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Physiology of Leptin and Ghrelin Hormones

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Physiology of Leptin and Ghrelin Hormones

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Questions and Answers

What is the result of parabiosis between db/db and Wildtype mice?

Starvation in Wildtype, normal feeding in db/db

What is the effect of leptin mutations on the body?

Hyperphagia and obesity as the body does not know about its energy status

Where does leptin mediate its satiating effects?

Hypothalamus, specifically in the arcuate nucleus (ARC), ventromedial nucleus (VMN), and lateral hypothalamic area (LHA)

What is the function of NPY/agRP neurons in the arcuate nucleus?

Release Neuropeptide Y and Agouti-related peptide, stimulating appetite Signup and view all the answers

How do orexins trigger appetite responses?

Through release from the lateral hypothalamic area, affecting organs such as the stomach, pancreas, and adipocytes Signup and view all the answers

What is the role of leptin in hunger regulation?

Communicates body's energy state to the CNS to suppress food intake Signup and view all the answers

What is produced by adipocytes in proportion to triglyceride content?

Leptin Signup and view all the answers

What is the result of parabiosis between ob/ob and db/db mice?

Starvation in ob/ob, normal feeding in db/db Signup and view all the answers

What is the effect of leptin on POMC neurons?

Stimulation, promoting feelings of satiety Signup and view all the answers

How does leptin interact with ghrelin?

Leptin counteracts ghrelin's appetite-stimulating effects Signup and view all the answers