18 Questions
What is the average diameter of platelets?
2.5 um
How do circulating, resting platelets behave upon exposure to EDTA?
Round up
Where do platelets cluster with erythrocytes in the blood vessel?
Near the center
How do platelets appear on a Wright-stained wedge preparation blood film?
Circular and lavender
What is the normal platelet count in the peripheral blood?
150 to 450 X 10^9/L
What happens to sequestered platelets in times of demand?
They are released into circulation
What is the primary function of platelets when there is hemostatic need?
Adhering to neighboring structures
What distinguishes reticulated platelets from ordinary mature circulating platelets?
They have a larger mean platelet volume (MPV)
What is the diameter of reticulated platelets in peripheral blood films?
6 um or greater
How do reticulated platelets appear in EDTA?
Round up
Under steady-state conditions, what is the rate of platelet release from megakaryocytes equal to?
Rate of platelet removal from circulation
What is the estimated platelet turnover rate under healthy steady-state conditions?
~35,000 platelets/mL/day
How many platelets can a single megakaryocyte shed during the process known as thrombopoiesis?
2000 to 4000 platelets
What is the average total turnover rate of platelets in the body per day?
8 to 9 days
Which hormone or cytokine has shown synergistic interaction with thrombopoietin (TPO) and IL-3?
IL-6
What is the role of marrow macrophages in relation to thrombopoiesis?
They aid in platelet shedding
Which cytokine is NOT listed as having a synergistic interaction with TPO and IL-3 in platelet production?
EPO
What is the approximate number of megakaryocytes involved in producing platelets per day?
$10^8$
Test your knowledge on substances that inhibit megakaryocyte production and cytokines/hormones involved in platelet production. Explore how platelets are differentiated from progenitors, megakaryocytes, and their late maturation process. Understand the clinical use of thrombopoiesis factors.
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