Phenytoin Kinetics Quiz
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Questions and Answers

What is the recommended administration of Phenytoin to reduce gastric irritation?

  • Before meals
  • With a glass of milk
  • After meals (correct)
  • On an empty stomach

    • How is Phenytoin affected by particle shape and size?

  • It is not affected by particle shape and size
  • It is only affected by particle size
  • It is affected by particle shape and size (correct)
  • It is only affected by particle shape

    • What is the drug of choice for Digitalis-Induced arrhythmia?

  • Phenytoin (correct)
  • Valproic acid
  • Levetiracetam
  • Carbamazepine

    • What adverse effect of Phenytoin can be irreversible and requires consultation with dentists, especially in children?

    <p>Gingival hyperplasia</p> Signup and view all the answers

    In which condition can Phenytoin cause teratogenic effects resulting in Fetal Hydantoin Syndrome?

    <p>First trimester of pregnancy</p> Signup and view all the answers

    What is the recommended route of administration for Phenytoin in the treatment of Status Epilepticus?

    <p>Slow I.V.</p> Signup and view all the answers

    What is the primary site of metabolism of Phenytoin?

    <p>Hepatic microsomal enzymes</p> Signup and view all the answers

    Which drug is an inducer of hepatic microsomal enzymes (HME) leading to the metabolism of other anti-epileptic drugs like barbiturates and carbamazepine?

    <p>Phenytoin</p> Signup and view all the answers

    Which drug can displace Thyroxin and Tricyclic Anti-Depressants from plasma proteins?

    <p>Phenytoin</p> Signup and view all the answers

    Which drug is a prodrug form of phenytoin and has the advantage of less vascular irritation and greater physical compatibility with IV and IM solutions?

    <p>Fosphenytoin</p> Signup and view all the answers

    Which drug can inhibit the metabolism of phenytoin?

    <p>Valproate</p> Signup and view all the answers

    Which drug can displace phenytoin from plasma proteins?

    <p>Valproate</p> Signup and view all the answers

    Which deficiency can occur due to the metabolism of Vitamin K by phenytoin?

    <p>Hypoprothrombinemia</p> Signup and view all the answers

    What deficiency can occur due to the metabolism of Folic Acid by phenytoin?

    <p>Megaloblastic anemia</p> Signup and view all the answers

    What advantage does fosphenytoin have over phenytoin?

    <p>Less vascular irritation</p> Signup and view all the answers

    What is the recommended administration of Phenytoin to reduce gastric irritation?

    <p>After meals</p> Signup and view all the answers

    Which adverse effect of Phenytoin can be irreversible and requires consultation with dentists, especially in children?

    <p>Gum (Gingival) Hyperplasia</p> Signup and view all the answers

    In which condition can Phenytoin cause teratogenic effects resulting in Fetal Hydantoin Syndrome?

    <p>First trimester of pregnancy</p> Signup and view all the answers

    What is the primary site of metabolism of Vitamin K by phenytoin?

    <p>Liver</p> Signup and view all the answers

    Which drug is a prodrug form of phenytoin and has the advantage of less vascular irritation and greater physical compatibility with IV and IM solutions?

    <p>Fosphenytoin</p> Signup and view all the answers

    Which drug can displace Thyroxin and Tricyclic Anti-Depressants from plasma proteins?

    <p>Phenytoin</p> Signup and view all the answers

    What deficiency can occur due to the metabolism of Folic Acid by phenytoin?

    <p>Folate deficiency</p> Signup and view all the answers

    Which drug is an example of a hepatic microsomal enzyme (HME) inducer that can lead to the metabolism of other anti-epileptic drugs like barbiturates and carbamazepine?

    <p>Phenytoin</p> Signup and view all the answers

    Which drug can displace Thyroxin and Tricyclic Anti-Depressants from plasma proteins?

    <p>Phenytoin</p> Signup and view all the answers

    What adverse effect of Phenytoin can be irreversible and requires consultation with dentists, especially in children?

    <p>Gingival hyperplasia</p> Signup and view all the answers

    In which condition can Phenytoin cause teratogenic effects resulting in Fetal Hydantoin Syndrome?

    <p>Pregnancy</p> Signup and view all the answers

    What advantage does fosphenytoin have over phenytoin?

    <p>Greater physical compatibility with IV and IM solutions</p> Signup and view all the answers

    Which drug can inhibit the metabolism of phenytoin?

    <p>Valproate</p> Signup and view all the answers

    Which deficiency can occur due to the metabolism of Vitamin K by phenytoin?

    <p>Hypoprothrombinemia</p> Signup and view all the answers

    What is the recommended route of administration for Phenytoin in the treatment of Status Epilepticus?

    <p>Intravenous</p> Signup and view all the answers

    What is the primary site of metabolism of Phenytoin?

    <p>Hepatic microsomal enzymes</p> Signup and view all the answers

    Which drug can inhibit the metabolism of phenytoin?

    <p>Rifampicin</p> Signup and view all the answers

    What is the recommended route of administration for Phenytoin in the treatment of Status Epilepticus?

    <p>Intravenous</p> Signup and view all the answers

    Which deficiency can occur due to the metabolism of Folic Acid by phenytoin?

    <p>Vitamin B12 deficiency</p> Signup and view all the answers

    What advantage does fosphenytoin have over phenytoin?

    <p>Rapid intravenous administration</p> Signup and view all the answers

    Which adverse effect of Phenytoin can be irreversible and requires consultation with dentists, especially in children?

    <p>Gum (Gingival) Hyperplasia</p> Signup and view all the answers

    Which drug is an example of a hepatic microsomal enzyme (HME) inducer that can lead to the metabolism of other anti-epileptic drugs like barbiturates and carbamazepine?

    <p>Phenobarbital</p> Signup and view all the answers

    Which drug is an example of a hepatic microsomal enzyme (HME) inducer that can lead to the metabolism of oral contraceptives?

    <p>Phenobarbitone</p> Signup and view all the answers

    What deficiency can occur due to the metabolism of Folic Acid by phenytoin?

    <p>Megaloblastic anemia</p> Signup and view all the answers

    Which drug can displace phenytoin from plasma proteins?

    <p>Valproate</p> Signup and view all the answers

    What is the primary site of metabolism of Vitamin K by phenytoin?

    <p>Liver</p> Signup and view all the answers

    What adverse effect of Phenytoin can be irreversible and requires consultation with dentists, especially in children?

    <p>Gingival hyperplasia</p> Signup and view all the answers

    What advantage does fosphenytoin have over phenytoin?

    <p>Less vascular irritation</p> Signup and view all the answers

    Which drug is a hepatic microsomal enzyme (HME) inhibitor that affects the metabolism of phenytoin?

    <p>Valproate</p> Signup and view all the answers

    What is the prodrug form of phenytoin with the advantage of greater physical compatibility with IV and IM solutions to dilute it?

    <p>Fosphenytoin</p> Signup and view all the answers

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