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Questions and Answers
What is the therapeutic class of Phenylephrine (Neo-Synephrine)?
What is the therapeutic class of Phenylephrine (Neo-Synephrine)?
What is the pharmacologic class of Phenylephrine (Neo-Synephrine)?
What is the pharmacologic class of Phenylephrine (Neo-Synephrine)?
Adrenergic drug (sympathomimetic)
How does Phenylephrine reduce nasal congestion?
How does Phenylephrine reduce nasal congestion?
By constricting the small vessels in the nasal mucosa
What effect does Phenylephrine have when applied topically to the eye?
What effect does Phenylephrine have when applied topically to the eye?
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What is one advantage of Phenylephrine over epinephrine in treating acute hypotension?
What is one advantage of Phenylephrine over epinephrine in treating acute hypotension?
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Which of the following are common side effects of Phenylephrine?
Which of the following are common side effects of Phenylephrine?
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Phenylephrine should be used cautiously in patients with heart disease.
Phenylephrine should be used cautiously in patients with heart disease.
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What should be used to treat an overdose of Phenylephrine?
What should be used to treat an overdose of Phenylephrine?
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What is the intended therapeutic response of Phenylephrine?
What is the intended therapeutic response of Phenylephrine?
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What is a contraindication for using Phenylephrine?
What is a contraindication for using Phenylephrine?
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Study Notes
Phenylephrine (Neo-Synephrine) Overview
- Classified as a nasal decongestant, mydriatic agent, and antihypotensive.
- Functions as an adrenergic drug that mimics sympathetic nerve activity.
Administration Routes
- Intranasal: Reduces nasal congestion by constricting small vessels in the nasal mucosa when applied as sprays or drops.
- Topical: Used in ophthalmic examinations to dilate pupils without significant cycloplegia.
- Parenteral: Effective in reversing acute hypotension from spinal anesthesia or vascular shock. Produces fewer cardiac side effects due to lack of beta-adrenergic activity.
Side Effects
- Common side effects include anxiety, restlessness, and tremor due to central nervous system stimulation.
- Less frequent effects with topical and intranasal use; prolonged intranasal usage may induce mucosal burning and rebound congestion.
Administration Alerts
- Parenteral use can cause tissue injury from extravasation.
- Ophthalmic drops may damage soft contact lenses.
- Classified as Pregnancy Category C.
Adverse Effects
- Topical/intranasal: Rare side effects, but prolonged use can lead to burning and narrow-angle glaucoma scenarios.
- Parenteral use can increase blood pressure and cause ventricular tachycardia, especially in patients with cardiovascular issues.
Contraindications
- Not recommended for patients with acute pancreatitis, heart disease, hepatitis, or narrow-angle glaucoma.
Overdose Management
- Managed with phentolamine (Regitine) to decrease blood pressure.
Expected Actions & Uses
- Acts as a selective alpha-adrenergic agonist with various formulations (intranasal, ophthalmic, IM, SQ, IV).
- Its actions are extensions of sympathetic stimulation, targeting similar responses as anticholinergic agents.
Desired Therapeutic Response
- Directly or indirectly stimulates the sympathetic nervous system, leading to various physiological responses associated with this system.
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Description
Test your knowledge on Phenylephrine (Neo-Synephrine) with these flashcards. Learn about its therapeutic and pharmacologic classifications, as well as administration methods. Perfect for students studying pharmacology or healthcare practitioners.
