Untitled Quiz

<p>Produce more predictable color outcomes (A)</p> Signup and view all the answers

<p>Provide more pastel colors and increase film coverage (C)</p> Signup and view all the answers

<p>Low molecular weight polyethylene glycol (D)</p> Signup and view all the answers

<p>They decrease molecular rigidity and increase flexibility (A)</p> Signup and view all the answers

<p>They can mask the color of the tablet core (C)</p> Signup and view all the answers

<p>Color of the coating (C)</p> Signup and view all the answers

<p>They allow polymers to become more flexible (B)</p> Signup and view all the answers

<p>To avoid a mottled appearance in the final product (D)</p> Signup and view all the answers

<p>Carnauba wax (A), Beeswax (C)</p> Signup and view all the answers

<p>It provides a sweeter taste (D)</p> Signup and view all the answers

<p>Uneven drying time resulting in rough tablets (D)</p> Signup and view all the answers

<p>The pan shape, load, and rotational speed (B)</p> Signup and view all the answers

<p>The tablets must possess proper physical strength. (C)</p> Signup and view all the answers

<p>Consistently intact tablet shapes without defects. (B)</p> Signup and view all the answers

<p>Film coating materials. (B)</p> Signup and view all the answers

<p>They typically become rough in the early phases of coating. (C)</p> Signup and view all the answers

<p>Tablet size for easy handling. (C)</p> Signup and view all the answers

<p>They may cause the surfaces to soften. (A)</p> Signup and view all the answers

<p>To withstand mechanical stress from other tablets and equipment. (A)</p> Signup and view all the answers

<p>Sphere (D)</p> Signup and view all the answers

<p>It forms lumps and glues together (D)</p> Signup and view all the answers

<p>Ability to change with aging (C)</p> Signup and view all the answers

<p>To ensure proper wetting of the tablet surface (B)</p> Signup and view all the answers

<p>They must aesthetically enhance the product (B)</p> Signup and view all the answers

<p>They tend to solubilize in the GI tract (C)</p> Signup and view all the answers

<p>They should exhibit full compatibility (C)</p> Signup and view all the answers

<p>Surface hydrophobicity/hydrophilicity matching (D)</p> Signup and view all the answers

<p>It prevents drug release interference (C)</p> Signup and view all the answers

<p>It can incorporate color and other additives without difficulty. (B)</p> Signup and view all the answers

<p>It can cause bridging and filling of debossed tablet surfaces. (D)</p> Signup and view all the answers

<p>It is soluble in organic solvents but not in water. (C)</p> Signup and view all the answers

<p>It has good solubility in water. (A)</p> Signup and view all the answers

<p>To protect the drug from stomach enzymes. (D)</p> Signup and view all the answers

<p>Bridging of tablet surfaces. (A)</p> Signup and view all the answers

<p>It can fill debossed surfaces on tablets. (B)</p> Signup and view all the answers

<p>Cellulose Acetate Phthalate. (B)</p> Signup and view all the answers

<p>Ability to incorporate additives seamlessly. (C)</p> Signup and view all the answers

A process involving three main parts: tablet properties, coating compositions, and coating processes, to coat tablets.

Tablet shape crucial for withstanding coating process stresses and maintaining integrity during coating.

Factors like strength, stability, and resistance to mechanical stress that affect the tablet's ability to withstand the coating process.

Tablets must have an intact shape and no imperfections to maintain integrity during coating.

Substances used in coating tablets, including solvents, plasticizers, colorants, and opaquants, which affect coating and protection.

Important and desirable characteristics for tablets to endure the coating process, including strength and shape integrity

Tablets that become rough in the coating process due to sensitivity to heat and coating materials, and thus are unacceptable for film coating.

The process of applying a thin, protective layer to tablets, usually for taste masking, controlled release, or improved appearance.

Square tablets tend to stick together during coating because coating materials collect between the flat surfaces.

The tablet's surface must be compatible with the coating material to ensure proper adhesion and wetting.

Surfactants are added to coating solutions to improve the wetting of the tablet surface by the coating material.

Polymers that are used to create the protective film coating around the tablet.

These materials dissolve in the GI tract, releasing the drug quickly.

Coating materials should be soluble, aesthetically pleasing, stable, tasteless, and non-toxic.

Coating materials should be strong enough to prevent cracking or chipping to ensure prolonged effectiveness.

Hydroxypropyl methylcellulose (HPMC) is a versatile coating material used for air suspension and pan-spray coating. It offers good solubility in organic and aqueous solvents, doesn't interfere with drug release, and is flexible, tasteless, and odorless.

HPMC, when used alone, can bridge and fill in the grooves of tablets. This can lead to uneven coatings and challenges.

Ethyl Cellulose (EC) is a coating material completely insoluble in water and stomach fluids. It's often mixed with water-soluble polymers like HPMC to control water solubility.

Enteric coatings are designed to protect the drug from the stomach's acidic environment or to protect the stomach from the drug itself.

Enteric materials, like HPMCP, Cellulose Acetate Phthalate, and Acrylate Polymers, dissolve at different pH levels within the gastrointestinal tract.

HPMC excels as a tablet coating due to its solubility in organic and water-based solvents, non interference with drug release, flexibility, lack of taste and odor, and stability in different conditions.

Ethyl Cellulose (EC) is non-toxic, colorless, odorless, and tasteless, and is stable in most environments.

Ethyl Cellulose (EC) can be brittle without plasticizers.

Enteric coating can protect the drug from stomach enzymes, protect the stomach from harsh drugs, or allow for controlled drug release in the gut.

Hydroxypropyl Methyl Cellulose Phthalate (HPMCP) is an enteric coating material that is soluble in the higher pH environment of the intestines, but not in the acidic stomach.

A substance added to coating solutions to make the film flexible and improve its adhesion to the tablet.

Plasticizers decrease the rigidity of the polymer, allowing the coating film to bend and conform to the tablet surface.

Without a plasticizer, the coating film would be too brittle and might crack or peel off the tablet.

Examples include polyethylene glycol (PEG), Tweens, and Spans, these help to make the coating flexible and allow it to adhere well to the tablet.

Examples include castor oil and Spans, these are used when the solvent used is not water.

These are colored pigments used in tablet coatings.

Opaquants are fine powders that help to create a more pastel color and improve the coverage of the coating.

Opaquants are cheaper than colorants and can be used to reduce the amount of colorant needed in the coating solution.

This is the most common opaquant used in tablet coatings.

Lakes pigments are preferred because they provide consistent, evenly distributed color, ensuring a more reproducible coating for each tablet.

The first syrup coats applied in tablet coating, often containing suspended powders.

Premature color addition to rough tablets can create a mottled, uneven appearance in the final tablet.

Applying a few clear syrup coats to provide a smooth, even surface.

Achieving the desired shine (luster) by using waxes like beeswax or carnauba wax.

It's faster, more economical, and offers flexibility with film-forming polymers.