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Questions and Answers
What is the primary effect of acetylcholine on the airways?
What is the primary effect of acetylcholine on the airways?
Which of the following describes the effect of increased altitude on oxygen availability?
Which of the following describes the effect of increased altitude on oxygen availability?
If a patient has a condition that decreases lung compliance, what is the primary physiologic effect on breathing?
If a patient has a condition that decreases lung compliance, what is the primary physiologic effect on breathing?
A medication that is a beta-2 agonist, such as albuterol, has its therapeutic effect by:
A medication that is a beta-2 agonist, such as albuterol, has its therapeutic effect by:
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What is the primary role of the medulla in the mechanics of breathing?
What is the primary role of the medulla in the mechanics of breathing?
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In response to respiratory acidosis, which of the following actions does the medulla oblongata initiate?
In response to respiratory acidosis, which of the following actions does the medulla oblongata initiate?
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What is the primary renal response to respiratory acidosis?
What is the primary renal response to respiratory acidosis?
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Which of the following conditions would NOT result in a right shift of the hemoglobin-oxygen dissociation curve?
Which of the following conditions would NOT result in a right shift of the hemoglobin-oxygen dissociation curve?
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According to Boyle's Law, if the volume of a gas increases, the pressure will:
According to Boyle's Law, if the volume of a gas increases, the pressure will:
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Which of the following is a primary characteristic of obstructive lung disease?
Which of the following is a primary characteristic of obstructive lung disease?
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Which of these is NOT one of the 'Big 3' obstructive lung diseases?
Which of these is NOT one of the 'Big 3' obstructive lung diseases?
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Which statement best describes the significance of Boyle's Law in respiration?
Which statement best describes the significance of Boyle's Law in respiration?
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Which of the following describes Type II alveoli?
Which of the following describes Type II alveoli?
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What is the primary mechanism behind bronchoconstriction in asthma?
What is the primary mechanism behind bronchoconstriction in asthma?
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What is the primary function of surfactant within the alveoli?
What is the primary function of surfactant within the alveoli?
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Which of these cellular changes is most associated with COPD?
Which of these cellular changes is most associated with COPD?
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What is the most common cause of pneumonia in COPD patients?
What is the most common cause of pneumonia in COPD patients?
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What effect does increased elevation have on respiratory function?
What effect does increased elevation have on respiratory function?
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What is the underlying cause of Cor Pulmonale?
What is the underlying cause of Cor Pulmonale?
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Which best describes the FEV1/FVC ratio in restrictive lung disease?
Which best describes the FEV1/FVC ratio in restrictive lung disease?
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Which of the following is a key characteristic of restrictive lung disease?
Which of the following is a key characteristic of restrictive lung disease?
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Which of the following correctly describes a wheal?
Which of the following correctly describes a wheal?
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What is a characteristic feature of a vesicle?
What is a characteristic feature of a vesicle?
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Which of the following skin lesions is NOT typically associated with telangiectasia?
Which of the following skin lesions is NOT typically associated with telangiectasia?
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What type of skin lesion is primarily identified as having irregular margins and is greater than 1 cm?
What type of skin lesion is primarily identified as having irregular margins and is greater than 1 cm?
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Which skin infection is often associated with insect bites and classified as a zoonotic infection?
Which skin infection is often associated with insect bites and classified as a zoonotic infection?
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What is the name of the deepest layer of the epidermis?
What is the name of the deepest layer of the epidermis?
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Which layer of the epidermis is responsible for producing melanin?
Which layer of the epidermis is responsible for producing melanin?
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What is the function of the stratum granulosum?
What is the function of the stratum granulosum?
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Which layer of the epidermis is only found in areas of thickened skin like the palms and soles?
Which layer of the epidermis is only found in areas of thickened skin like the palms and soles?
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Which of the following is NOT a function of the epidermis?
Which of the following is NOT a function of the epidermis?
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Which layer of the epidermis contains Langerhans cells?
Which layer of the epidermis contains Langerhans cells?
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Which of the following is an example of a macule?
Which of the following is an example of a macule?
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What is the difference between a macule and a papule?
What is the difference between a macule and a papule?
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Which type of pneumoconiosis is the most common?
Which type of pneumoconiosis is the most common?
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What is the primary immunological mechanism involved in hypersensitivity pneumonitis?
What is the primary immunological mechanism involved in hypersensitivity pneumonitis?
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What is a significant consequence of the granulomas formed in sarcoidosis?
What is a significant consequence of the granulomas formed in sarcoidosis?
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What is a hallmark finding in ARDS that impairs gas exchange?
What is a hallmark finding in ARDS that impairs gas exchange?
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Which condition can lead to tension pneumothorax?
Which condition can lead to tension pneumothorax?
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Which neuromuscular disease is associated with pulmonary complications due to anti-nicotinic acetylcholine receptor antibodies?
Which neuromuscular disease is associated with pulmonary complications due to anti-nicotinic acetylcholine receptor antibodies?
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Which of the following is a common cause of ARDS?
Which of the following is a common cause of ARDS?
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What does a tension pneumothorax primarily cause?
What does a tension pneumothorax primarily cause?
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Flashcards
How does the body respond to respiratory acidosis?
How does the body respond to respiratory acidosis?
The medulla, a part of the brainstem, receives signals from receptors in the aorta and carotid sinus about low blood pH (acidosis). This information triggers the medulla to increase breathing rate and depth, forcing more CO2 out of the body. This process helps restore blood pH to normal.
How do the kidneys respond to respiratory acidosis?
How do the kidneys respond to respiratory acidosis?
The kidneys play a key role in regulating blood pH by reabsorbing bicarbonate from the urine back into the bloodstream. This process helps to neutralize the excess acid in the blood, restoring pH balance.
What causes a right shift of the hemoglobin-oxygen dissociation curve?
What causes a right shift of the hemoglobin-oxygen dissociation curve?
Sepsis, systemic inflammation, hypoxia, hypotension, hypovolemia, hyperthermia, and acidosis all shift the hemoglobin-oxygen dissociation curve to the right. This means that at a given oxygen partial pressure, hemoglobin releases more oxygen to the tissues.
What is Boyle's Law?
What is Boyle's Law?
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What are Type I alveoli?
What are Type I alveoli?
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What are Type II alveoli?
What are Type II alveoli?
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What is surfactant?
What is surfactant?
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How does increased elevation affect breathing?
How does increased elevation affect breathing?
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Lung Compliance
Lung Compliance
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Restrictive Lung Disease
Restrictive Lung Disease
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Atmospheric Pressure
Atmospheric Pressure
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Sympathetic Nervous System & Bronchodilation
Sympathetic Nervous System & Bronchodilation
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Parasympathetic Nervous System & Bronchoconstriction
Parasympathetic Nervous System & Bronchoconstriction
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Obstructive Lung Disease
Obstructive Lung Disease
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Asthma
Asthma
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Emphysema
Emphysema
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Chronic Obstructive Pulmonary Disease (COPD)
Chronic Obstructive Pulmonary Disease (COPD)
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Cor Pulmonale
Cor Pulmonale
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Community-Acquired Pneumonia (CAP)
Community-Acquired Pneumonia (CAP)
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FEV1/FVC Ratio
FEV1/FVC Ratio
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What is a patch?
What is a patch?
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What is a wheal?
What is a wheal?
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What is a vesicle?
What is a vesicle?
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What are telangiectasias?
What are telangiectasias?
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What are zoonotic infections?
What are zoonotic infections?
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Epidermis
Epidermis
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Dermis
Dermis
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Hypodermis (Subcutaneous layer)
Hypodermis (Subcutaneous layer)
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Macule
Macule
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Papule
Papule
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Stratum Corneum
Stratum Corneum
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Stratum Lucidum
Stratum Lucidum
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Stratum Granulosum
Stratum Granulosum
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Berylliosis
Berylliosis
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Silicosis
Silicosis
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Asbestosis
Asbestosis
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Coal Miner's Pneumoconiosis
Coal Miner's Pneumoconiosis
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Hypersensitivity Pneumonitis
Hypersensitivity Pneumonitis
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Sarcoidosis
Sarcoidosis
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ARDS (Acute Respiratory Distress Syndrome)
ARDS (Acute Respiratory Distress Syndrome)
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Pneumothorax
Pneumothorax
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Study Notes
Physiological Response to Respiratory Acidosis
- The medulla (central chemoreceptor) receives input from peripheral chemoreceptors (aorta, carotid sinus)
- This induces forced expiration to reduce serum CO2 levels, normalizing blood pH
- Kidneys (specifically the proximal convoluted tubule) increase bicarbonate reabsorption from glomerular filtrate (urine) to normalize blood pH
Hemoglobin-Oxygen Dissociation Curve Shift Factors
- Sepsis (systemic inflammatory response syndrome)
- Hypoxia
- Hypotension/hypovolemia
- Hyperthermia/fever
- Causes of acidosis
Boyle's Law
- Pressure and volume are inversely proportional
- Pressure gradient between atmospheric and intrapulmonary pressure drives air movement
- Smaller alveoli require surfactant for equal gas exchange with larger alveoli
Alveolar Subtypes
- Type I Alveoli: directly participate in gas exchange, highly vascularized
- Type II Alveoli: produce and secrete surfactant, not as highly vascularized
Surfactant Purpose
- Lowers surface tension
- Equally distributes water molecules across inner alveolar wall
- Allows smaller alveoli to overcome higher pressure gradient and participate in gas exchange
Effect of Elevation on Respiration
- Atmospheric pressure drops with higher elevations
- Driving force for oxygen also drops, making inspiration more difficult.
Lung Compliance
- Elasticity of the lung, important for measuring lung expansion during inspiration and recoil during expiration
- Decreased lung compliance indicates decreased lung elasticity
Restrictive Lung Disease Factors
- Increased activation of macrophages and neutrophils
- Release of pro-inflammatory cytokines
- Activation of fibroblasts leading to pulmonary fibrosis which results in decreased lung compliance and decreased lung expansion
Causes of Respiratory Distress Syndrome (ARDS)
- Primary lung conditions like chest wall trauma, severe pneumonia, and exposure to noxious gases or heavy metals
- Secondary conditions like sepsis, systemic inflammatory response syndrome (SIRS), acute pancreatitis, or appendicitis
- Pneumothorax (presence of air or fluid resulting in increased intrapleural pressure), which can lead to tension pneumothorax causing mediastinal shift of the heart and potentially cardiac arrest
Neuromuscular Diseases Associated with Pulmonary Disease
- Information not provided
Pathophysiology of Asthma and COPD
- Asthma: largely genetic, epigenetic factors involved, bronchoconstriction secondary to environmental stimuli like allergies or environmental factors (exercise, cold weather)
- COPD: largely due to smoking, irreversible destruction of alveoli, decreased gas exchange, pulmonary fibrosis
- Asthma: hyper-eosinophilia, increased IgE levels, increased histamine levels, secondary to mast cell and basophil degranulation; decreased FEV1/FVC ratio
- COPD: increased macrophage-neutrophil-fibroblast activation, resulting in bronchial airway edema, increased thickness of alveolar membrane due to collagen production, bronchoconstriction, increased mucus production; decreased FEV1/FVC ratio
- Emphysema: widespread destruction of Type I and II alveoli, increased fibrosis
Causes of Pneumonia in COPD Patients
- Community-Acquired Pneumonia (CAP) caused by Streptococcus pneumoniae
Cor Pulmonale
- Right-sided heart failure due to pulmonary hypertension
- Bilateral lower extremity edema occurs first, followed by eventual complication of left sided heart failure
Common Skin Lesion Types
- Macule: Flat, skin lesion, color change, less than 1 cm
- Papule: Small raised lesion less than 1 cm
- Patch: Macular lesion greater than 1 cm
- Wheal: Elevated, irregularly shaped; edema associated with allergies or insect bites
- Urticaria: Wheals
- Vesicle: Elevated, well-circumscribed superficial lesion
Common Skin Infections
- Zoonotic Infections (Rocky Mountain Spotted Fever, Lyme disease, spider bites, mosquito-borne infections)
- Herpes Simplex viruses, Herpes Zoster, Varicella (chicken pox)
Histologic Components of the Skin
- Epidermis
- Dermis
- Subcutaneous layer (hypodermis)
Layers of the Epidermis
- Stratum Corneum
- Stratum Lucidum
- Stratum Granulosum
- Stratum Spinosum
- Stratum Basale
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Description
Test your understanding of the physiological responses to respiratory acidosis and the factors affecting the hemoglobin-oxygen dissociation curve. This quiz covers key concepts including Boyle's Law, alveolar types, and the role of the medulla and kidneys in pH regulation.