Podcast
Questions and Answers
What is the primary function of VWF in platelet activation?
What is the primary function of VWF in platelet activation?
- Adheres to the injured site (correct)
- Raises the affinity of integrin α2β1 for collagen
- Releases TXA2 and ADP
- Triggers inside-out reaction
Which receptor is responsible for triggering internal platelet activation pathways?
Which receptor is responsible for triggering internal platelet activation pathways?
- GP VI (correct)
- α2β1
- GP Ib/IX/V
- P2Y1
What is the role of TXA2 and ADP in platelet activation?
What is the role of TXA2 and ADP in platelet activation?
- Initiate GP VI receptor activation
- Trigger outside-in reaction (correct)
- Anchor platelet to damaged surface
- Raise affinity of α2β1 for collagen
Which molecule causes the platelet to lose its discoid shape and spread on the damaged surface?
Which molecule causes the platelet to lose its discoid shape and spread on the damaged surface?
What is the role of TXA2 and ADP in platelet activation?
What is the role of TXA2 and ADP in platelet activation?
Which receptor site is integral for fibrinogen binding during platelet aggregation?
Which receptor site is integral for fibrinogen binding during platelet aggregation?
In platelet aggregation, where do phospholipids redeploy with more polar molecules?
In platelet aggregation, where do phospholipids redeploy with more polar molecules?
Which molecule promotes platelet-to-platelet aggregation by binding to RGD sequences of fibrinogen and VWF?
Which molecule promotes platelet-to-platelet aggregation by binding to RGD sequences of fibrinogen and VWF?
What triggers the activation of platelets, leading to the release of granular contents?
What triggers the activation of platelets, leading to the release of granular contents?
Which of the following is a key part of primary hemostasis involving platelet aggregation?
Which of the following is a key part of primary hemostasis involving platelet aggregation?
What is the pathological basis for arterial thrombotic events like acute myocardial infarction and strokes?
What is the pathological basis for arterial thrombotic events like acute myocardial infarction and strokes?
Which process involves the combination of polar phospholipid exposure on activated platelets and platelet fragmentation?
Which process involves the combination of polar phospholipid exposure on activated platelets and platelet fragmentation?
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