Physiology Chapters 6 and 7

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Local Communication

Methods of cell-to-cell signaling within a tissue and localized area without involving the bloodstream.

3 Forms of Local Communication

Gap junctions, contact-dependent signaling, and paracrine signaling.

Signal Transduction Steps

Reception, transduction, response, and termination.

Membrane Receptors

Receptors that transduce signals across the cell membrane.

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4 Membrane Receptor Categories

Ligand-gated ion channels, enzyme-linked receptors, G protein-coupled receptors (GPCRs), and integrin receptors.

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Signal Amplification

A small signal causing a much larger response by activating many effector molecules.

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GPCR-phospholipase C Pathway

A signal transduction pathway involving a G protein, phospholipase C, and intracellular messengers like IP3 and DAG.

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Calcium as Intracellular Messenger

Calcium ions carry signals within cells, triggering various responses.

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Receptor Saturation

All receptor sites are occupied; no further response possible.

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Receptor Specificity

A receptor only binds to certain specific ligands.

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Receptor Competition

Different ligands can compete for the same receptor.

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Cannon's 4 Postulates

Describes the physiological responses of the body to environmental stressors.

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Endocrine vs. Nervous System

Compare and contrast their signaling mechanisms, speed, target cells and other attributes.

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Peptide Hormone Synthesis

Synthesized in the rough ER, processed in the Golgi apparatus.

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Steroid Hormone Action

Diffuse across cell membranes, bind to intracellular receptors to affect gene expression.

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Amine Hormone Example

Hormone synthesized from amino acids, with specific transport and receptor mechanisms.

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Simple Endocrine Reflex

A simple endocrine pathway that includes a stimulus, sensor, input signal, integrating center, output signal, target, and response.

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Hypothalamic Hormones

Hormones released from hypothalamus to regulate other endocrine glands.

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Long-Loop vs. Short-Loop Negative Feedback

The difference in the place of the signal activation in a negative feedback.

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Hormone Synergism

When two hormones act together to produce an effect greater than the sum of their individual effects.

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Hormone Permissiveness

One hormone can enhance the responsiveness of a target cell to a second hormone.

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Hormone Antagonism

When one hormone opposes the action of another.

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Graves' Disease

An autoimmune disorder leading to overproduction of thyroid hormone.

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Myelin Sheath

Insulating layer around some nerve fibers, increasing speed of signal transmission.

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Saltatory Conduction

Action potentials jumping between nodes of Ranvier.

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Graded Potential

Localized changes in membrane potential that vary in size.

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Action Potential

Large, rapid change in membrane potential that propagates along the axon.

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Graded Potential Signal Loss

Leakage of ions through the membrane as the signal travels.

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All-or-Nothing Principle

An action potential either occurs completely or does not occur at all above a threshold.

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Absolute Refractory Period

Time when another action potential is impossible, regardless of stimulus strength.

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Relative Refractory Period

Time when a stronger-than-normal stimulus is required to trigger another action potential.

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Action Potential Steps

Depolarization, repolarization, and hyperpolarization.

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Chemical Synapse Steps

Action potential arrival, neurotransmitter release, neurotransmitter binding, postsynaptic potential, and neurotransmitter termination.

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Neurotransmitter Termination

Neurotransmitters can be degraded, taken up by cells, or diffuse away.

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EPSP and IPSP

Excitatory postsynaptic potential (EPSP) and inhibitory postsynaptic potential (IPSP) are graded potentials.

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Blood-Brain Barrier

Tight junctions in brain capillaries forming a barrier for substances in the blood.

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Cranial Nerves

12 pairs of nerves that originate from the brain or brainstem.

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3 Local Communication Forms

Gap junctions, contact-dependent signaling, and paracrine signaling.

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Signal Pathway Steps

Reception, transduction, response, and termination.

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Membrane Receptor Categories

Ligand-gated ion channels, enzyme-linked receptors, GPCRs, and integrin receptors.

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Signal Amplification

A small signal causing a large response by activating many effector molecules.

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GPCR-phospholipase C Pathway

Signal transduction using G proteins, phospholipase C, IP3 and DAG for cellular signal.

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Calcium Intracellular Messenger

Calcium ions trigger responses within cells.

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Receptor Saturation

All receptor sites are occupied; no more signal reception.

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Receptor Specificity

A receptor binds only to certain ligands.

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Receptor Competition

Different ligands compete for the same receptor.

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Cannon's 4 Postulates

Describes physiological responses to stress.

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Endocrine vs. Nervous System

Compare signaling mechanisms, speed, targets.

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Peptide Hormone Synthesis

Synthesized in the rough ER, processed in Golgi.

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Steroid Hormone Action

Steroid hormones cross membranes and affect gene expression.

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Amine Hormone Example

Hormone from amino acids, specific transport and receptor.

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Simple Endocrine Reflex

Pathway includes stimulus, sensor, target, etc.

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Hypothalamic Hormones

Hormones from the hypothalamus controlling other glands.

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Long-Loop vs. Short-Loop Feedback

Difference in feedback mechanisms in response to hormones.

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Hormone Synergism

Two hormones with a greater effect.

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Hormone Permissiveness

One hormone enhances the response of another.

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Hormone Antagonism

One hormone opposes another.

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Graves' Disease

Autoimmune disorder causing high thyroid hormone.

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Myelin Sheath

Insulating layer around nerves, speeding signal.

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Saltatory Conduction

Action potentials jump along myelinated axons.

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Graded Potential

Localized changes in membrane potential.

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Action Potential

Large, rapid change in membrane potential.

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Graded Potential Signal Loss

Ions leak out as a signal travels.

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All-or-Nothing Principle

Action potential either happens completely or not.

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Absolute Refractory Period

Time when another action potential is impossible.

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Relative Refractory Period

Stronger stimulus needed to trigger an action potential.

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Action Potential Steps

Depolarization, repolarization, and hyperpolarization.

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Chemical Synapse Steps

Arrival, neurotransmitter release, binding, postsynaptic potential, and termination.

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Neurotransmitter Termination

Neurotransmitters degraded, taken up, or diffused.

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EPSP and IPSP

Excitatory and inhibitory postsynaptic potentials.

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Blood-Brain Barrier

Tight junctions in brain capillaries, limiting blood substance access to the brain.

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Cranial Nerves

12 pairs of nerves connecting the brain to the head and neck.

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Brain Stem Functions

Functions like breathing control (among others).

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Diencephalon Components

Thalamus and hypothalamus.

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Hypothalamus Functions

Controls basic functions and regulates hormone system.

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Limbic System Components

Structures that regulate emotions and memory.

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Cerebral Cortex Functional Areas

Motor, sensory, and association areas.

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Cerebral Lateralization

Different hemispheres specializing in functions.

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Long-Term Memory Types

Declarative and non-declarative (procedural) memories.

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Study Notes

Chapter 6

  • Local communication forms: Describe 3 forms and give a physiological example for each.
  • Signal transduction pathway steps: Detail the 5 steps.
  • Membrane receptor categories: Describe the 4 types.
  • Signal amplification: Explain and mention its physiological importance.
  • G protein-coupled receptor (GPCR)-phospholipase C pathway: Describe the pathway.
  • Calcium as an intracellular messenger: Explain its role.
  • Receptor concepts: Define saturation, specificity, and competition.
  • Cannon's postulates: Outline Cannon's 4 postulates.
  • Endocrine vs nervous system: Compare and contrast the two systems.

Chapter 7

  • Peptide hormone synthesis and processing: Explain the process and provide an example.
  • Steroid hormone action: Describe how steroid hormones reach and act on target cells, including an example.
  • Amine hormone example: Provide an example, describe its release, transport, receptor location, and response to binding.
  • Simple endocrine reflex: Give an example (refer to Figure 7.7a).
  • Hypothalamic hormones and pathways: List 2 hypothalamic hormones and their pathway to target tissues (refer to Figure 7.9).
  • Hormone feedback types: Differentiate long-loop and short-loop negative feedback, with examples.
  • Hormone interactions: Define synergism, permissiveness, and antagonism with examples.

Chapter 8

  • Myelin sheath: Explain its composition, role of cells involved, and significance of saltatory conduction.
  • Graded vs Action potentials: Distinguish between graded and action potentials, and include differences in strength.
  • Graded potential strength loss: Explain why graded potentials lose strength.
  • All-or-none principle of action potentials: Describe the principle and its dependence on threshold potential.
  • Action potential steps: Outline the various steps in an action potential, including ion flow.
  • Refractory periods: Define and differentiate absolute and relative refractory periods.
  • Chemical synapse steps: Explain the steps involved in chemical synapse transmission.
  • Neurotransmitter termination methods: List 3 ways neurotransmitters can be terminated.
  • IPSP vs EPSP: Compare and contrast inhibitory and excitatory postsynaptic potentials.

Chapter 9

  • Blood-brain barrier: Describe its formation and significance.
  • Cranial nerves: List the 12 cranial nerves (likely a matching question).
  • Brain stem functions: Describe the functions of different areas in the brain stem.
  • Diencephalon components: Explain the components of the diencephalon.
  • Hypothalamus functions: Describe the functions of the hypothalamus, including its specific mechanisms.
  • Limbic system components and functions: Explain the components and functions of the limbic system.
  • Cerebral cortex functions: Identify the functional areas of the cerebral cortex and their locations (refer to Figure 9.13).
  • Cerebral lateralization: Define the term.
  • Long-term memory types: Describe 2 types of long-term memory.

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