Phenytoin Kinetics Quiz

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Questions and Answers

What is the recommended administration of Phenytoin to reduce gastric irritation?

  • Before meals
  • With a glass of milk
  • After meals (correct)
  • On an empty stomach

How is Phenytoin affected by particle shape and size?

  • It is not affected by particle shape and size
  • It is only affected by particle size
  • It is affected by particle shape and size (correct)
  • It is only affected by particle shape

What is the drug of choice for Digitalis-Induced arrhythmia?

  • Phenytoin (correct)
  • Valproic acid
  • Levetiracetam
  • Carbamazepine

What adverse effect of Phenytoin can be irreversible and requires consultation with dentists, especially in children?

<p>Gingival hyperplasia (C)</p> Signup and view all the answers

In which condition can Phenytoin cause teratogenic effects resulting in Fetal Hydantoin Syndrome?

<p>First trimester of pregnancy (D)</p> Signup and view all the answers

What is the recommended route of administration for Phenytoin in the treatment of Status Epilepticus?

<p>Slow I.V. (B)</p> Signup and view all the answers

What is the primary site of metabolism of Phenytoin?

<p>Hepatic microsomal enzymes (D)</p> Signup and view all the answers

Which drug is an inducer of hepatic microsomal enzymes (HME) leading to the metabolism of other anti-epileptic drugs like barbiturates and carbamazepine?

<p>Phenytoin (D)</p> Signup and view all the answers

Which drug can displace Thyroxin and Tricyclic Anti-Depressants from plasma proteins?

<p>Phenytoin (D)</p> Signup and view all the answers

Which drug is a prodrug form of phenytoin and has the advantage of less vascular irritation and greater physical compatibility with IV and IM solutions?

<p>Fosphenytoin (B)</p> Signup and view all the answers

Which drug can inhibit the metabolism of phenytoin?

<p>Valproate (C)</p> Signup and view all the answers

Which drug can displace phenytoin from plasma proteins?

<p>Valproate (A)</p> Signup and view all the answers

Which deficiency can occur due to the metabolism of Vitamin K by phenytoin?

<p>Hypoprothrombinemia (A)</p> Signup and view all the answers

What deficiency can occur due to the metabolism of Folic Acid by phenytoin?

<p>Megaloblastic anemia (B)</p> Signup and view all the answers

What advantage does fosphenytoin have over phenytoin?

<p>Less vascular irritation (A)</p> Signup and view all the answers

What is the recommended administration of Phenytoin to reduce gastric irritation?

<p>After meals (A)</p> Signup and view all the answers

Which adverse effect of Phenytoin can be irreversible and requires consultation with dentists, especially in children?

<p>Gum (Gingival) Hyperplasia (A)</p> Signup and view all the answers

In which condition can Phenytoin cause teratogenic effects resulting in Fetal Hydantoin Syndrome?

<p>First trimester of pregnancy (C)</p> Signup and view all the answers

What is the primary site of metabolism of Vitamin K by phenytoin?

<p>Liver (B)</p> Signup and view all the answers

Which drug is a prodrug form of phenytoin and has the advantage of less vascular irritation and greater physical compatibility with IV and IM solutions?

<p>Fosphenytoin (A)</p> Signup and view all the answers

Which drug can displace Thyroxin and Tricyclic Anti-Depressants from plasma proteins?

<p>Phenytoin (A)</p> Signup and view all the answers

What deficiency can occur due to the metabolism of Folic Acid by phenytoin?

<p>Folate deficiency (C)</p> Signup and view all the answers

Which drug is an example of a hepatic microsomal enzyme (HME) inducer that can lead to the metabolism of other anti-epileptic drugs like barbiturates and carbamazepine?

<p>Phenytoin (C)</p> Signup and view all the answers

Which drug can displace Thyroxin and Tricyclic Anti-Depressants from plasma proteins?

<p>Phenytoin (B)</p> Signup and view all the answers

What adverse effect of Phenytoin can be irreversible and requires consultation with dentists, especially in children?

<p>Gingival hyperplasia (D)</p> Signup and view all the answers

In which condition can Phenytoin cause teratogenic effects resulting in Fetal Hydantoin Syndrome?

<p>Pregnancy (B)</p> Signup and view all the answers

What advantage does fosphenytoin have over phenytoin?

<p>Greater physical compatibility with IV and IM solutions (C)</p> Signup and view all the answers

Which drug can inhibit the metabolism of phenytoin?

<p>Valproate (B)</p> Signup and view all the answers

Which deficiency can occur due to the metabolism of Vitamin K by phenytoin?

<p>Hypoprothrombinemia (A)</p> Signup and view all the answers

What is the recommended route of administration for Phenytoin in the treatment of Status Epilepticus?

<p>Intravenous (D)</p> Signup and view all the answers

What is the primary site of metabolism of Phenytoin?

<p>Hepatic microsomal enzymes (C)</p> Signup and view all the answers

Which drug can inhibit the metabolism of phenytoin?

<p>Rifampicin (B)</p> Signup and view all the answers

What is the recommended route of administration for Phenytoin in the treatment of Status Epilepticus?

<p>Intravenous (B)</p> Signup and view all the answers

Which deficiency can occur due to the metabolism of Folic Acid by phenytoin?

<p>Vitamin B12 deficiency (C)</p> Signup and view all the answers

What advantage does fosphenytoin have over phenytoin?

<p>Rapid intravenous administration (C)</p> Signup and view all the answers

Which adverse effect of Phenytoin can be irreversible and requires consultation with dentists, especially in children?

<p>Gum (Gingival) Hyperplasia (C)</p> Signup and view all the answers

Which drug is an example of a hepatic microsomal enzyme (HME) inducer that can lead to the metabolism of other anti-epileptic drugs like barbiturates and carbamazepine?

<p>Phenobarbital (C)</p> Signup and view all the answers

Which drug is an example of a hepatic microsomal enzyme (HME) inducer that can lead to the metabolism of oral contraceptives?

<p>Phenobarbitone (A)</p> Signup and view all the answers

What deficiency can occur due to the metabolism of Folic Acid by phenytoin?

<p>Megaloblastic anemia (A)</p> Signup and view all the answers

Which drug can displace phenytoin from plasma proteins?

<p>Valproate (D)</p> Signup and view all the answers

What is the primary site of metabolism of Vitamin K by phenytoin?

<p>Liver (D)</p> Signup and view all the answers

What adverse effect of Phenytoin can be irreversible and requires consultation with dentists, especially in children?

<p>Gingival hyperplasia (B)</p> Signup and view all the answers

What advantage does fosphenytoin have over phenytoin?

<p>Less vascular irritation (D)</p> Signup and view all the answers

Which drug is a hepatic microsomal enzyme (HME) inhibitor that affects the metabolism of phenytoin?

<p>Valproate (D)</p> Signup and view all the answers

What is the prodrug form of phenytoin with the advantage of greater physical compatibility with IV and IM solutions to dilute it?

<p>Fosphenytoin (A)</p> Signup and view all the answers

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