14 Questions
What are the beneficial effects of acute inflammation?
Elimination of injurious stimulus
Which mediator is responsible for vasodilation?
Histamine
What can chronic inflammation lead to?
Resolution or scarring
What are the harmful effects of acute inflammation?
Digestion of normal tissues
Which factor is activated at the site of injury and helps in the formation of bradykinin?
Hageman Factor (XII)
Which enzyme converts prekallikrein to kallikrein in the kinin system?
XIIa
Which factor cleaves fibrinogen to form insoluble fibrin clot in the clotting system?
Thrombin
Which receptor does thrombin bind to, leading to P-selectin mobilization and expression of integrin ligands?
Protease-Activated Receptors (PARs)
What is the role of the fibrinolytic system?
Preventing uncontrolled fibrin production
How many pathways can activate the complement system?
Three
What is opsonization in the context of the inflammatory response?
Attachment of C3b to a microbe to enhance phagocytosis
Which components' deficiencies can lead to susceptibility to various infections and conditions?
C3, C2, C4, or late components
What are the outcomes of acute inflammation?
Resolution and organization
What does acute inflammation involve?
Dilation of blood vessels and leukocyte accumulation in the tissues
Study Notes
Inflammatory Response and Complement System Summary
- Fibrinolytic system prevents uncontrolled fibrin production, which can cause blood vessel blockage
- The complement system comprises proteins that play a role in host defense against microbes and in inflammatory reactions
- The complement system can be activated via three pathways: classic, alternative, and lectin
- Activation of the complement system leads to increased vascular permeability, chemotaxis, and opsonization
- Opsonization involves the attachment of C3b to a microbe, which enhances phagocytosis by macrophages
- Defects in the complement system, such as deficiencies in C3, C2, C4, or late components, can lead to susceptibility to various infections and conditions
- Acute inflammation is characterized by dilation of blood vessels and leukocyte accumulation in the tissues
- Different types of fluid accumulation in acute inflammation include catarrhal, serous, fibrinous, suppurative, and ulcers
- Acute inflammation outcomes can include resolution, where the tissue regenerates, or organization, leading to fibrosis or scarring
- The morphologic appearance of acute inflammation provides clues about its severity, cause, and tissue involvement
- Fibrinolysis and opsonization are processes involved in the inflammatory response and defense against microbes
- The complement system plays a crucial role in both innate and adaptive immunity, and its activation leads to various inflammatory responses and host defense mechanisms
Test your knowledge about the plasma-derived systems involved in inflammation, including the kinin system and the activation of Hageman factor (XII) at the site of injury. Learn about the formation of factor XIIa and the roles of kallikrein and bradykinin in the inflammatory response.
Make Your Own Quizzes and Flashcards
Convert your notes into interactive study material.
Get started for free
