Physiology Quiz: Action Potentials & Muscle Contraction
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Questions and Answers

Which of the following ions is responsible for phase 1 of the action potential of working ventricular cardiomyocytes?

  • Increased chloride conductance (gCl)
  • Increased calcium conductance (gCa)
  • Increased sodium conductance (gNA) (correct)
  • Increased potassium conductance (gK)

Which of the following ions is responsible for phase 1 of the action potential of conduction ventricular cardiomyocytes?

  • Increased potassium conductance (gK)
  • Increased calcium conductance (gCa) (correct)
  • Increased sodium conductance (gNA)
  • Increased chloride conductance (gCl)

In relation to muscle contraction, the sarcomere consists of thin filaments of actin and thick filaments of myosin.

True (A)

In relation to muscle contraction, the energy is used for the "rowing stroke" of the contraction.

<p>True (A)</p> Signup and view all the answers

In relation to muscle contraction, at rest, tropomyosin prevents actin-myosin binding.

<p>True (A)</p> Signup and view all the answers

In relation to muscle contraction, the actual length of actin and myosin filaments does not vary during contraction.

<p>False (B)</p> Signup and view all the answers

Which is the primary function of tropomyosin?

<p>To prevent the actin-myosin binding (A)</p> Signup and view all the answers

During muscle contraction, the energy obtained from the ATP hydrolysis is used to:

<p>Produce the &quot;rowing stroke&quot; of the myosin (C)</p> Signup and view all the answers

Which of the following circumstances leads to an INCREASE in cardiac output?

<p>Decreased afterload (B)</p> Signup and view all the answers

You receive a 5-year-old patient with bacterial meningitis in the Pediatric ICU. The patient suffers from septic shock, with a tendency to hypotension and tissue hypoperfusion. Which of the following measures seems LESS appropriate in this patient?

<p>To increase positive expiratory pressure on the ventilator to increase cardiac afterload (C)</p> Signup and view all the answers

All of the following lead to a preload increase, EXCEPT for:

<p>Valsalva maneuver (C)</p> Signup and view all the answers

In relation to the cardiac cycle, which of the following statements is TRUE?

<p>The closure of the aortic valve precedes the closure of the pulmonary valve (A)</p> Signup and view all the answers

The phase of the cardiac cycle indicated by number 1 represents

<p>Isovolumetric contraction (D)</p> Signup and view all the answers

The "auricular systole" is represented by number:

<p>6 (D)</p> Signup and view all the answers

The closure of the mitral valve takes place before the closure of the tricuspid valve.

<p>True (A)</p> Signup and view all the answers

The closure of the pulmonary valve is delayed during inspiration.

<p>True (A)</p> Signup and view all the answers

The closure of the aortic valve is delayed during inspiration.

<p>False (B)</p> Signup and view all the answers

Branch blocks can lead to a reverse splitting of heart sounds.

<p>True (A)</p> Signup and view all the answers

Angiotensin I is converted to angiotensin II by renin.

<p>False (B)</p> Signup and view all the answers

Angiotensin II induces aldosterone release.

<p>True (A)</p> Signup and view all the answers

PAN inhibits the release of renin.

<p>True (A)</p> Signup and view all the answers

Juxtaglomerular cells can detect a decrease in circulating volume, activating renin release.

<p>True (A)</p> Signup and view all the answers

The increase in discharge rate of aortic and carotid baroreceptors leads to:

<p>Decreased blood pressure (A)</p> Signup and view all the answers

In conduction cardiomyocytes, unlike working cardiomyocytes, phase 0 of the action potential depends mostly on:

<p>Increased calcium conductance (A)</p> Signup and view all the answers

All of the following situations ones can lead to a DECREASE in blood pressure, EXCEPT for:

<p>Increased venous return to the left heart. (B)</p> Signup and view all the answers

During a normal cardiac cycle, it is FALSE that the ventricular pressure is maximal during the ventricular ejection phase.

<p>False (B)</p> Signup and view all the answers

During a normal cardiac cycle, it is FALSE that the first cardiac sound corresponds to the closure of the atrioventricular valves.

<p>False (B)</p> Signup and view all the answers

During a normal cardiac cycle, it is FALSE that the rapid ventricular filling phase occurs at the beginning of diastole.

<p>False (B)</p> Signup and view all the answers

During a normal cardiac cycle, it is FALSE that during isovolumetric relaxation, the atrial pressure is greater than the ventricular pressure.

<p>True (A)</p> Signup and view all the answers

Which is the main responsible for airway resistance (or non - elastic resistance) during breathing?

<p>The upper airway (D)</p> Signup and view all the answers

In relation to the pulmonary elastic resistance, it is true that lungs with increased distensibility have trouble with air intake.

<p>False (B)</p> Signup and view all the answers

In relation to the pulmonary elastic resistance, it is true that lungs with decreased distensibility have trouble with expiration.

<p>True (A)</p> Signup and view all the answers

In relation to the pulmonary elastic resistance, it is true that total lung capacity is determined by lung distensibility.

<p>False (B)</p> Signup and view all the answers

In relation to the pulmonary elastic resistance, it is true that in a healthy adult, the residual volume after forced expiration is negligible.

<p>False (B)</p> Signup and view all the answers

A patient with increased lung distensibility probably presents

<p>A greater vital capacity (D)</p> Signup and view all the answers

The concept of " vital capacity " in a conventional spirometry refers to:

<p>The amount of air a person can expel after a maximum inspiration (C)</p> Signup and view all the answers

The definition "volume of air remaining in the lungs after a normal expiration (not forced)" refers to:

<p>The residual volume (C)</p> Signup and view all the answers

The attached image represents a static spirometry. The volume of air indicated by number 1 represents:

<p>The inspiratory capacity (A)</p> Signup and view all the answers

After performing a forced spirometry, one of the most important data in daily clinical practice is the Tiffeneau index. A Tiffeneau index below 70% shows:

<p>An air outtake disorder (obstructive pattern) (D)</p> Signup and view all the answers

Which is the MOST important inspiratory stimulus in people without underlying disorders?

<p>Increased partial pressure of carbon dioxide (C)</p> Signup and view all the answers

The measurement of the diffusing capacity for carbon monoxide (DLCO) enables the estimation of the functional status of the alveolar-capillary membrane. Which of the following agents leads to a decrease in DLCO, or in other words, to a decrease in the diffusion capacity of the alveolar-capillary membrane?

<p>Thicker alveolar-capillary membrane (D)</p> Signup and view all the answers

The pulmonary circulation presents a series of special characteristics that differentiate it from the systemic circulation. Which of the following is NOT a characteristic of the pulmonary circulation?

<p>Tendency to hypoxic vasodilation, unlike the systemic circulation (B)</p> Signup and view all the answers

The oxygen-hemoglobin dissociation curve presents a sigmoidal shape. This enables that small variations in the partial pressure of oxygen in the middle part of the curve entail large changes in the oxygen saturation. On the other hand, there are also some factors that modify the oxygen affinity of hemoglobin, or in other words, that "shift the curve to the right" (lower affinity), or "shift the curve to the left" (higher affinity). Which of the following factors does not shift the dissociation curve to the right?

<p>True (A)</p> Signup and view all the answers

Which of the following properties is NOT typical of adaptive immunity?

<p>To recognize highly conserved microbial structures shared by different types of microbial species (B)</p> Signup and view all the answers

Which of the following elements is NOT part of adaptive immunity?

<p>Lactoferrin (C)</p> Signup and view all the answers

Flashcards

What ion is responsible for phase 1 of the action potential in working ventricular cardiomyocytes?

The initial rapid depolarization phase of an action potential in working ventricular cardiomyocytes is primarily driven by the influx of sodium ions.

What ion is responsible for phase 1 of the action potential in conduction ventricular cardiomyocytes?

Phase 1 of the action potential in conduction ventricular cardiomyocytes is characterized by a rapid depolarization driven by the influx of calcium ions.

What ion is responsible for phase 2 of the action potential in working ventricular cardiomyocytes?

Phase 2 of the action potential in working ventricular cardiomyocytes, also known as the plateau phase, is maintained by the slow influx of calcium ions.

What ion is responsible for phase 3 of the action potential in working ventricular cardiomyocytes?

Phase 3 of the action potential in working ventricular cardiomyocytes, the repolarization phase, is primarily driven by the efflux of potassium ions.

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What are the components of a sarcomere?

The sarcomere, the basic functional unit of a muscle fiber, is composed of thin filaments (actin) and thick filaments (myosin).

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What is the primary function of tropomyosin?

Tropomyosin functions as a blocking protein that prevents the interaction between actin and myosin in a relaxed muscle.

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What is the role of ATP hydrolysis in muscle contraction?

During muscle contraction, the energy from ATP hydrolysis is used to detach the myosin head from actin, allowing the myosin to bind to a new actin binding site further along the filament.

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What circumstance leads to an increase in cardiac output?

Cardiac output, the volume of blood pumped by the heart per minute, increases when afterload is decreased.

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What circumstance leads to a decrease in cardiac output?

A decrease in preload, the amount of blood in the ventricle at the end of diastole, will actually decrease cardiac output.

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What measure is less appropriate for a patient with septic shock?

In a patient with septic shock, increasing cardiac afterload through positive expiratory pressure can worsen the condition.

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What action does NOT lead to an increase in preload?

The Valsalva maneuver, a forced exhalation against a closed glottis, decreases preload by compressing the veins and reducing venous return.

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What is TRUE about atrial systole in the cardiac cycle?

Atrial systole contributes a significant portion of the ventricular end-diastolic volume (amount of blood in the ventricle at the end of diastole). It's not 50%, but it's still important though.

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What phase of the cardiac cycle is represented by number 1?

During isovolumetric contraction, the ventricles are contracting but all valves are closed, so the volume of blood in the ventricle remains constant, and the ventricular pressure rises.

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What phase of the cardiac cycle is represented by number 3?

Isovolumetric relaxation occurs immediately after the closure of the aortic and pulmonary valves, when the ventricles are relaxing and all valves are closed, and the ventricular pressure drops.

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What number represents auricular systole?

The auricular systole, or atrial contraction, is the final phase of the cardiac cycle, preceding the diastole.

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What statement about the cardiac cycle is FALSE?

The closure of the aortic valve is NOT delayed during inspiration. It's the pulmonary valve closure that is.

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What is the FALSE statement about the RAAS?

Angiotensin I is converted to angiotensin II by the enzyme angiotensin-converting enzyme (ACE), not by renin.

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What is the effect of increased discharge of the baroreceptors?

Increased discharge of aortic and carotid baroreceptors leads to a decrease in blood pressure.

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What is the main factor in phase 0 of the action potential in conduction cardiomyocytes?

In conduction cardiomyocytes, phase 0 of the action potential is primarily driven by the influx of calcium ions, not sodium ions, due to the presence of L-type calcium channels.

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What does NOT lead to a decrease in blood pressure?

Increased venous return to the left heart will actually increase blood pressure due to increased preload and cardiac output.

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What is FALSE about a normal cardiac cycle?

During the rapid ventricular filling phase, the atria are relaxed and the ventricles are filling with blood, with the pressure in the ventricle being lower than in atrium.

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What is the main factor in airway resistance?

In the normal airway, the small caliber airways (terminal and respiratory bronchioles) contribute the most to airway resistance.

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Study Notes

Physiology Questions

  • Question 1: Phase 1 of the action potential in working ventricular cardiomyocytes is caused by increased sodium conductance (gNA).
  • Question 2: Phase 1 of the action potential in conduction ventricular cardiomyocytes is caused by increased calcium conductance (gCa).
  • Question 3: Phase 2 of the action potential in working ventricular cardiomyocytes is caused by increased calcium conductance (gCa).
  • Question 4: Phase 3 of the action potential in working ventricular cardiomyocytes is caused by increased potassium conductance (gK).
  • Question 5: The statement that is FALSE regarding muscle contraction is the following: The actual length of actin and myosin filaments does not vary during contraction.

Muscle Contraction

  • Sarcomere Structure: The sarcomere consists of thin actin filaments and thick myosin filaments.
  • Energy Source: Energy used for muscle contraction comes from ATP hydrolysis during the "rowing stroke"
  • Tropomyosin Function: Tropomyosin prevents actin-myosin binding at rest.

Cardiac Output and Circumstances

  • Increase in Cardiac Output: Decreased afterload increases cardiac output.
  • Decrease in Cardiac Output: Increased afterload decreases cardiac output.

Cardiac Cycle and Valves

  • Cardiac Cycle Phases: Isovolumetric contraction is one of the heart phases.
  • Valve Closure: Closure of the aortic valve precedes closure of the pulmonary valve during the cardiac cycle.
  • Atrial Contraction and Preload: Atrial contraction, increased venous tone, and expansion of circulating volume all increase preload, except for the Valsalva maneuver.

Bacterial Meningitis & Hypotension

  • Less Appropriate Measure: Giving saline to increase blood volume to increase blood pressure.

Other Facts

  • Renin-Angiotensin-Aldosterone System (RAAS): ANGIOTENSIN II induces Aldosterone release, but PAN (a substance) does not inhibit renin release. 
  • Aortic/Carotid Baroreceptors: Increasing discharge rate leads to decreased blood pressure, not an increase.
  • Cardiac Action Potentials (working cardiomyocytes): In Phase 0 of the action potential, increased sodium conductance through rapid channels is the primary contributor.

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Description

Test your knowledge on the phases of action potentials and the mechanics of muscle contraction. This quiz covers important concepts related to cardiac physiology and the structural components of sarcomeres. Dive into the details of sodium, calcium, and potassium conductance as well as the energy sources for muscle movement.

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