10 Questions
What are the mechanisms involved in chemotoxicity due to contrast media?
Enzyme blocking, Immune system activation, Complement activation
How does osmotoxicity result from contrast media?
Osmotic movement of water and increased plasma volume
What effect does high viscosity of contrast media have on blood vessels?
Nitric Oxide release and vessel dilation
How can osmotoxicity be reduced?
Reducing the number of particles in solution
What effect does warming contrast media have on its viscosity?
Decreases viscosity
Which of the following is NOT a feature of a mild contrast reaction?
Bronchospasm
What is the underlying mechanism behind an anaphylactic reaction to contrast media?
An inappropriate immune response due to sensitization to the contrast agent
What is the main purpose of the immune system's response in an anaphylactic reaction to contrast media?
To stop the contrast agent from getting across the body and neutralize it
What is the role of IgE antibodies in an anaphylactic reaction to contrast media?
IgE binds to receptors on mast cells and basophils, causing the release of active chemical substances
What is the key difference between an anaphylactic reaction and an anaphylactoid reaction to contrast media?
Anaphylactoid reactions do not involve IgE antibodies, while anaphylactic reactions are mediated by IgE
Learn about the chemical and osmotic effects of contrast media in the body. Understand the mechanisms of chemotoxicity and osmotoxicity, including protein binding, enzyme blocking, immune system activation, and osmotic movement of water. Discover how reducing osmolarity can help minimize osmotic toxicity.
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