14 Questions
What is the characteristic of the Poliovirus genome?
Positive sense RNA
What is the primary site of Poliovirus replication?
Peyer's patches in the submucosa of the ileum
What is the mode of transmission of Poliovirus?
Fecal-oral transmission
What is the characteristic of the Salk vaccine?
Killed vaccine that induces IgG
What is the effect of Poliovirus infection on the lower motor neuron cell bodies?
Infection of the anterior horn causing paralysis
What is the characteristic of Poliovirus infection in the muscles?
Asymmetric paralysis concentrated in the lower legs
What is the complication of Poliovirus infection?
Aseptic meningitis
Where does Poliovirus replicate in the human body?
In the submucosa of the ileum
What type of RNA virus is Poliovirus?
Positive sense RNA virus
What is the mode of transmission of Poliovirus?
Through contaminated food and water
What type of vaccine is Sabin vaccine?
Live and attenuated vaccine
What is the characteristic of Poliovirus infection?
It causes an asymmetric paralysis
What is a common complication of Poliovirus infection?
Aseptic meningitis
What is the effect of Poliovirus infection on the diaphragm?
It causes paralysis of the diaphragm
Study Notes
Poliovirus Characteristics
- Poliovirus is a positive sense RNA virus.
- It is a naked virus, meaning it lacks an envelope.
Transmission and Replication
- Poliovirus is transmitted via the fecal-oral route, making it acid labile.
- The virus replicates in Peyer's patches, which are found in the submucosa of the ileum.
- Replication occurs in 2-3 weeks.
Effects on the Nervous System
- Poliovirus infection can lead to paralysis, particularly in the lower motor neurons.
- The virus can infect the anterior horn of lower motor neuron cell bodies, causing paralysis.
- The resulting paralysis is often asymmetric, affecting the lower legs, and can also lead to myalgia and respiratory deficiency due to diaphragm paralysis.
Vaccines
- There are two types of poliovirus vaccines: killed and live attenuated.
- Killed vaccines, like Salk, bypass the GI tract and only elicit IgG antibodies, not IgA.
- Live attenuated vaccines, like Sabin, go through the stomach mucosa and stimulate IgA production.
General Facts
- All enteroviruses, except rhinovirus, are transmitted via the fecal-oral route.
- Poliovirus replicates in lymphoid tissues.
Poliovirus Characteristics
- Poliovirus is a positive sense RNA virus.
- It is a naked virus, meaning it lacks an envelope.
Transmission and Replication
- Poliovirus is transmitted via the fecal-oral route, making it acid labile.
- The virus replicates in Peyer's patches, which are found in the submucosa of the ileum.
- Replication occurs in 2-3 weeks.
Effects on the Nervous System
- Poliovirus infection can lead to paralysis, particularly in the lower motor neurons.
- The virus can infect the anterior horn of lower motor neuron cell bodies, causing paralysis.
- The resulting paralysis is often asymmetric, affecting the lower legs, and can also lead to myalgia and respiratory deficiency due to diaphragm paralysis.
Vaccines
- There are two types of poliovirus vaccines: killed and live attenuated.
- Killed vaccines, like Salk, bypass the GI tract and only elicit IgG antibodies, not IgA.
- Live attenuated vaccines, like Sabin, go through the stomach mucosa and stimulate IgA production.
General Facts
- All enteroviruses, except rhinovirus, are transmitted via the fecal-oral route.
- Poliovirus replicates in lymphoid tissues.
This quiz covers the characteristics and transmission of poliovirus, including its RNA structure, replication, and effects on the body.
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