when selecting excipients for an API?
In the context of pharmaceutical formulations, why is cost-effectiveness a critical factor when selecting excipients for an API?
What is the primary purpose of dissolution testing in pharmaceuticals?
What is the primary purpose of dissolution testing in pharmaceuticals?
How does selecting a suitable excipient for an API contribute to ensuring drug stability?
How does selecting a suitable excipient for an API contribute to ensuring drug stability?
Why is it important to consider a solvent's ability to dissolve an API when formulating pharmaceuticals?
Why is it important to consider a solvent's ability to dissolve an API when formulating pharmaceuticals?
How does an increase in wettability of particles affect dissolution rate?
How does an increase in wettability of particles affect dissolution rate?
What role do bigger pores play in the dissolution process?
What role do bigger pores play in the dissolution process?
How do particle size and surface area correlate with dissolution rate?
How do particle size and surface area correlate with dissolution rate?
Which API property directly influences dissolution rate?
Which API property directly influences dissolution rate?
How does the biological fluid system pH affect dissolution rate?
How does the biological fluid system pH affect dissolution rate?
What is the main concern when dealing with saturated solutions and the solubility of APIs?
What is the main concern when dealing with saturated solutions and the solubility of APIs?
In pharmaceutical formulation, why is it crucial to combine oil-soluble ingredients with oil and water-soluble ingredients with water?
In pharmaceutical formulation, why is it crucial to combine oil-soluble ingredients with oil and water-soluble ingredients with water?
What factor does not contribute to the Absolute (Intrinsic) Solubility of a drug compound?
What factor does not contribute to the Absolute (Intrinsic) Solubility of a drug compound?
Why is it important to consider intermolecular forces of attraction (IMFAs) when formulating dosage forms?
Why is it important to consider intermolecular forces of attraction (IMFAs) when formulating dosage forms?
What term describes the point at which an API starts to precipitate due to exceeding its solubility in a solution?
What term describes the point at which an API starts to precipitate due to exceeding its solubility in a solution?
What is a key consideration when dealing with drug dissolution?
What is a key consideration when dealing with drug dissolution?
Why is it important to avoid precipitation of ingredients in a solution?
Why is it important to avoid precipitation of ingredients in a solution?
What relationship does calcium compounds exhibit between solubility and temperature?
What relationship does calcium compounds exhibit between solubility and temperature?
Why is understanding the crystal form (amorphous vs crystalline) important in drug release?
Why is understanding the crystal form (amorphous vs crystalline) important in drug release?
In terms of stability, why are some solutions temperature-dependent in their solubility?
In terms of stability, why are some solutions temperature-dependent in their solubility?
Why is it crucial for excipients to be physiologically inert?
Why is it crucial for excipients to be physiologically inert?
Which property of excipients is essential to prevent microorganism contamination in pharmaceutical formulations?
Which property of excipients is essential to prevent microorganism contamination in pharmaceutical formulations?
How does the presence of certain excipients influence drug bioavailability?
How does the presence of certain excipients influence drug bioavailability?
What role do excipients play in ensuring the stability of a drug product over time?
What role do excipients play in ensuring the stability of a drug product over time?
Why must excipients be compatible with the active pharmaceutical ingredient (API)?
Why must excipients be compatible with the active pharmaceutical ingredient (API)?
What is the key factor influencing the partitioning of drugs across membranes?
What is the key factor influencing the partitioning of drugs across membranes?
Which statement best describes the concept of polymorphism in pharmaceutical compounds?
Which statement best describes the concept of polymorphism in pharmaceutical compounds?
How does the presence of preservatives in emulsions relate to drug stability?
How does the presence of preservatives in emulsions relate to drug stability?
What role do weak electrolytes play in the partitioning process between two immiscible liquids?
What role do weak electrolytes play in the partitioning process between two immiscible liquids?
Why is understanding the difference between crystalline and amorphous solids crucial for drug formulation?
Why is understanding the difference between crystalline and amorphous solids crucial for drug formulation?
What is the primary purpose of providing an enteric-coated layer to a dosage form?
What is the primary purpose of providing an enteric-coated layer to a dosage form?
How does solubility affect the bioavailability of a drug?
How does solubility affect the bioavailability of a drug?
In pharmaceutical formulations, what role do excipients play?
In pharmaceutical formulations, what role do excipients play?
Which factor determines the partition coefficient of a drug between two immiscible phases?
Which factor determines the partition coefficient of a drug between two immiscible phases?
What is a key concern when determining drug stability under different conditions?
What is a key concern when determining drug stability under different conditions?
Which property of excipients is essential for ensuring proper dissolution and absorption of the active pharmaceutical ingredient (API)?
Which property of excipients is essential for ensuring proper dissolution and absorption of the active pharmaceutical ingredient (API)?
Why is it important to address concerns related to drug stability in formulation development?
Why is it important to address concerns related to drug stability in formulation development?
How does partitioning affect the distribution of a drug within the body?
How does partitioning affect the distribution of a drug within the body?
What effect does crystal form have on the dissolution rate of a drug?
What effect does crystal form have on the dissolution rate of a drug?
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