45 Questions
What is the recommended administration of Phenytoin to reduce gastric irritation?
After meals
How is Phenytoin affected by particle shape and size?
It is affected by particle shape and size
What is the drug of choice for Digitalis-Induced arrhythmia?
Phenytoin
What adverse effect of Phenytoin can be irreversible and requires consultation with dentists, especially in children?
Gingival hyperplasia
In which condition can Phenytoin cause teratogenic effects resulting in Fetal Hydantoin Syndrome?
First trimester of pregnancy
What is the recommended route of administration for Phenytoin in the treatment of Status Epilepticus?
Slow I.V.
What is the primary site of metabolism of Phenytoin?
Hepatic microsomal enzymes
Which drug is an inducer of hepatic microsomal enzymes (HME) leading to the metabolism of other anti-epileptic drugs like barbiturates and carbamazepine?
Phenytoin
Which drug can displace Thyroxin and Tricyclic Anti-Depressants from plasma proteins?
Phenytoin
Which drug is a prodrug form of phenytoin and has the advantage of less vascular irritation and greater physical compatibility with IV and IM solutions?
Fosphenytoin
Which drug can inhibit the metabolism of phenytoin?
Valproate
Which drug can displace phenytoin from plasma proteins?
Valproate
Which deficiency can occur due to the metabolism of Vitamin K by phenytoin?
Hypoprothrombinemia
What deficiency can occur due to the metabolism of Folic Acid by phenytoin?
Megaloblastic anemia
What advantage does fosphenytoin have over phenytoin?
Less vascular irritation
What is the recommended administration of Phenytoin to reduce gastric irritation?
After meals
Which adverse effect of Phenytoin can be irreversible and requires consultation with dentists, especially in children?
Gum (Gingival) Hyperplasia
In which condition can Phenytoin cause teratogenic effects resulting in Fetal Hydantoin Syndrome?
First trimester of pregnancy
What is the primary site of metabolism of Vitamin K by phenytoin?
Liver
Which drug is a prodrug form of phenytoin and has the advantage of less vascular irritation and greater physical compatibility with IV and IM solutions?
Fosphenytoin
Which drug can displace Thyroxin and Tricyclic Anti-Depressants from plasma proteins?
Phenytoin
What deficiency can occur due to the metabolism of Folic Acid by phenytoin?
Folate deficiency
Which drug is an example of a hepatic microsomal enzyme (HME) inducer that can lead to the metabolism of other anti-epileptic drugs like barbiturates and carbamazepine?
Phenytoin
Which drug can displace Thyroxin and Tricyclic Anti-Depressants from plasma proteins?
Phenytoin
What adverse effect of Phenytoin can be irreversible and requires consultation with dentists, especially in children?
Gingival hyperplasia
In which condition can Phenytoin cause teratogenic effects resulting in Fetal Hydantoin Syndrome?
Pregnancy
What advantage does fosphenytoin have over phenytoin?
Greater physical compatibility with IV and IM solutions
Which drug can inhibit the metabolism of phenytoin?
Valproate
Which deficiency can occur due to the metabolism of Vitamin K by phenytoin?
Hypoprothrombinemia
What is the recommended route of administration for Phenytoin in the treatment of Status Epilepticus?
Intravenous
What is the primary site of metabolism of Phenytoin?
Hepatic microsomal enzymes
Which drug can inhibit the metabolism of phenytoin?
Rifampicin
What is the recommended route of administration for Phenytoin in the treatment of Status Epilepticus?
Intravenous
Which deficiency can occur due to the metabolism of Folic Acid by phenytoin?
Vitamin B12 deficiency
What advantage does fosphenytoin have over phenytoin?
Rapid intravenous administration
Which adverse effect of Phenytoin can be irreversible and requires consultation with dentists, especially in children?
Gum (Gingival) Hyperplasia
Which drug is an example of a hepatic microsomal enzyme (HME) inducer that can lead to the metabolism of other anti-epileptic drugs like barbiturates and carbamazepine?
Phenobarbital
Which drug is an example of a hepatic microsomal enzyme (HME) inducer that can lead to the metabolism of oral contraceptives?
Phenobarbitone
What deficiency can occur due to the metabolism of Folic Acid by phenytoin?
Megaloblastic anemia
Which drug can displace phenytoin from plasma proteins?
Valproate
What is the primary site of metabolism of Vitamin K by phenytoin?
Liver
What adverse effect of Phenytoin can be irreversible and requires consultation with dentists, especially in children?
Gingival hyperplasia
What advantage does fosphenytoin have over phenytoin?
Less vascular irritation
Which drug is a hepatic microsomal enzyme (HME) inhibitor that affects the metabolism of phenytoin?
Valproate
What is the prodrug form of phenytoin with the advantage of greater physical compatibility with IV and IM solutions to dilute it?
Fosphenytoin
Test your knowledge of the kinetics of the anti-epilepsy drug Phenytoin (Diphenyl-Hydantoin, Epanutin) with this quiz. Explore its absorption, distribution, metabolism, and more.
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