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Platelet Function Process

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Questions and Answers

What is the primary function of VWF in platelet activation?

Adheres to the injured site (correct)

Raises the affinity of integrin α2β1 for collagen

Releases TXA2 and ADP

Triggers inside-out reaction

Which receptor is responsible for triggering internal platelet activation pathways?

GP VI (correct)

α2β1

GP Ib/IX/V

P2Y1

What is the role of TXA2 and ADP in platelet activation?

Initiate GP VI receptor activation

Trigger outside-in reaction (correct)

Anchor platelet to damaged surface

Raise affinity of α2β1 for collagen

Which molecule causes the platelet to lose its discoid shape and spread on the damaged surface?

α2β1 Signup and view all the answers

What is the role of TXA2 and ADP in platelet activation?

Activating neighboring platelets through their respective receptors Signup and view all the answers

Which receptor site is integral for fibrinogen binding during platelet aggregation?

Integrin αIIbβ3 Signup and view all the answers

In platelet aggregation, where do phospholipids redeploy with more polar molecules?

Outer layer of the membrane Signup and view all the answers

Which molecule promotes platelet-to-platelet aggregation by binding to RGD sequences of fibrinogen and VWF?

Thromboxane A2 Signup and view all the answers

What triggers the activation of platelets, leading to the release of granular contents?

Ligand binding to integrins Signup and view all the answers

Which of the following is a key part of primary hemostasis involving platelet aggregation?

White clot formation Signup and view all the answers

What is the pathological basis for arterial thrombotic events like acute myocardial infarction and strokes?

Inappropriate platelet activation leading to white clots Signup and view all the answers

Which process involves the combination of polar phospholipid exposure on activated platelets and platelet fragmentation?

Secondary hemostasis Signup and view all the answers

Platelet Function Process

Choose a study mode

Podcast

Questions and Answers

What is the primary function of VWF in platelet activation?

Which receptor is responsible for triggering internal platelet activation pathways?

What is the role of TXA2 and ADP in platelet activation?

Which molecule causes the platelet to lose its discoid shape and spread on the damaged surface?

What is the role of TXA2 and ADP in platelet activation?

Which receptor site is integral for fibrinogen binding during platelet aggregation?

In platelet aggregation, where do phospholipids redeploy with more polar molecules?

Which molecule promotes platelet-to-platelet aggregation by binding to RGD sequences of fibrinogen and VWF?

What triggers the activation of platelets, leading to the release of granular contents?

Which of the following is a key part of primary hemostasis involving platelet aggregation?

What is the pathological basis for arterial thrombotic events like acute myocardial infarction and strokes?

Which process involves the combination of polar phospholipid exposure on activated platelets and platelet fragmentation?

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