10 Questions
What is the result of parabiosis between db/db and Wildtype mice?
Starvation in Wildtype, normal feeding in db/db
What is the effect of leptin mutations on the body?
Hyperphagia and obesity as the body does not know about its energy status
Where does leptin mediate its satiating effects?
Hypothalamus, specifically in the arcuate nucleus (ARC), ventromedial nucleus (VMN), and lateral hypothalamic area (LHA)
What is the function of NPY/agRP neurons in the arcuate nucleus?
Release Neuropeptide Y and Agouti-related peptide, stimulating appetite
How do orexins trigger appetite responses?
Through release from the lateral hypothalamic area, affecting organs such as the stomach, pancreas, and adipocytes
What is the role of leptin in hunger regulation?
Communicates body's energy state to the CNS to suppress food intake
What is produced by adipocytes in proportion to triglyceride content?
Leptin
What is the result of parabiosis between ob/ob and db/db mice?
Starvation in ob/ob, normal feeding in db/db
What is the effect of leptin on POMC neurons?
Stimulation, promoting feelings of satiety
How does leptin interact with ghrelin?
Leptin counteracts ghrelin's appetite-stimulating effects
This quiz covers the roles of leptin and ghrelin hormones in regulating energy metabolism, appetite, and body energy stores. It explores how adipocytes produce leptin and how ghrelin is secreted by the stomach in response to stomach content.
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