PKA and F-2

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Questions and Answers

What is the enzyme that converts PF-KINASE-2 into F-2,6-BISPHOSPHATASE?

  • Insulin
  • Protein kinase A (correct)
  • Adenylyl cyclase
  • Glucagon

What happens to glucagon secretion when blood glucose levels drop?

  • It remains unchanged
  • It increases (correct)
  • It falls
  • It becomes erratic

What happens when glucagon binds receptors on liver cells?

  • It activates adenylyl cyclase (correct)
  • It inhibits PKA
  • It activates insulin production
  • It hydrolyzes F-2,6-BP

What is the role of cAMP in the regulation of PKA?

<p>It binds to the regulatory subunits of PKA (B)</p> Signup and view all the answers

What happens to the bifunctional PFK-2/F-2,6-BPase when it is phosphorylated by PKA?

<p>It acts as a phosphatase (C)</p> Signup and view all the answers

What happens to the liver when it stops consuming glucose?

<p>It becomes gluconeogenic (A)</p> Signup and view all the answers

What happens to pancreatic insulin production when blood glucose levels drop?

<p>It falls (B)</p> Signup and view all the answers

What is the effect of glucagon on liver cells?

<p>It activates gluconeogenesis (D)</p> Signup and view all the answers

What is the role of PKA in the interconversion of PF-KINASE-2 and F-2,6-BISPHOSPHATASE?

<p>It phosphorylates PF-KINASE-2 (D)</p> Signup and view all the answers

What is the effect of circulating glucagon on blood glucose levels?

<p>It increases blood glucose levels (B)</p> Signup and view all the answers

What is the effect of phosphorylation on the activity of the bifunctional PFK-2/F-2,6-BPase?

<p>It activates its phosphatase activity (B)</p> Signup and view all the answers

What is the effect of falling blood glucose levels on insulin production?

<p>It decreases insulin production (A)</p> Signup and view all the answers

What is the enzyme that converts PF-KINASE-2 into F-2,6-BISPHOSPHATASE?

<p>Protein kinase A (C)</p> Signup and view all the answers

What happens to glucagon secretion when blood glucose levels drop?

<p>It increases (B)</p> Signup and view all the answers

What happens when glucagon binds receptors on liver cells?

<p>It activates adenylyl cyclase (A)</p> Signup and view all the answers

What is the role of cAMP in the regulation of PKA?

<p>It binds to the regulatory subunits of PKA (D)</p> Signup and view all the answers

What happens to the bifunctional PFK-2/F-2,6-BPase when it is phosphorylated by PKA?

<p>It acts as a phosphatase (A)</p> Signup and view all the answers

What happens to the liver when it stops consuming glucose?

<p>It becomes gluconeogenic (A)</p> Signup and view all the answers

What happens to pancreatic insulin production when blood glucose levels drop?

<p>It falls (C)</p> Signup and view all the answers

What is the effect of glucagon on liver cells?

<p>It activates gluconeogenesis (D)</p> Signup and view all the answers

What is the role of PKA in the interconversion of PF-KINASE-2 and F-2,6-BISPHOSPHATASE?

<p>It phosphorylates PF-KINASE-2 (A)</p> Signup and view all the answers

What is the effect of circulating glucagon on blood glucose levels?

<p>It increases blood glucose levels (B)</p> Signup and view all the answers

What is the effect of phosphorylation on the activity of the bifunctional PFK-2/F-2,6-BPase?

<p>It activates its phosphatase activity (D)</p> Signup and view all the answers

What is the effect of falling blood glucose levels on insulin production?

<p>It decreases insulin production (D)</p> Signup and view all the answers

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