Poliovirus Quiz
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Questions and Answers

What is the characteristic of the Poliovirus genome?

  • Positive sense RNA (correct)
  • Double-stranded DNA
  • Single-stranded DNA
  • Negative sense RNA
  • What is the primary site of Poliovirus replication?

  • Peyer's patches in the submucosa of the ileum (correct)
  • Lymphoid tissues in the spleen
  • Epithelial cells of the intestinal tract
  • Anterior horn of lower motor neuron cell bodies
  • What is the mode of transmission of Poliovirus?

  • Fecal-oral transmission (correct)
  • Vector-borne transmission
  • Direct contact transmission
  • Airborne transmission
  • What is the characteristic of the Salk vaccine?

    <p>Killed vaccine that induces IgG</p> Signup and view all the answers

    What is the effect of Poliovirus infection on the lower motor neuron cell bodies?

    <p>Infection of the anterior horn causing paralysis</p> Signup and view all the answers

    What is the characteristic of Poliovirus infection in the muscles?

    <p>Asymmetric paralysis concentrated in the lower legs</p> Signup and view all the answers

    What is the complication of Poliovirus infection?

    <p>Aseptic meningitis</p> Signup and view all the answers

    Where does Poliovirus replicate in the human body?

    <p>In the submucosa of the ileum</p> Signup and view all the answers

    What type of RNA virus is Poliovirus?

    <p>Positive sense RNA virus</p> Signup and view all the answers

    What is the mode of transmission of Poliovirus?

    <p>Through contaminated food and water</p> Signup and view all the answers

    What type of vaccine is Sabin vaccine?

    <p>Live and attenuated vaccine</p> Signup and view all the answers

    What is the characteristic of Poliovirus infection?

    <p>It causes an asymmetric paralysis</p> Signup and view all the answers

    What is a common complication of Poliovirus infection?

    <p>Aseptic meningitis</p> Signup and view all the answers

    What is the effect of Poliovirus infection on the diaphragm?

    <p>It causes paralysis of the diaphragm</p> Signup and view all the answers

    Study Notes

    Poliovirus Characteristics

    • Poliovirus is a positive sense RNA virus.
    • It is a naked virus, meaning it lacks an envelope.

    Transmission and Replication

    • Poliovirus is transmitted via the fecal-oral route, making it acid labile.
    • The virus replicates in Peyer's patches, which are found in the submucosa of the ileum.
    • Replication occurs in 2-3 weeks.

    Effects on the Nervous System

    • Poliovirus infection can lead to paralysis, particularly in the lower motor neurons.
    • The virus can infect the anterior horn of lower motor neuron cell bodies, causing paralysis.
    • The resulting paralysis is often asymmetric, affecting the lower legs, and can also lead to myalgia and respiratory deficiency due to diaphragm paralysis.

    Vaccines

    • There are two types of poliovirus vaccines: killed and live attenuated.
    • Killed vaccines, like Salk, bypass the GI tract and only elicit IgG antibodies, not IgA.
    • Live attenuated vaccines, like Sabin, go through the stomach mucosa and stimulate IgA production.

    General Facts

    • All enteroviruses, except rhinovirus, are transmitted via the fecal-oral route.
    • Poliovirus replicates in lymphoid tissues.

    Poliovirus Characteristics

    • Poliovirus is a positive sense RNA virus.
    • It is a naked virus, meaning it lacks an envelope.

    Transmission and Replication

    • Poliovirus is transmitted via the fecal-oral route, making it acid labile.
    • The virus replicates in Peyer's patches, which are found in the submucosa of the ileum.
    • Replication occurs in 2-3 weeks.

    Effects on the Nervous System

    • Poliovirus infection can lead to paralysis, particularly in the lower motor neurons.
    • The virus can infect the anterior horn of lower motor neuron cell bodies, causing paralysis.
    • The resulting paralysis is often asymmetric, affecting the lower legs, and can also lead to myalgia and respiratory deficiency due to diaphragm paralysis.

    Vaccines

    • There are two types of poliovirus vaccines: killed and live attenuated.
    • Killed vaccines, like Salk, bypass the GI tract and only elicit IgG antibodies, not IgA.
    • Live attenuated vaccines, like Sabin, go through the stomach mucosa and stimulate IgA production.

    General Facts

    • All enteroviruses, except rhinovirus, are transmitted via the fecal-oral route.
    • Poliovirus replicates in lymphoid tissues.

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    Description

    This quiz covers the characteristics and transmission of poliovirus, including its RNA structure, replication, and effects on the body.

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