Physiology of Contrast Media: Chemotoxicity and Osmotoxicity Explained
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Questions and Answers

What are the mechanisms involved in chemotoxicity due to contrast media?

  • Red blood cell lysis, Vessel wall thinning, Platelet aggregation
  • Plasma volume reduction, Pain reduction, Circulatory overload prevention
  • Enzyme blocking, Immune system activation, Complement activation (correct)
  • Protein binding, Enzyme activation, Nitric Oxide release

How does osmotoxicity result from contrast media?

  • Protein aggregation and pain reduction
  • Immune system suppression and redness in blood vessels
  • Decreased plasma volume and blood vessel constriction
  • Osmotic movement of water and increased plasma volume (correct)

What effect does high viscosity of contrast media have on blood vessels?

  • Constriction and pain
  • Nitric Oxide release and vessel dilation (correct)
  • Enzyme blocking and immune system activation
  • Plasma volume reduction and redness

How can osmotoxicity be reduced?

<p>Reducing the number of particles in solution (D)</p> Signup and view all the answers

What effect does warming contrast media have on its viscosity?

<p>Decreases viscosity (A)</p> Signup and view all the answers

Which of the following is NOT a feature of a mild contrast reaction?

<p>Bronchospasm (B)</p> Signup and view all the answers

What is the underlying mechanism behind an anaphylactic reaction to contrast media?

<p>An inappropriate immune response due to sensitization to the contrast agent (B)</p> Signup and view all the answers

What is the main purpose of the immune system's response in an anaphylactic reaction to contrast media?

<p>To stop the contrast agent from getting across the body and neutralize it (A)</p> Signup and view all the answers

What is the role of IgE antibodies in an anaphylactic reaction to contrast media?

<p>IgE binds to receptors on mast cells and basophils, causing the release of active chemical substances (B)</p> Signup and view all the answers

What is the key difference between an anaphylactic reaction and an anaphylactoid reaction to contrast media?

<p>Anaphylactoid reactions do not involve IgE antibodies, while anaphylactic reactions are mediated by IgE (C)</p> Signup and view all the answers

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