Podcast
Questions and Answers
What controls the degree of tone of the penile vasculature and the smooth muscle in the physiology of an erection?
What controls the degree of tone of the penile vasculature and the smooth muscle in the physiology of an erection?
The balance between contractant (flaccid) and relaxant (erection) factors
What is the physiological function of the corpora cavernosa in the context of an erection?
What is the physiological function of the corpora cavernosa in the context of an erection?
The cavernosal spaces make up the corpus cavernosum.
Name three neurotransmitters involved in penile vasculature and smooth muscle physiology related to erection.
Name three neurotransmitters involved in penile vasculature and smooth muscle physiology related to erection.
Acetylcholine (ACh), Noradrenaline, Dopamine (DA)
What are the two functional states of the penis determined by the balance of contractant and relaxant factors?
What are the two functional states of the penis determined by the balance of contractant and relaxant factors?
What role do cerebral sex centers play in the physiology of an erection?
What role do cerebral sex centers play in the physiology of an erection?
What is the role of cGMP-specific protein kinase (Protein Kinase G) in the process of achieving an erection?
What is the role of cGMP-specific protein kinase (Protein Kinase G) in the process of achieving an erection?
How does the inhibition of PDE-5 contribute to the mechanism of achieving an erection?
How does the inhibition of PDE-5 contribute to the mechanism of achieving an erection?
Explain the role of Potassium (K+) in the process of erection.
Explain the role of Potassium (K+) in the process of erection.
What is the significance of Phosphatase in the process of achieving an erection?
What is the significance of Phosphatase in the process of achieving an erection?
How do PDE5 inhibitors work to treat erectile dysfunction?
How do PDE5 inhibitors work to treat erectile dysfunction?
What is the main tissue localization of PDE (Phosphodiesterase) in the context of erection?
What is the main tissue localization of PDE (Phosphodiesterase) in the context of erection?
What is the role of Acetylcholine (ACh) in the penile vascular smooth muscle relaxation?
What is the role of Acetylcholine (ACh) in the penile vascular smooth muscle relaxation?
In the flaccid state, what is involved in smooth muscle contraction?
In the flaccid state, what is involved in smooth muscle contraction?
What is the main mechanism of penile vascular smooth relaxation during erection?
What is the main mechanism of penile vascular smooth relaxation during erection?
What is the more common name for the 'cGMP-specific kinase' depicted in green in the illustration?
What is the more common name for the 'cGMP-specific kinase' depicted in green in the illustration?
What is the role of Cialis in penile vascular smooth muscle relaxation?
What is the role of Cialis in penile vascular smooth muscle relaxation?
What is the washout time for Cialis?
What is the washout time for Cialis?
What is the role of Protein Kinase G in the vascular smooth muscle cell?
What is the role of Protein Kinase G in the vascular smooth muscle cell?
How does Protein Kinase G affect the potassium channels in the plasma membrane of vascular smooth muscle cells?
How does Protein Kinase G affect the potassium channels in the plasma membrane of vascular smooth muscle cells?
What is the 'Kick In' time for Tadalafil (Cialis)?
What is the 'Kick In' time for Tadalafil (Cialis)?
How long does Tadalafil (Cialis) work for?
How long does Tadalafil (Cialis) work for?
How does food affect the absorption of Tadalafil (Cialis)?
How does food affect the absorption of Tadalafil (Cialis)?
Which PDE5 inhibitor has the shortest 'Kick In' time?
Which PDE5 inhibitor has the shortest 'Kick In' time?
What enzyme degrades cGMP and essentially prevents smooth muscle relaxation, leading to erection?
What enzyme degrades cGMP and essentially prevents smooth muscle relaxation, leading to erection?
What is the main effect of PDE5 inhibitors like Viagra and Levitra?
What is the main effect of PDE5 inhibitors like Viagra and Levitra?
What are some common side effects of PDE5 inhibitors?
What are some common side effects of PDE5 inhibitors?
What is NAION, a condition associated with PDE5 inhibitors?
What is NAION, a condition associated with PDE5 inhibitors?
Why should nitrates be avoided after taking PDE5 inhibitors like Tadalafil, Sildenafil, or Vardenafil?
Why should nitrates be avoided after taking PDE5 inhibitors like Tadalafil, Sildenafil, or Vardenafil?
What does Protein Kinase G do in smooth muscle?
What does Protein Kinase G do in smooth muscle?
