Podcast
Questions and Answers
Match the type of lesion with its characteristic:
Match the type of lesion with its characteristic:
Primary Lesion = Originates on previously healthy skin Secondary Lesion = Evolution of primary lesion Chronic Wound = Impaired wound healing due to medical conditions Acute Wound = Enhanced immune response with pro-inflammatory mediators
Match the feature with the type of wound:
Match the feature with the type of wound:
Infection = Acute Wound Hypoxia = Chronic Wound Heightened immune response = Acute Wound Impaired tissue healing = Chronic Wound
Match the type of cell with its function in the healing process:
Match the type of cell with its function in the healing process:
Neutrophils = Migration to the injury site Mast cells = Promoting vasodilation to recruit more immune cells Macrophages = Differentiation from monocytes Epithelial cells = Proliferation in the healing process
Match the drug with its effect on wound healing:
Match the drug with its effect on wound healing:
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Match the condition with its effect on wound healing:
Match the condition with its effect on wound healing:
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Match the mediator with its function in the healing process:
Match the mediator with its function in the healing process:
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Match the characteristic with the type of lesion:
Match the characteristic with the type of lesion:
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Match the phase with the process in wound healing:
Match the phase with the process in wound healing:
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Study Notes
Physical Trauma and Lesions
- Characteristics of lesions: different from surrounding skin, usually benign and harmless but may progress to become malignant
Types of Lesions
- Primary Lesion: originates on previously healthy skin, associated with a direct cause
- Secondary Lesion: evolution of primary lesion, due to physical assault or treatment progression
Healing Process
- Immune response to injury involves: • Release of pro-inflammatory mediators • Monocytes differentiating • Migration of neutrophils and macrophages • Mast cells promoting vasodilation to recruit immune cells • Epithelial cells proliferating
Acute Wounds
- Features: • Infection, decreased angiogenesis, impaired tissue healing • Heightened immune response with: • Enhanced mast cells, TC, and TH cells • High levels of pro-inflammatory mediators (e.g., TNF, KGF) leading to poor tissue proliferation, vascularization, and tissue fibrosis
Chronic Wounds
- Impaired wound healing due to medical conditions: • Hypoxia, infection, smoking, alcohol, obesity, diabetes, myocardial infarction, immunocompromised patients, etc.
- Impaired wound healing due to drugs: • Glucocorticoids, NSAIDs, anti-platelets, anti-coagulants, cytotoxic agents (e.g., chemotherapy, immunosuppressants, immunomodulators), illicit substances, etc.
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Description
Learn about the characteristics of physical trauma, including primary and secondary lesions, and how the immune system responds to injury. Understand the differences between benign and malignant lesions and the progression of physical trauma.
