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Platelet Production Inhibitors and Cytokines/Hormones Involved in Platelet Production Quiz

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Platelet Production Inhibitors and Cytokines/Hormones Involved in Platelet Production Quiz

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Questions and Answers

What is the average diameter of platelets?

4.5 um

3.5 um

2.5 um (correct)

1.5 um

How do circulating, resting platelets behave upon exposure to EDTA?

Remain unchanged

Shrink in size

Expand in size

Round up (correct)

Where do platelets cluster with erythrocytes in the blood vessel?

Near the endothelium

In the vein

Near the center (correct)

At the periphery

How do platelets appear on a Wright-stained wedge preparation blood film?

Circular and lavender Signup and view all the answers

What is the normal platelet count in the peripheral blood?

150 to 450 X 10^9/L Signup and view all the answers

What happens to sequestered platelets in times of demand?

They are released into circulation Signup and view all the answers

What is the primary function of platelets when there is hemostatic need?

Adhering to neighboring structures Signup and view all the answers

What distinguishes reticulated platelets from ordinary mature circulating platelets?

They have a larger mean platelet volume (MPV) Signup and view all the answers

What is the diameter of reticulated platelets in peripheral blood films?

6 um or greater Signup and view all the answers

How do reticulated platelets appear in EDTA?

Round up Signup and view all the answers

Under steady-state conditions, what is the rate of platelet release from megakaryocytes equal to?

Rate of platelet removal from circulation Signup and view all the answers

What is the estimated platelet turnover rate under healthy steady-state conditions?

~35,000 platelets/mL/day Signup and view all the answers

How many platelets can a single megakaryocyte shed during the process known as thrombopoiesis?

2000 to 4000 platelets Signup and view all the answers

What is the average total turnover rate of platelets in the body per day?

8 to 9 days Signup and view all the answers

Which hormone or cytokine has shown synergistic interaction with thrombopoietin (TPO) and IL-3?

IL-6 Signup and view all the answers

What is the role of marrow macrophages in relation to thrombopoiesis?

They aid in platelet shedding Signup and view all the answers

Which cytokine is NOT listed as having a synergistic interaction with TPO and IL-3 in platelet production?

EPO Signup and view all the answers

What is the approximate number of megakaryocytes involved in producing platelets per day?

$10^8$ Signup and view all the answers