Platelets and Hemostasis
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Questions and Answers

Which of the following can activate platelets?

  • Endothelial injury (correct)
  • Hemostasis
  • Blood clotting
  • Inflammation
  • What is the main function of platelets in hemostasis?

  • To seal damaged vessels (correct)
  • To prevent blood clotting
  • To circulate in an inactive form
  • To stimulate other platelets
  • What can cause platelets to activate?

  • Circulation in an inactive form
  • Activation by other activated platelets (correct)
  • Prevention of blood clotting
  • Inflammation
  • Which cells synthesize Von Willebrand Factor (vWF)?

    <p>Endothelial cells</p> Signup and view all the answers

    Where is Von Willebrand Factor (vWF) stored in endothelial cells?

    <p>Weibel-Palade bodies</p> Signup and view all the answers

    What is the main function of platelets in hemostasis?

    <p>Seal openings in vascular tree</p> Signup and view all the answers

    True or false: Platelets adhere to the sub-endothelium during hemostasis?

    <p>True</p> Signup and view all the answers

    True or false: Platelet aggregation involves the binding of platelets to each other?

    <p>True</p> Signup and view all the answers

    True or false: Von Willebrand Factor (vWF) is released by activated platelets and endothelial cells?

    <p>True</p> Signup and view all the answers

    True or false: Von Willebrand Factor (vWF) is a carrier protein for factor VIII?

    <p>True</p> Signup and view all the answers

    True or false: Von Willebrand Factor (vWF) binds platelets to damaged endothelium?

    <p>True</p> Signup and view all the answers

    True or false: Von Willebrand Factor (vWF) binds activated platelets together (aggregation)?

    <p>True</p> Signup and view all the answers

    True or false: Von Willebrand Factor (vWF) acts as a carrier protein for factor VIII?

    <p>True</p> Signup and view all the answers

    True or false: Von Willebrand Factor (vWF) binds platelets to damaged endothelium?

    <p>True</p> Signup and view all the answers

    True or false: Von Willebrand Factor (vWF) binds activated platelets together for aggregation?

    <p>True</p> Signup and view all the answers

    Which factor is released in the presence of thrombin?

    <p>Factor VIII</p> Signup and view all the answers

    What is the role of Von Willebrand Factor (vWF) in hemostasis?

    <p>It binds activated platelets together for aggregation</p> Signup and view all the answers

    What is the function of Von Willebrand Factor (vWF) in platelet adhesion?

    <p>It binds platelets to damaged endothelium</p> Signup and view all the answers

    Which of the following is true about membrane glycoproteins?

    <p>They are made up of amino acids and glucose molecules</p> Signup and view all the answers

    What is the role of GPIb in platelet adhesion?

    <p>It binds to vWF</p> Signup and view all the answers

    What binds to subendothelial collagen during hemostasis?

    <p>vWF</p> Signup and view all the answers

    Which receptor is the most abundant on platelets' surface?

    <p>GPIIb/IIIa receptor</p> Signup and view all the answers

    What happens to the GPIIb/IIIa receptor during platelet activation?

    <p>It changes conformation</p> Signup and view all the answers

    When does the GPIIb/IIIa receptor bind?

    <p>When platelets are activated</p> Signup and view all the answers

    Which protein does GPIIb/IIIa bind to in order to link platelets together?

    <p>Fibrinogen</p> Signup and view all the answers

    What is the basis for IIB/IIIA receptor blocking drugs?

    <p>Platelet aggregation</p> Signup and view all the answers

    What is the main function of GPIIb/IIIa receptor in platelet aggregation?

    <p>Linking platelets together</p> Signup and view all the answers

    Which type of platelet granules is the most abundant?

    <p>Alpha granules</p> Signup and view all the answers

    Which substances are released from alpha granules upon platelet activation?

    <p>Fibrinogen, von Willebrand factor, and platelet factor 4</p> Signup and view all the answers

    What stimulates platelet activation and secretion of stored activators?

    <p>Stimulation by activating substances</p> Signup and view all the answers

    Which protein is released from alpha granules and binds to endothelial cells?

    <p>Platelet Factor 4 (PF4)</p> Signup and view all the answers

    What is the rare, life-threatening effect of heparin administration?

    <p>Heparin-induced thrombocytopenia</p> Signup and view all the answers

    What happens when antibodies bind to PF4 complexed with heparin?

    <p>Platelet activation</p> Signup and view all the answers

    Which receptors does Adenosine Diphosphate (ADP) bind to on platelets?

    <p>P2Y1 and P2Y12</p> Signup and view all the answers

    Which of the following drugs inhibit platelet activity by blocking ADP receptors?

    <p>Clopidogrel, prasugrel, ticlopidine, ticagrelor</p> Signup and view all the answers

    Which molecule is a powerful platelet activator and has receptors on platelets?

    <p>Thromboxane A2 (TXA2)</p> Signup and view all the answers

    Which test involves making a small cut to the patient's arm and applying/removing filter paper until bleeding stops?

    <p>Bleeding Time Test</p> Signup and view all the answers

    What is the purpose of the Bleeding Time Test?

    <p>To measure platelet function</p> Signup and view all the answers

    Is the Bleeding Time Test commonly performed in the modern era?

    <p>No, it is rarely done</p> Signup and view all the answers

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