Plasma-Derived Systems in Inflammation

What are the beneficial effects of acute inflammation?

Which mediator is responsible for vasodilation?

What can chronic inflammation lead to?

What are the harmful effects of acute inflammation?

Which factor is activated at the site of injury and helps in the formation of bradykinin?

Which enzyme converts prekallikrein to kallikrein in the kinin system?

Which factor cleaves fibrinogen to form insoluble fibrin clot in the clotting system?

Which receptor does thrombin bind to, leading to P-selectin mobilization and expression of integrin ligands?

What is the role of the fibrinolytic system?

How many pathways can activate the complement system?

What is opsonization in the context of the inflammatory response?

Which components' deficiencies can lead to susceptibility to various infections and conditions?

What are the outcomes of acute inflammation?

What does acute inflammation involve?

Inflammatory Response and Complement System Summary

Fibrinolytic system prevents uncontrolled fibrin production, which can cause blood vessel blockage
The complement system comprises proteins that play a role in host defense against microbes and in inflammatory reactions
The complement system can be activated via three pathways: classic, alternative, and lectin
Activation of the complement system leads to increased vascular permeability, chemotaxis, and opsonization
Opsonization involves the attachment of C3b to a microbe, which enhances phagocytosis by macrophages
Defects in the complement system, such as deficiencies in C3, C2, C4, or late components, can lead to susceptibility to various infections and conditions
Acute inflammation is characterized by dilation of blood vessels and leukocyte accumulation in the tissues
Different types of fluid accumulation in acute inflammation include catarrhal, serous, fibrinous, suppurative, and ulcers
Acute inflammation outcomes can include resolution, where the tissue regenerates, or organization, leading to fibrosis or scarring
The morphologic appearance of acute inflammation provides clues about its severity, cause, and tissue involvement
Fibrinolysis and opsonization are processes involved in the inflammatory response and defense against microbes
The complement system plays a crucial role in both innate and adaptive immunity, and its activation leads to various inflammatory responses and host defense mechanisms

Test your knowledge about the plasma-derived systems involved in inflammation, including the kinin system and the activation of Hageman factor (XII) at the site of injury. Learn about the formation of factor XIIa and the roles of kallikrein and bradykinin in the inflammatory response.