Podcast
Questions and Answers
What is the primary function of Phase I metabolism in drug metabolism?
What is the primary function of Phase I metabolism in drug metabolism?
- To decrease renal elimination of drugs
- To attach substituent groups to the drug
- To introduce groups that can undergo Phase II reactions (correct)
- To increase lipid solubility of drugs
What is the most common Phase I reaction catalyzed by CYP450 enzymes?
What is the most common Phase I reaction catalyzed by CYP450 enzymes?
- Reduction
- Oxidation (correct)
- Glucuronidation
- Hydrolysis
Which of the following enzymes is NOT a Phase I metabolic enzyme?
Which of the following enzymes is NOT a Phase I metabolic enzyme?
- UDP-glucuronosyltransferase (UGT's) (correct)
- Azo reductase
- CYP450
- Aldehyde dehydrogenase
What is the purpose of the catalytic cycle of CYP450 enzymes?
What is the purpose of the catalytic cycle of CYP450 enzymes?
Which of the following is a consequence of inhibition of the CYP450 system?
Which of the following is a consequence of inhibition of the CYP450 system?
What is the main difference between Phase I and Phase II metabolism?
What is the main difference between Phase I and Phase II metabolism?
What is the primary function of flavin monooxygenase in Phase I metabolism?
What is the primary function of flavin monooxygenase in Phase I metabolism?
Which of the following is an example of a Phase I oxidation reaction?
Which of the following is an example of a Phase I oxidation reaction?
What is the classification of CYP3A4 enzyme?
What is the classification of CYP3A4 enzyme?
What is the purpose of sulphonation in Phase II metabolism?
What is the purpose of sulphonation in Phase II metabolism?
What is the primary purpose of drug metabolism in the body?
What is the primary purpose of drug metabolism in the body?
What is the main site of drug metabolism in the body?
What is the main site of drug metabolism in the body?
What is the result of Phase I metabolic reactions?
What is the result of Phase I metabolic reactions?
What is the consequence of converting an active drug into an inactive metabolite?
What is the consequence of converting an active drug into an inactive metabolite?
Which of the following is an example of an active drug being converted into an active metabolite?
Which of the following is an example of an active drug being converted into an active metabolite?
What is the role of enzymes in drug metabolism?
What is the role of enzymes in drug metabolism?
What is the result of coadministering two drugs that are metabolized by the same enzyme?
What is the result of coadministering two drugs that are metabolized by the same enzyme?
What is the effect of CYP450 inducers on drug metabolism?
What is the effect of CYP450 inducers on drug metabolism?
Which of the following is an example of a CYP450 inhibitor?
Which of the following is an example of a CYP450 inhibitor?
What is the consequence of drug-drug interactions involving synergism?
What is the consequence of drug-drug interactions involving synergism?
What is the purpose of identifying the CYP that metabolizes a drug?
What is the purpose of identifying the CYP that metabolizes a drug?
What is the effect of CYP450 inhibitors on the therapeutic concentration of drugs?
What is the effect of CYP450 inhibitors on the therapeutic concentration of drugs?
