52 Questions
What is the role of ADP in platelet function?
Inducing platelet adherence and degranulation
Which molecule is responsible for mediating platelet constriction?
Serotonin
What is the primary function of Thromboxane A2 in platelet aggregation?
Stimulating platelet adherence
How do Prostacyclin I2 and Nitric Oxide contribute to hemostasis?
Inhibit platelet aggregation
What is the main role of Thrombin in the clotting pathway?
Converting fibrinogen to fibrin at the site of injury
Which molecule strengthens the plug formed by aggregated platelets?
Serotonin
What is the primary role of platelets in the process of hemostasis?
Forming a platelet plug
Which glycoprotein is responsible for linking platelets together to form platelet plugs?
GPIIb-IIIa
During which stage of hemostasis does the activation of coagulation factors lead to the production of thrombin?
Secondary hemostasis
What is the function of thromboxane A2 (TxA2) in the context of platelet activity?
Potent vasoconstrictor
Which component is responsible for attaching activated platelets to von Willebrand Factor (vWF)?
GPIb
In the context of hemostasis, where does fibrinolysis occur?
After the clot is no longer needed
What is the primary function of nitric oxide in hemostasis?
Inhibits platelet adhesion, aggregation, and binding of fibrinogen
Which molecule is a powerful vasodilator and interferes with platelet formation and aggregation?
Prostacyclin
During primary hemostasis, what is the main function of vonWillebrand Factor (vWF)?
Attracts other platelets to the site of injury
What initiates the vascular spasm during the hemostasis process?
TxA2 and ADP expression
How do platelets adhere to exposed collagen during hemostasis?
Utilizing vWF at specific receptors
What is the main outcome of the secondary hemostasis process?
Activation of clotting factors for coagulation
In the intrinsic pathway, which factor is involved in converting prothrombin to thrombin?
Factor Xa
What is the primary activator of prothrombin in the final common pathway of coagulation?
Factor Xa
Which activated factor contributes to the activation of Factors XIa and VIIIa in the intrinsic pathway?
Factor XIIa
In the coagulation cascade, what is the role of Factor VIII?
Activates Factor IX to IXa
Which factor is crucial for converting prothrombin to thrombin in the final common pathway?
Factor X
In the prothrombinase complex, what is the role of factor Va?
Increases the activity of factor Xa
Which factor is involved in the activation of factor IX to factor IXa in the extrinsic pathway?
Factor VIIa
How does vitamin K impact the production of prothrombin and other clotting factors by the liver?
Is required for normal synthesis of clotting factors by the liver
Which pathway is specific for coagulation initiation outside the intravascular space and is measured by PT and INR tests?
Extrinsic Pathway
What is the function of Thrombin in the final common pathway of coagulation?
Converts fibrinogen to fibrin
What is the function of prothrombinase in the clotting pathway?
Converts prothrombin to thrombin
Which coagulation factor is involved in both the intrinsic and extrinsic pathways of the clotting cascade?
Factor VII
In the final common pathway of the clotting cascade, what is the primary function of fibrin?
Forms a mesh to stabilize the clot
Which of the following accurately describes the extrinsic pathway of the clotting cascade?
Initiated by damage to blood vessel walls
What role do coagulation factors play in the intrinsic pathway of the clotting cascade?
Form prothrombinase complex
What is the significance of the final common pathway in the clotting cascade?
It produces fibrin from fibrinogen
Factor XII is the first plasma protein activated in the intrinsic pathway of the clotting cascade.
True
Thrombin plays a role in the activation of Factors XIa and VIIIa in the intrinsic pathway of the clotting cascade.
True
The final common pathway of the clotting cascade involves the conversion of prothrombin to thrombin by Xa and Va.
True
In the extrinsic pathway, Factor IX is activated to IXa by Factor XIa.
False
Prothrombinase complex consists of Xa, Va, and activated platelets in the final common pathway of coagulation.
True
The intrinsic pathway of the clotting cascade is initiated by blood trauma and exposure to collagen.
True
Thrombin generated from the extrinsic pathway is sufficient to provide adequate, sustained coagulation.
False
The final common pathway of the clotting cascade involves only the intrinsic pathway.
False
Prothrombinase is responsible for converting fibrinogen to fibrin in the clotting pathway.
False
The extrinsic pathway of the clotting cascade is activated when coagulation is initiated inside the intravascular space.
False
In the intrinsic pathway of the clotting cascade, everything necessary for clotting is found outside the blood.
False
Thrombin plays a significant role in activating platelets and clotting factors in the positive feedback loop of the clotting cascade.
True
In the final common pathway of the clotting cascade, the extrinsic and intrinsic pathways merge at factor Xa to produce thrombin.
True
Factor III, also known as Tissue Factor (TF), is a plasma protein involved in the intrinsic pathway.
False
Factor VIIa forms a complex with TF (Factor III) in the extrinsic pathway to activate factor X to Xa.
True
In the prothrombinase complex, factor Va and activated platelets help convert factor IX to IXa in the intrinsic pathway.
False
The extrinsic pathway is faster than the intrinsic pathway and is measured by PT and INR tests.
True
The liver requires vitamin K for the normal production of prothrombin and other clotting factors in both the extrinsic and intrinsic pathways.
False
Learn about the process of platelet plug formation and aggregation, including the activation triggers, release of mediators, and platelet aggregation onto the growing plug. Understand how platelets anchor to the subendothelium and induce changes in metabolism, shape, and surface.
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