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Questions and Answers
Which dosage form of phenytoin has a salt factor of 0.92?
Which dosage form of phenytoin has a salt factor of 0.92?
- Capsule (correct)
- Injection
- Suspension
- Chewable tablets
What is the concentration range for minor CNS depression caused by phenytoin?
What is the concentration range for minor CNS depression caused by phenytoin?
- 15-20 ug/mL (correct)
- 40-50 ug/mL
- 20-30 ug/mL
- 30-40 ug/mL
At what concentration range does ataxia, slurred speech, and incoordination occur as a result of phenytoin toxicity?
At what concentration range does ataxia, slurred speech, and incoordination occur as a result of phenytoin toxicity?
- 50-60 ug/mL
- 30-40 ug/mL (correct)
- 20-30 ug/mL
- 40-50 ug/mL
What concentration range is associated with mental status change, severe confusion and lethargy, and coma due to phenytoin toxicity?
What concentration range is associated with mental status change, severe confusion and lethargy, and coma due to phenytoin toxicity?
Which dosing method should take into consideration the salt factor of phenytoin?
Which dosing method should take into consideration the salt factor of phenytoin?
Phenytoin is primarily used for the treatment of which type of seizures?
Phenytoin is primarily used for the treatment of which type of seizures?
What is the mechanism of action of phenytoin?
What is the mechanism of action of phenytoin?
What is the main difference between phenytoin and fosphenytoin formulations?
What is the main difference between phenytoin and fosphenytoin formulations?
What is the equation for the pharmacokinetics of phenytoin?
What is the equation for the pharmacokinetics of phenytoin?
What is the main difference between Vmax and Km?
What is the main difference between Vmax and Km?
Which equation is used to calculate body mass index (BMI)?
Which equation is used to calculate body mass index (BMI)?
Which of the following BMI ranges corresponds to normal weight?
Which of the following BMI ranges corresponds to normal weight?
What is the equation for calculating body surface area (BSA)?
What is the equation for calculating body surface area (BSA)?
When is a patient considered morbidly obese based on BMI?
When is a patient considered morbidly obese based on BMI?
What is the equation for calculating ideal body weight (IBW) for males?
What is the equation for calculating ideal body weight (IBW) for males?
What is the equation for calculating adjusted body weight (ABW) using a correction factor of 0.4?
What is the equation for calculating adjusted body weight (ABW) using a correction factor of 0.4?
What is the purpose of adjusted body weight (ABW) calculations?
What is the purpose of adjusted body weight (ABW) calculations?
Which equation represents the calculation for adjusted body weight (ABW)?
Which equation represents the calculation for adjusted body weight (ABW)?
What is the impact of obesity on hepatic drug clearance?
What is the impact of obesity on hepatic drug clearance?
Which type of drugs may show an increase, decrease, or no change in plasma protein binding in obesity?
Which type of drugs may show an increase, decrease, or no change in plasma protein binding in obesity?
What is the equation for renal clearance?
What is the equation for renal clearance?
What are the physiological changes in obesity that affect drug distribution?
What are the physiological changes in obesity that affect drug distribution?
What is the equation for predicting changes in volume of distribution for hydrophilic (polar) compounds in obese individuals?
What is the equation for predicting changes in volume of distribution for hydrophilic (polar) compounds in obese individuals?
What is the impact of obesity on the half-life of phenytoin in obese patients compared to normal weight patients?
What is the impact of obesity on the half-life of phenytoin in obese patients compared to normal weight patients?
What is the impact of obesity on the volume of distribution of lithium in obese individuals compared to non-obese individuals?
What is the impact of obesity on the volume of distribution of lithium in obese individuals compared to non-obese individuals?
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