Physiology Chapter on Respiratory Acidosis
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Questions and Answers

What is the primary effect of acetylcholine on the airways?

  • Reduced inflammation of the lung tissue
  • Bronchodilation via beta-2 receptor activation
  • Increased lung compliance and elasticity
  • Bronchoconstriction via activation of parasympathetic pathways (correct)
  • Which of the following describes the effect of increased altitude on oxygen availability?

  • Both the partial pressure and the concentration of oxygen decrease at higher altitudes reducing oxygen availability
  • The concentration of oxygen remains constant, but the reduced atmospheric pressure diminishes the driving force for oxygen entry into the lungs (correct)
  • Increased atmospheric pressure leading to an increase in the partial pressure of oxygen, increasing oxygen availability
  • The partial pressure of oxygen decreases, leading to a reduction in oxygen availability
  • If a patient has a condition that decreases lung compliance, what is the primary physiologic effect on breathing?

  • The lungs have an enhanced capacity for gas exchange.
  • The lungs expand too easily and have difficulty recoiling during expiration.
  • The lungs have reduced airway resistance, leading to easier airflow.
  • The lungs lose their elasticity and become stiff, making it more difficult to inspire. (correct)
  • A medication that is a beta-2 agonist, such as albuterol, has its therapeutic effect by:

    <p>Stimulating beta-2 receptors to cause bronchodilation (C)</p> Signup and view all the answers

    What is the primary role of the medulla in the mechanics of breathing?

    <p>Detection of serum carbon dioxide (CO2) and triggering an increase in respiration rate. (A)</p> Signup and view all the answers

    In response to respiratory acidosis, which of the following actions does the medulla oblongata initiate?

    <p>Forced expiration to reduce serum CO2 levels (A)</p> Signup and view all the answers

    What is the primary renal response to respiratory acidosis?

    <p>Increased reabsorption of bicarbonate from glomerular filtrate (C)</p> Signup and view all the answers

    Which of the following conditions would NOT result in a right shift of the hemoglobin-oxygen dissociation curve?

    <p>Hypothermia (B)</p> Signup and view all the answers

    According to Boyle's Law, if the volume of a gas increases, the pressure will:

    <p>Decrease proportionally (C)</p> Signup and view all the answers

    Which of the following is a primary characteristic of obstructive lung disease?

    <p>Increased airway resistance (B)</p> Signup and view all the answers

    Which of these is NOT one of the 'Big 3' obstructive lung diseases?

    <p>Pulmonary Fibrosis (B)</p> Signup and view all the answers

    Which statement best describes the significance of Boyle's Law in respiration?

    <p>It establishes the basis for the movement of air into and out of lungs (A)</p> Signup and view all the answers

    Which of the following describes Type II alveoli?

    <p>Produce and secrete surfactant; not as highly vascularized. (A)</p> Signup and view all the answers

    What is the primary mechanism behind bronchoconstriction in asthma?

    <p>Increased IgE levels (B)</p> Signup and view all the answers

    What is the primary function of surfactant within the alveoli?

    <p>To equally distribute water molecules and lower surface tension (C)</p> Signup and view all the answers

    Which of these cellular changes is most associated with COPD?

    <p>Activation of macrophages, neutrophils and fibroblasts (C)</p> Signup and view all the answers

    What is the most common cause of pneumonia in COPD patients?

    <p>Streptococcus pneumoniae (B)</p> Signup and view all the answers

    What effect does increased elevation have on respiratory function?

    <p>Decreases oxygen partial pressure, thus decreasing its diffusion across a membrane (B)</p> Signup and view all the answers

    What is the underlying cause of Cor Pulmonale?

    <p>Pulmonary hypertension (A)</p> Signup and view all the answers

    Which best describes the FEV1/FVC ratio in restrictive lung disease?

    <p>Usually normal (A)</p> Signup and view all the answers

    Which of the following is a key characteristic of restrictive lung disease?

    <p>Decreased lung expansion (C)</p> Signup and view all the answers

    Which of the following correctly describes a wheal?

    <p>An elevated, irregularly shaped area of cutaneous edema (D)</p> Signup and view all the answers

    What is a characteristic feature of a vesicle?

    <p>Elevated and well-circumscribed, often painful to touch (A)</p> Signup and view all the answers

    Which of the following skin lesions is NOT typically associated with telangiectasia?

    <p>Urticaria (C)</p> Signup and view all the answers

    What type of skin lesion is primarily identified as having irregular margins and is greater than 1 cm?

    <p>Patch (B)</p> Signup and view all the answers

    Which skin infection is often associated with insect bites and classified as a zoonotic infection?

    <p>Rocky Mountain Spotted Fever (B)</p> Signup and view all the answers

    What is the name of the deepest layer of the epidermis?

    <p>Stratum Basale (D)</p> Signup and view all the answers

    Which layer of the epidermis is responsible for producing melanin?

    <p>Stratum Basale (D)</p> Signup and view all the answers

    What is the function of the stratum granulosum?

    <p>Moisture retention (A)</p> Signup and view all the answers

    Which layer of the epidermis is only found in areas of thickened skin like the palms and soles?

    <p>Stratum Lucidum (C)</p> Signup and view all the answers

    Which of the following is NOT a function of the epidermis?

    <p>Regulation of body temperature (C)</p> Signup and view all the answers

    Which layer of the epidermis contains Langerhans cells?

    <p>Stratum Spinosum (B)</p> Signup and view all the answers

    Which of the following is an example of a macule?

    <p>A freckle (A)</p> Signup and view all the answers

    What is the difference between a macule and a papule?

    <p>Macules are changes in skin color, while papules are raised lesions. (D)</p> Signup and view all the answers

    Which type of pneumoconiosis is the most common?

    <p>Coal Miner's pneumoconiosis (D)</p> Signup and view all the answers

    What is the primary immunological mechanism involved in hypersensitivity pneumonitis?

    <p>Type III hypersensitivity (D)</p> Signup and view all the answers

    What is a significant consequence of the granulomas formed in sarcoidosis?

    <p>Hypervitaminosis D (D)</p> Signup and view all the answers

    What is a hallmark finding in ARDS that impairs gas exchange?

    <p>Alveolar wall fibrosis (C)</p> Signup and view all the answers

    Which condition can lead to tension pneumothorax?

    <p>Chest wall trauma (C)</p> Signup and view all the answers

    Which neuromuscular disease is associated with pulmonary complications due to anti-nicotinic acetylcholine receptor antibodies?

    <p>Myasthenia Gravis (D)</p> Signup and view all the answers

    Which of the following is a common cause of ARDS?

    <p>Acute pancreatitis (C)</p> Signup and view all the answers

    What does a tension pneumothorax primarily cause?

    <p>Mediastinal shift (A)</p> Signup and view all the answers

    Flashcards

    How does the body respond to respiratory acidosis?

    The medulla, a part of the brainstem, receives signals from receptors in the aorta and carotid sinus about low blood pH (acidosis). This information triggers the medulla to increase breathing rate and depth, forcing more CO2 out of the body. This process helps restore blood pH to normal.

    How do the kidneys respond to respiratory acidosis?

    The kidneys play a key role in regulating blood pH by reabsorbing bicarbonate from the urine back into the bloodstream. This process helps to neutralize the excess acid in the blood, restoring pH balance.

    What causes a right shift of the hemoglobin-oxygen dissociation curve?

    Sepsis, systemic inflammation, hypoxia, hypotension, hypovolemia, hyperthermia, and acidosis all shift the hemoglobin-oxygen dissociation curve to the right. This means that at a given oxygen partial pressure, hemoglobin releases more oxygen to the tissues.

    What is Boyle's Law?

    Boyle's Law states that pressure and volume have an inverse relationship. When one goes up, the other goes down. This is important for breathing because it creates pressure differences that allow air to move into and out of the lungs.

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    What are Type I alveoli?

    Type I alveoli are thin-walled structures that are specialized for gas exchange. They have a rich blood supply to facilitate this process.

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    What are Type II alveoli?

    Type II alveoli are smaller and responsible for producing surfactant, a substance that reduces surface tension in the alveoli, allowing for efficient gas exchange.

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    What is surfactant?

    Surfactant is a special substance that lowers surface tension in the alveoli. This helps prevent smaller alveoli from collapsing, ensuring that all alveoli can participate in gas exchange.

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    How does increased elevation affect breathing?

    At higher elevations, the air pressure is lower. This means that there is less oxygen available for the lungs to take in. This can lead to shortness of breath and reduced physical performance.

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    Lung Compliance

    The ability of the lungs to expand during inspiration and recoil during expiration.

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    Restrictive Lung Disease

    A decrease in lung compliance, making it harder for lungs to expand.

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    Atmospheric Pressure

    The pressure exerted by the weight of the air above us. It decreases at higher altitudes.

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    Sympathetic Nervous System & Bronchodilation

    The sympathetic nervous system's role in controlling airway diameter. Beta-2 agonists (like albuterol) mimic the action of the sympathetic nervous system, promoting bronchodilation.

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    Parasympathetic Nervous System & Bronchoconstriction

    The parasympathetic nervous system's role in controlling airway diameter. Parasympathetic activation (via the vagus nerve) releases acetylcholine, causing bronchoconstriction.

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    Obstructive Lung Disease

    A group of lung diseases characterized by increased airway resistance, leading to difficulty breathing out (expiring) and causing mild oxygen deficiency (hypoxia) and significant carbon dioxide retention.

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    Asthma

    A common condition affecting the airways, often caused by allergens or environmental triggers. It involves inflammation and narrowing of the bronchi, making it difficult to breathe, especially during exhalation.

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    Emphysema

    A chronic lung disease characterized by irreversible damage to the alveoli (air sacs), leading to decreased lung surface area for gas exchange and increased difficulty breathing.

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    Chronic Obstructive Pulmonary Disease (COPD)

    A chronic inflammatory lung disease caused primarily by smoking, leading to airway narrowing and increased mucus production. It makes it difficult to breathe out and can lead to frequent lung infections.

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    Cor Pulmonale

    Right-sided heart failure caused by high blood pressure in the pulmonary arteries (pulmonary hypertension). This makes it difficult for the right ventricle to pump blood into the lungs efficiently.

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    Community-Acquired Pneumonia (CAP)

    A type of pneumonia that occurs in the community and is often caused by the bacteria Streptococcus pneumoniae.

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    FEV1/FVC Ratio

    The ratio of forced expiratory volume in one second (FEV1) to forced vital capacity (FVC), used to assess lung function. In obstructive lung diseases, this ratio is decreased due to difficulty expiring air.

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    What is a patch?

    A type of skin lesion that is greater than 1cm in diameter and has an irregular shape, meaning it is not well-defined or circular.

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    What is a wheal?

    An elevated skin lesion caused by fluid buildup in the dermis, often associated with allergies or insect bites.

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    What is a vesicle?

    An elevated, well-circumscribed skin lesion, usually filled with clear fluid, that does not extend deep into the skin.

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    What are telangiectasias?

    Fine, irregular skin lesions caused by dilated blood vessels, sometimes appearing in a "spider-like" pattern.

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    What are zoonotic infections?

    Infections transmitted to humans from animals or insects.

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    Epidermis

    The outermost layer of skin, lacking blood supply. It is made up of dead, keratinized cells and is responsible for protecting the body from the environment.

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    Dermis

    The middle layer of skin, containing blood vessels, nerves, and hair follicles.

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    Hypodermis (Subcutaneous layer)

    The deepest layer of skin, composed of fat and connective tissue. It provides insulation and cushioning.

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    Macule

    A well-defined, flat skin discoloration, usually less than 1 cm in diameter.

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    Papule

    A small, raised bump on the skin, less than 1 cm in diameter.

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    Stratum Corneum

    The most superficial layer of the epidermis. It's made up of dead, flat cells filled with keratin.

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    Stratum Lucidum

    A layer of the epidermis found only in areas of thick skin, like the palms of the hands and soles of the feet. It helps protect the skin from wear and tear.

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    Stratum Granulosum

    This layer of the epidermis contains granules that help seal moisture in the skin.

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    Berylliosis

    A type of pneumoconiosis caused by exposure to beryllium, often seen in workers handling the metal. It causes inflammation and scarring in the lungs, leading to shortness of breath and other respiratory problems.

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    Silicosis

    A type of pneumoconiosis caused by inhaling silica dust, commonly found in mining, construction, and sandblasting. It results in scar tissue formation in the lungs, impairing lung function.

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    Asbestosis

    A type of pneumoconiosis caused by exposure to asbestos fibers, leading to scarring and inflammation in the lungs, increasing the risk of lung cancer and mesothelioma.

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    Coal Miner's Pneumoconiosis

    A type of pneumoconiosis that is the most common, usually found in coal miners due to prolonged exposure to coal dust. It causes inflammation and scarring in the lungs, leading to breathing difficulties.

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    Hypersensitivity Pneumonitis

    A type of lung inflammation caused by an allergic reaction to inhaled substances, often fungal spores or dust. It is a Type III hypersensitivity reaction involving immune complex deposition and inflammation in the lungs.

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    Sarcoidosis

    A chronic inflammatory disease that can affect multiple organs, including the lungs, skin, eyes, and lymph nodes. It is characterized by the formation of granulomas (small clumps of inflammatory cells) in the affected tissues.

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    ARDS (Acute Respiratory Distress Syndrome)

    Also known as the 'wet lung', this is a severe lung condition characterized by diffuse inflammation within the lungs. It often occurs as a complication of serious injuries, infections, or other conditions.

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    Pneumothorax

    This is a condition where air escapes from the lungs into the space between the lung and the chest wall, resulting in a collapsed lung. Tension pneumothorax occurs when pressure builds up within this space, compressing the lung and heart, impairing breathing and circulation.

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    Study Notes

    Physiological Response to Respiratory Acidosis

    • The medulla (central chemoreceptor) receives input from peripheral chemoreceptors (aorta, carotid sinus)
    • This induces forced expiration to reduce serum CO2 levels, normalizing blood pH
    • Kidneys (specifically the proximal convoluted tubule) increase bicarbonate reabsorption from glomerular filtrate (urine) to normalize blood pH

    Hemoglobin-Oxygen Dissociation Curve Shift Factors

    • Sepsis (systemic inflammatory response syndrome)
    • Hypoxia
    • Hypotension/hypovolemia
    • Hyperthermia/fever
    • Causes of acidosis

    Boyle's Law

    • Pressure and volume are inversely proportional
    • Pressure gradient between atmospheric and intrapulmonary pressure drives air movement
    • Smaller alveoli require surfactant for equal gas exchange with larger alveoli

    Alveolar Subtypes

    • Type I Alveoli: directly participate in gas exchange, highly vascularized
    • Type II Alveoli: produce and secrete surfactant, not as highly vascularized

    Surfactant Purpose

    • Lowers surface tension
    • Equally distributes water molecules across inner alveolar wall
    • Allows smaller alveoli to overcome higher pressure gradient and participate in gas exchange

    Effect of Elevation on Respiration

    • Atmospheric pressure drops with higher elevations
    • Driving force for oxygen also drops, making inspiration more difficult.

    Lung Compliance

    • Elasticity of the lung, important for measuring lung expansion during inspiration and recoil during expiration
    • Decreased lung compliance indicates decreased lung elasticity

    Restrictive Lung Disease Factors

    • Increased activation of macrophages and neutrophils
    • Release of pro-inflammatory cytokines
    • Activation of fibroblasts leading to pulmonary fibrosis which results in decreased lung compliance and decreased lung expansion

    Causes of Respiratory Distress Syndrome (ARDS)

    • Primary lung conditions like chest wall trauma, severe pneumonia, and exposure to noxious gases or heavy metals
    • Secondary conditions like sepsis, systemic inflammatory response syndrome (SIRS), acute pancreatitis, or appendicitis
    • Pneumothorax (presence of air or fluid resulting in increased intrapleural pressure), which can lead to tension pneumothorax causing mediastinal shift of the heart and potentially cardiac arrest

    Neuromuscular Diseases Associated with Pulmonary Disease

    • Information not provided

    Pathophysiology of Asthma and COPD

    • Asthma: largely genetic, epigenetic factors involved, bronchoconstriction secondary to environmental stimuli like allergies or environmental factors (exercise, cold weather)
    • COPD: largely due to smoking, irreversible destruction of alveoli, decreased gas exchange, pulmonary fibrosis
    • Asthma: hyper-eosinophilia, increased IgE levels, increased histamine levels, secondary to mast cell and basophil degranulation; decreased FEV1/FVC ratio
    • COPD: increased macrophage-neutrophil-fibroblast activation, resulting in bronchial airway edema, increased thickness of alveolar membrane due to collagen production, bronchoconstriction, increased mucus production; decreased FEV1/FVC ratio
    • Emphysema: widespread destruction of Type I and II alveoli, increased fibrosis

    Causes of Pneumonia in COPD Patients

    • Community-Acquired Pneumonia (CAP) caused by Streptococcus pneumoniae

    Cor Pulmonale

    • Right-sided heart failure due to pulmonary hypertension
    • Bilateral lower extremity edema occurs first, followed by eventual complication of left sided heart failure

    Common Skin Lesion Types

    • Macule: Flat, skin lesion, color change, less than 1 cm
    • Papule: Small raised lesion less than 1 cm
    • Patch: Macular lesion greater than 1 cm
    • Wheal: Elevated, irregularly shaped; edema associated with allergies or insect bites
    • Urticaria: Wheals
    • Vesicle: Elevated, well-circumscribed superficial lesion

    Common Skin Infections

    • Zoonotic Infections (Rocky Mountain Spotted Fever, Lyme disease, spider bites, mosquito-borne infections)
    • Herpes Simplex viruses, Herpes Zoster, Varicella (chicken pox)

    Histologic Components of the Skin

    • Epidermis
    • Dermis
    • Subcutaneous layer (hypodermis)

    Layers of the Epidermis

    • Stratum Corneum
    • Stratum Lucidum
    • Stratum Granulosum
    • Stratum Spinosum
    • Stratum Basale

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    Description

    Test your understanding of the physiological responses to respiratory acidosis and the factors affecting the hemoglobin-oxygen dissociation curve. This quiz covers key concepts including Boyle's Law, alveolar types, and the role of the medulla and kidneys in pH regulation.

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