Physiology of Pulmonary and Autonomic Systems
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Questions and Answers

What is the primary effect of pulmonary hypoxia on the pulmonary blood vessels?

  • Produces vasoconstriction (correct)
  • Reduces blood pressure
  • Increases blood flow
  • Enhances vasodilation
  • How does the sympathetic nervous system primarily cause vasoconstriction?

  • By binding noradrenaline to beta-adrenoreceptors
  • By decreasing intracellular calcium levels
  • By binding noradrenaline to alpha-adrenoreceptors (correct)
  • By increasing nitric oxide production
  • What is the role of the baroreceptor reflex in maintaining blood pressure?

  • Inhibits blood vessel stretch receptors
  • Stimulates adrenaline release
  • Decreases heart rate to lower blood pressure (correct)
  • Increases heart rate to raise blood pressure
  • Where are arterial chemoreceptors primarily located?

    <p>In the aortic arch and carotid arteries (D)</p> Signup and view all the answers

    What type of capillaries allows for the passage of blood cells due to large gaps?

    <p>Discontinuous capillaries (B)</p> Signup and view all the answers

    Which mechanism involves sensors detecting changes to maintain homeostasis?

    <p>Sensory input (B)</p> Signup and view all the answers

    What role do veno-atrial receptors play in the cardiovascular system?

    <p>Monitor blood volume (A)</p> Signup and view all the answers

    What is the mechanism through which water passes across the capillary wall?

    <p>Through protein channels called aquaporins (D)</p> Signup and view all the answers

    What response occurs due to low oxygen levels in the environment at high altitudes?

    <p>Pulmonary vasoconstriction leading to pulmonary hypertension (A)</p> Signup and view all the answers

    What is the primary effect of adrenaline binding to beta-adrenoreceptors in the vascular system?

    <p>Relaxation of smooth muscle and vasodilation (A)</p> Signup and view all the answers

    What physiological changes occur in anticipation of exercise?

    <p>Increased heart rate and increased breathing rate (C)</p> Signup and view all the answers

    What is the role of arterio-venous anastomoses in acral skin?

    <p>To regulate skin blood flow for thermoregulation (B)</p> Signup and view all the answers

    Which area of the body contains acral skin?

    <p>Fingers and toes (B)</p> Signup and view all the answers

    How does the cerebral cortex influence autonomic responses during exercise?

    <p>By regulating heart rate and respiratory neurons (B)</p> Signup and view all the answers

    What mechanism contributes to heat loss in acral areas of the body?

    <p>Dilation of arterio-venous anastomoses to increase skin blood flow (C)</p> Signup and view all the answers

    What causes edema in the interstitium?

    <p>Fluid produced in capillaries exceeds fluid removed (A)</p> Signup and view all the answers

    Which forces contribute to the movement of water across capillary walls?

    <p>Capillary hydrostatic pressure and osmotic pressure (B), Colloid osmotic pressure of plasma and interstitial pressure (C)</p> Signup and view all the answers

    What relationship does Fick's Law of Diffusion describe?

    <p>Rate of diffusion is proportional to the concentration gradient (D)</p> Signup and view all the answers

    During dynamic exercise, what happens to systolic blood pressure?

    <p>It increases due to alternating muscle contractions (B)</p> Signup and view all the answers

    What happens to venous blood distribution when standing up from a supine position?

    <p>Venous blood pools in the legs (A)</p> Signup and view all the answers

    Which factor affects arterial pressure throughout the day?

    <p>Circadian rhythms and activity changes (A)</p> Signup and view all the answers

    What occurs to blood flow during static exercise, such as a prolonged handgrip?

    <p>Muscle compression leads to peripheral vasoconstriction and impaired blood flow (D)</p> Signup and view all the answers

    What is the primary function of the lymphatic system in relation to fluid balance?

    <p>To drain excess fluid back to the venous system (D)</p> Signup and view all the answers

    Which factor directly increases the flow rate in a blood vessel according to Darcy's Law?

    <p>Increase in pressure difference (A)</p> Signup and view all the answers

    What is the primary effect of vasodilation on a blood vessel?

    <p>Increase in vessel compliance (A)</p> Signup and view all the answers

    What happens during the myogenic response when arterial pressure initially increases?

    <p>Vessel radius decreases (A)</p> Signup and view all the answers

    What primarily characterizes the compliance of blood vessels?

    <p>Degree of stretch in response to pressure (D)</p> Signup and view all the answers

    What mechanism is primarily involved in the active hyperemia response?

    <p>Metabolite-induced vasodilation (A)</p> Signup and view all the answers

    Which statement accurately describes post-exercise hyperemia?

    <p>Increases in blood flow velocity follow relaxation of muscle (A)</p> Signup and view all the answers

    What is the role of calcium ions ($Ca^{2+}$) in the myogenic response?

    <p>They activate voltage-gated channels regulating vessel contraction (A)</p> Signup and view all the answers

    What primarily differentiates intrinsic and extrinsic blood flow control mechanisms?

    <p>Intrinsic is local; extrinsic involves neurohormonal systems (C)</p> Signup and view all the answers

    What triggers the contraction of heart muscle cells during the plateau phase of the ventricular action potential?

    <p>Influx of Ca2+ ions (A)</p> Signup and view all the answers

    Which phase of the cardiac cycle corresponds to the isovolumetric contraction of the ventricles?

    <p>Phase II (C)</p> Signup and view all the answers

    What is represented by the QRS interval in an ECG?

    <p>Ventricular depolarization (D)</p> Signup and view all the answers

    Which of the following best describes the function of the SA node in the cardiac conduction system?

    <p>Transmits electrical impulses to the atria (D)</p> Signup and view all the answers

    What occurs during Phase 4 of the ventricular action potential?

    <p>Resting membrane potential is reached (C)</p> Signup and view all the answers

    During which phase of the cardiac cycle does the aortic valve close?

    <p>Isovolumetric relaxation phase (C)</p> Signup and view all the answers

    What is the significance of the refractory period established during the plateau phase?

    <p>Prevents continuous contraction or tetanus (A)</p> Signup and view all the answers

    What does the PR interval in an ECG represent?

    <p>Delay at the AV node during atrial depolarization (B)</p> Signup and view all the answers

    During which phase of the cardiac cycle does the mitral valve open, leading to passive filling of the ventricles?

    <p>Isovolumetric relaxation (A)</p> Signup and view all the answers

    What characterizes the compliance of large elastic arteries such as the aorta?

    <p>Thick walls with lots of elastin (D)</p> Signup and view all the answers

    How does an increase in right atrial pressure affect the energy of cardiac muscle contraction following Starling's law?

    <p>Increases preload, enhancing contraction energy (A)</p> Signup and view all the answers

    Which type of blood vessel acts as the primary site for gas exchange due to its structure?

    <p>Capillaries (D)</p> Signup and view all the answers

    What occurs during the ejection phase of the cardiac cycle?

    <p>The aortic valve opens (A)</p> Signup and view all the answers

    What is the primary function of the sinoatrial node in the human heart?

    <p>To act as a physiological pacemaker (D)</p> Signup and view all the answers

    Which of the following describes the correct relationship of cardiac output?

    <p>CO = SV × HR (D)</p> Signup and view all the answers

    What occurs during diastole in the cardiac cycle?

    <p>The heart relaxes to allow ventricular filling (B)</p> Signup and view all the answers

    Which of the following best defines end diastolic volume (EDV)?

    <p>The largest volume of blood in the ventricles (D)</p> Signup and view all the answers

    What effect does an increase in sympathetic activity have on heart rate?

    <p>It increases heart rate (A)</p> Signup and view all the answers

    Flashcards

    Pulmonary Hypoxia

    Low oxygen levels in the lungs, causing vasoconstriction of pulmonary blood vessels.

    Ventilation Perfusion Matching

    Balancing air flow (ventilation) with blood flow (perfusion) in the lungs.

    Sympathetic Nervous System Role in Blood Vessels

    Noradrenaline (released by the sympathetic nervous system) causes vasoconstriction by binding to alpha-adrenoreceptors on smooth muscle cells, leading to contraction.

    Parasympathetic Nervous System Role in Blood Vessels

    Adrenaline (released by the sympathetic nervous system) causes vasodilation by binding to beta-adrenoreceptors on smooth muscle cells, leading to relaxation.

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    Baroreceptor Reflex

    A feedback mechanism that regulates blood pressure. Baroreceptors detect changes in blood pressure and send signals to the medulla to adjust heart rate.

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    Veno-atrial Receptors

    Located in veins, they monitor blood volume and pressure.

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    Arterial Chemoreceptors

    Sensors in arteries responsible for detecting changes in blood oxygen, carbon dioxide, and pH.

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    Continuous Capillaries

    The most common type of capillary, with a continuous wall of endothelial cells with no gaps, allowing the passage of small molecules but not blood cells.

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    Fenestrated Capillaries

    Capillaries with pores in the endothelial cells, allowing for the filtration of blood and other fluids like urine.

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    Discontinuous Capillaries

    Capillaries with large gaps between endothelial cells, allowing the passage of both fluids and large molecules, including blood cells.

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    Central Command Hypothesis

    The idea that the brain anticipates exercise and sends signals to increase heart rate and breathing rate before physical activity begins.

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    Autonomic Nervous System Role

    The autonomic nervous system, controlled by the brain, influences the heart and respiratory system to prepare for exercise.

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    Acral Skin

    Skin on the fingers, toes, palms, and soles, involved in thermoregulation and heat loss.

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    Arterio-venous Anastomoses

    Special blood vessels in acral skin that dilate to increase blood flow and promote heat loss.

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    Thermoregulation of Acral Skin

    Acral skin, due to its arterio-venous anastomoses, plays a crucial role in regulating body temperature by increasing blood flow to the surface to promote heat loss.

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    Fick's Law of Diffusion

    Describes how substances move across membranes based on concentration differences, surface area, and membrane thickness.

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    Metabolic Flux

    The rate at which substances move across a capillary wall.

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    Starling Forces

    Pressure differences that drive fluid movement across capillary walls.

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    What are the forces pulling fluid out of the capillary?

    Capillary pressure and interstitial pressure.

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    What forces pull fluid into the capillary?

    Colloid osmotic pressure of plasma.

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    Edema

    Excess fluid in the interstitium, causing swelling.

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    Orthostatic Response

    How the body reacts to postural changes.

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    Baroreceptor Reflex During Exercise

    The mechanism that keeps blood pressure stable during exercise.

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    Darcy's Law

    Describes the relationship between pressure difference, vessel radius, length, and fluid viscosity, determining the flow rate of blood.

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    Vasodilation

    An increase in the diameter of a blood vessel, leading to increased blood flow.

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    Vasoconstriction

    A decrease in the diameter of a blood vessel, reducing blood flow.

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    Myogenic Response

    Blood vessels automatically constrict in response to increased pressure, helping to regulate blood flow.

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    Compliance

    A blood vessel's ability to stretch in response to pressure change.

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    Capacitance

    The ability of a blood vessel, especially veins, to hold a large volume of blood.

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    Active Hyperemia

    Increased blood flow to active tissues, driven by local metabolites.

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    Post-exercise Hyperemia

    Sustained blood flow increase to muscles after exercise, due to lingering metabolites.

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    SA Node

    The sinoatrial node (SA node) is the pacemaker of the heart. It initiates the electrical impulses that trigger heart contractions.

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    AV Node

    The atrioventricular node (AV node) delays the electrical impulse briefly, allowing the atria to contract before the ventricles.

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    Bundle of His

    The bundle of His transmits the electrical impulse from the AV node to the ventricles.

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    What is Phase 0 of a ventricular action potential?

    Phase 0 is the rapid depolarization phase. This occurs when voltage-gated sodium channels open, allowing sodium ions to rush into the cell, causing a sudden increase in membrane potential.

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    What is the Plateau Phase?

    The plateau phase (Phase 2) is characterized by a prolonged period where the membrane potential remains relatively stable. This is due to the slow influx of calcium ions and a decreased potassium permeability.

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    What is the Importance of the Plateau Phase?

    The plateau phase is essential for cardiac muscle contraction. It allows for a prolonged influx of calcium ions, which triggers the release of more calcium from the sarcoplasmic reticulum, initiating contraction.

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    P Wave on ECG

    The P wave represents atrial depolarization, the electrical activity that spreads through the atria before contraction.

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    QRS Complex on ECG

    The QRS complex represents ventricular depolarization, the electrical activity that triggers the ventricles to contract.

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    Aortic valve closes

    This marks the end of the ejection phase and the beginning of isovolumetric relaxation. Ventricular pressure becomes lower than aortic pressure.

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    Mitral valve opens

    Ventricular pressure drops below atrial pressure, allowing blood to passively flow into the ventricle during diastole.

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    Starling Law

    The force of contraction of a cardiac muscle fiber is proportional to the initial resting length. Greater preload leads to greater energy of contraction.

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    What are resistance vessels?

    Arterioles are described as resistance vessels because they have a high resistance to blood flow due to their small diameter and thick smooth muscle layer.

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    Capacitance vessels

    Veins are capacitance vessels because they can hold a large volume of blood, acting as a reservoir before returning blood to the heart.

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    Cardiac Output

    The amount of blood pumped by the heart per minute. It's calculated by multiplying stroke volume (SV) by heart rate (HR).

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    What is Diastole?

    The relaxation phase of the heart cycle, when the ventricles fill with blood.

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    What is Systole?

    The contraction phase of the heart cycle, when the ventricles pump blood out.

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    ESV

    End Systolic Volume. The minimum volume of blood remaining in the ventricle after contraction (systole).

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    Study Notes

    Pulmonary Hypoxia (Low O₂)

    • Causes vasoconstriction of pulmonary blood vessels
    • Matching of air and blood flow is coordinated
    • High altitudes lead to low oxygen in the air, causing short-term pulmonary vasoconstriction, directing blood to areas with higher oxygen levels and resulting in pulmonary hypertension.
    • Process of coordinating the flow of air into the lungs with the flow of blood into the lungs.

    Autonomic Regulation of Cardiovascular System

    • Sympathetic Nervous System (L-Sympathetic): Causes vasoconstriction by norepinephrine

      • Norepinephrine binds to alpha-1 and alpha-2 adrenergic receptors on smooth muscle cells in blood vessels, increasing intracellular calcium which contracts smooth muscle.
      • The short term response to a change in blood flow is vasoconstriction.
    • Parasympathetic Nervous System (Vasodilation): Mediated by Beta-adrenergic receptors.

      • Adrenaline binds to beta-adrenergic receptors causing relaxation of vascular smooth muscles leading to vasodilation.

    Negative Feedback Control

    • Sensors detect changes
    • Signal is propagated to the processor unit
    • Effector mechanisms respond accordingly
    • Maintaining homeostasis

    Baroreceptor Reflex

    • Mechanoreceptors that detect changes in blood pressure
    • Located in the walls of the aortic arch and carotid arteries
    • Increase in pressure stretches the vessel wall, detected by baroreceptors, sending signals to the medulla; reduces heart rate for lower blood pressure to set point.
    • The signal is relayed to adjust/maintain blood pressure.

    Veno-Atrial Receptors

    • Detect changes in blood volume (low pressure)
    • Located at the junction between veins and atria (in pulmonary artery)
    • Helpful in cardiac-pulmonary responses
    • Monitor blood volume and respond to low pressure conditions in veins

    Arterial Chemoreceptors

    • Detect oxygen, carbon dioxide, and pH levels.
    • Responds to hypoxia (low oxygen) and hypercapnia (high carbon dioxide)
    • Sending signals to the brainstem to increase sympathetic activity
    • Detect changes in O2, CO2 and pH to the brainstem which relay into a sympathetic response

    Capillaries

    • Site for gas and metabolic exchange.
    • Made of small arterioles and capillaries where metabolites and respiratory gases pass across the capillary wall via diffusion.

    Continuous Capillary

    • Most common type
    • The entire capillary wall is composed of endothelial cells with no gaps.

    Fenestrated Capillary

    • Contains small gaps between endothelial cells.
    • Found in places requiring rapid filtration, absorption, or secretion. (e.g. small intestine, endocrine glands, and glomerulus of the kidneys)
    • Rapid filtration, absorption, or secretion

    Discontinuous Capillary

    • Have large gaps between endothelial cells.
    • Blood cells can pass through the wall. (e.g. liver, spleen, and bone marrow)
    • Blood cells and large proteins can pass through
    • Water passes through capillaries by aquaporins (water channels) or endothelial gaps.

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    Description

    This quiz covers key concepts in pulmonary hypoxia and the autonomic regulation of the cardiovascular system. It examines the physiological responses to low oxygen levels and the roles of the sympathetic and parasympathetic nervous systems in regulating blood flow. Test your understanding of these critical processes and their implications on human health.

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