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Physiology and Pathogenesis of Rickettsial Infections

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Physiology and Pathogenesis of Rickettsial Infections

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Questions and Answers

What are the general properties of Mycoplasma?

Mycoplasma are pleomorphic, 0.2-0.8μm in diameter, facultatively anaerobic, and exhibit a gliding motility pattern.

Describe the physiology of Mycoplasma.

Mycoplasma have a genome consisting of circular double-stranded DNA, require cholesterol and sterols for membrane synthesis, and exhibit a 'fried-egg' appearance when grown on solid media.

List some members of the Mycoplasma family.

Members of the Mycoplasma family include M.pneumoniae, M.hominis, M.genitalium, and U.urealyticum.

What are the clinical findings in Rickettsial Infections?

Fever, headache, malaise, skin rash, enlargement of spleen and liver. Signup and view all the answers

How are rickettsia primarily transmitted?

Rickettsia are primarily transmitted by arthropod vectors such as ticks, fleas, mites, and lice. Signup and view all the answers

Describe the pathogenesis of Rickettsial Infections in terms of where they multiply and the vascular effects they produce.

Rickettsia multiply in endothelial cells of small blood vessels, leading to vasculitis, thrombosis, and necrosis. Vascular lesions are prominent in the skin. Signup and view all the answers

What are the clinical features associated with Rickettsial infections?

Fever, rash, and vasculitis Signup and view all the answers

What are the general properties of Rickettsia in terms of transmission and resistance to environmental conditions?

Rickettsia are transmitted by arthropod vectors and Coxiella is resistant to environmental conditions. Signup and view all the answers

How do Rickettsiae enter eukaryotic cells?

By an active process Signup and view all the answers

What is the general structure of Rickettsia's cell wall?

Made up of peptidoglycan (contains muramic acid and diaminopimelic acid) Signup and view all the answers

How do Chlamydiae differ from Rickettsia in terms of transmission and mode of invasion?

Chlamydiae are not transmitted by arthropods but invade the respiratory system, while Rickettsia are transmitted by arthropods. Signup and view all the answers

What are the main clinical manifestations of Chlamydiae infections in the human body?

Chlamydiae infections can cause trachoma, atypical pneumonia, and genitourinary infections by invading mucous membranes. Signup and view all the answers