Podcast
Questions and Answers
What is the usual initial dose of phenytoin for acute indications?
What is the usual initial dose of phenytoin for acute indications?
- 100-200 mg/day PO
- 300-600 mg/day PO
- 200-500 mg/day PO
- 150-300 mg/day PO (correct)
What is the therapeutic range of total phenytoin in blood samples?
What is the therapeutic range of total phenytoin in blood samples?
- 10-20 mg/L (correct)
- 30-40 mg/L
- 20-30 mg/L
- 5-10 mg/L
What is a common chronic adverse effect of phenytoin, occurring in 20% of patients?
What is a common chronic adverse effect of phenytoin, occurring in 20% of patients?
- Hirsutism
- Folate deficiency
- Coarsening of facial features
- Gingival hyperplasia (correct)
At what phenytoin level can drug-induced seizures occur?
At what phenytoin level can drug-induced seizures occur?
What is the therapeutic range of free phenytoin concentration in saliva samples?
What is the therapeutic range of free phenytoin concentration in saliva samples?
What is the recommended action if a patient develops symptoms such as fever, rash, mouth ulcers, bruising, or bleeding while taking phenytoin?
What is the recommended action if a patient develops symptoms such as fever, rash, mouth ulcers, bruising, or bleeding while taking phenytoin?
Why is it important to maintain a patient on a specific manufacturer's product when treating epilepsy with phenytoin?
Why is it important to maintain a patient on a specific manufacturer's product when treating epilepsy with phenytoin?
What is the approximate therapeutic equivalent of 100 mg of phenytoin sodium?
What is the approximate therapeutic equivalent of 100 mg of phenytoin sodium?
What is the recommended timing for taking a phenytoin level after initiating therapy?
What is the recommended timing for taking a phenytoin level after initiating therapy?
What is the indication for the use of intravenous phenytoin formulation?
What is the indication for the use of intravenous phenytoin formulation?
What is the percentage of plasma protein binding of phenytoin?
What is the percentage of plasma protein binding of phenytoin?
What is the effect of a decrease in protein binding on phenytoin's therapeutic activity?
What is the effect of a decrease in protein binding on phenytoin's therapeutic activity?
What is the formula for calculating Cp adjusted, the adjusted phenytoin concentration?
What is the formula for calculating Cp adjusted, the adjusted phenytoin concentration?
What is the quoted half-life of phenytoin?
What is the quoted half-life of phenytoin?
Why is it necessary to monitor plasma-phenytoin concentration?
Why is it necessary to monitor plasma-phenytoin concentration?
