Platelet Production Inhibitors and Cytokines/Hormones Involved in Platelet Production Quiz

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Questions and Answers

What is the average diameter of platelets?

  • 4.5 um
  • 3.5 um
  • 2.5 um (correct)
  • 1.5 um

How do circulating, resting platelets behave upon exposure to EDTA?

  • Remain unchanged
  • Shrink in size
  • Expand in size
  • Round up (correct)

Where do platelets cluster with erythrocytes in the blood vessel?

  • Near the endothelium
  • In the vein
  • Near the center (correct)
  • At the periphery

How do platelets appear on a Wright-stained wedge preparation blood film?

<p>Circular and lavender (A)</p> Signup and view all the answers

What is the normal platelet count in the peripheral blood?

<p>150 to 450 X 10^9/L (B)</p> Signup and view all the answers

What happens to sequestered platelets in times of demand?

<p>They are released into circulation (B)</p> Signup and view all the answers

What is the primary function of platelets when there is hemostatic need?

<p>Adhering to neighboring structures (A)</p> Signup and view all the answers

What distinguishes reticulated platelets from ordinary mature circulating platelets?

<p>They have a larger mean platelet volume (MPV) (B)</p> Signup and view all the answers

What is the diameter of reticulated platelets in peripheral blood films?

<p>6 um or greater (A)</p> Signup and view all the answers

How do reticulated platelets appear in EDTA?

<p>Round up (D)</p> Signup and view all the answers

Under steady-state conditions, what is the rate of platelet release from megakaryocytes equal to?

<p>Rate of platelet removal from circulation (C)</p> Signup and view all the answers

What is the estimated platelet turnover rate under healthy steady-state conditions?

<p>~35,000 platelets/mL/day (C)</p> Signup and view all the answers

How many platelets can a single megakaryocyte shed during the process known as thrombopoiesis?

<p>2000 to 4000 platelets (D)</p> Signup and view all the answers

What is the average total turnover rate of platelets in the body per day?

<p>8 to 9 days (B)</p> Signup and view all the answers

Which hormone or cytokine has shown synergistic interaction with thrombopoietin (TPO) and IL-3?

<p>IL-6 (C)</p> Signup and view all the answers

What is the role of marrow macrophages in relation to thrombopoiesis?

<p>They aid in platelet shedding (B)</p> Signup and view all the answers

Which cytokine is NOT listed as having a synergistic interaction with TPO and IL-3 in platelet production?

<p>EPO (C)</p> Signup and view all the answers

What is the approximate number of megakaryocytes involved in producing platelets per day?

<p>$10^8$ (D)</p> Signup and view all the answers

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