Stability of Medicines

Play an AI-generated podcast conversation about this lesson

What is a potential physicochemical effect that can impact the solubility of drugs like diazepam?

Leaching of phthalates

Solvent composition in drug formulations (correct)

Addition of chelating agents

Exclusion of oxygen during packaging

How can the stability of basic drugs be enhanced according to the text?

Adding antioxidants like ascorbic acid

Increasing exposure to light transmission

Diluting the drug to a certain ratio (correct)

Mixing with a higher concentration of propylene glycol

What type of drug formulation issue arises when preparing a diazepam injection with specific solvent compositions?

Precipitation depending on concentration (correct)

Migration of phthalates

Leaching of inorganic radicals

Formation of crystalline forms

What is a common method mentioned in the text for minimizing oxidation in pharmaceutical products?

Using water-soluble sacrificial agents Signup and view all the answers

What area of pre-formulation is often overlooked, as mentioned in the text?

Drug-excipent interaction Signup and view all the answers

What can be used to remove metal ions from pharmaceutical products?

Chelating agents like EDTA and citric acid Signup and view all the answers

How can the stability of basic drugs be increased in acidic conditions according to the text?

Diluting the drug to a certain ratio Signup and view all the answers

What is the purpose of using Butylated hydroxytoluene (BHT) in medicines?

To improve the physical stability of the medicine Signup and view all the answers

How does oxidation impact fatty acids?

It forms hydroperoxides and ketones/aldehydes Signup and view all the answers

What is a common consequence of the oxidation of adrenaline?

Formation of Adrenochrome Signup and view all the answers

Why is captopril available only as a solid dosage form?

To ensure a proportion of the tablet is required for therapeutic effect Signup and view all the answers

What do short shelf lives of extemporaneous aqueous preparations imply?

Reduced microbial stability Signup and view all the answers

How does understanding medicine stability help in patient treatment?

By maintaining therapeutic efficacy Signup and view all the answers

Which aspect of drug degradation has been the focus in the provided content?

Physical aspects Signup and view all the answers

What factor can lead to the loss of protection against microbiological spoilage?

Hydrolysis of antimicrobial agent Signup and view all the answers

Which factor may lead to a change in bioavailability of medicines?

Loss of active through evaporation Signup and view all the answers

What characteristic does polymorphic form I have?

Lowest dissolution rate Signup and view all the answers

Which medicine may convert to an amorphous form with higher dissolution rate under mechanical stress?

Digoxin Signup and view all the answers

What is the consequence of large particles in suspensions according to Stoke's Law?

They settle too quickly Signup and view all the answers

Which type of emulsion is thermodynamically unstable?

Water in oil Signup and view all the answers

'Creaming' is most likely to occur in which type of emulsion?

Oil in water emulsions with high viscosity Signup and view all the answers

What does 'stability' refer to in the context of medicines?

The ability to maintain original characteristics during manufacture, transport, storage, and use Signup and view all the answers

Which of the following is NOT a role of a pharmacist in relation to stability of medicines?

Ensuring long-term stability by using crystalline forms Signup and view all the answers

What does the term 'bioavailability changes' refer to in the context of medicines?

Changes in the availability of the active ingredient for absorption into the body Signup and view all the answers

Which aspect is NOT included in a pharmacist's role in maintenance of stability?

Medicine preparation through crystalline forms Signup and view all the answers

What are pharmacists required to understand regarding the clinical implications of loss of stability?

Comprehension of clinical implications of stability loss Signup and view all the answers

How does the design of stable medicines contribute to their long-term effectiveness?

By enhancing stability through suitable storage methods Signup and view all the answers

Which factor is essential for assessing the long-term stability of medicines?

Understanding causes of instability Signup and view all the answers

'Maintenance of stability' includes which important activity related to medicine use?

Medicine Compliance Aids Signup and view all the answers

What does 'product stability' encompass as it relates to medicines?

The ability to maintain original characteristics throughout all stages, from manufacture to use. Signup and view all the answers

What are the implications of drug degradation that pharmacists should understand?

Therapeutic effect, side effects, interactions Signup and view all the answers

Explain the importance of understanding the physical stability of medicines.

To prevent issues like creaming in emulsions Signup and view all the answers

How does oxidation impact fatty acids?

Forms hydroperoxides, ketones, and/or aldehydes Signup and view all the answers

What is the role of captopril in pharmaceutical use?

ACE inhibitor for hypertension Signup and view all the answers

Why are extemporaneous aqueous preparations known for short shelf lives?

They degrade quickly Signup and view all the answers

Stability of Medicines

Podcast Beta

Questions and Answers

What is a potential physicochemical effect that can impact the solubility of drugs like diazepam?

How can the stability of basic drugs be enhanced according to the text?

What type of drug formulation issue arises when preparing a diazepam injection with specific solvent compositions?

What is a common method mentioned in the text for minimizing oxidation in pharmaceutical products?

What area of pre-formulation is often overlooked, as mentioned in the text?

What can be used to remove metal ions from pharmaceutical products?

How can the stability of basic drugs be increased in acidic conditions according to the text?

What is the purpose of using Butylated hydroxytoluene (BHT) in medicines?

How does oxidation impact fatty acids?

What is a common consequence of the oxidation of adrenaline?

Why is captopril available only as a solid dosage form?

What do short shelf lives of extemporaneous aqueous preparations imply?

How does understanding medicine stability help in patient treatment?

Which aspect of drug degradation has been the focus in the provided content?

What factor can lead to the loss of protection against microbiological spoilage?

Which factor may lead to a change in bioavailability of medicines?

What characteristic does polymorphic form I have?

Which medicine may convert to an amorphous form with higher dissolution rate under mechanical stress?

What is the consequence of large particles in suspensions according to Stoke's Law?

Which type of emulsion is thermodynamically unstable?

'Creaming' is most likely to occur in which type of emulsion?

What does 'stability' refer to in the context of medicines?

Which of the following is NOT a role of a pharmacist in relation to stability of medicines?

What does the term 'bioavailability changes' refer to in the context of medicines?

Which aspect is NOT included in a pharmacist's role in maintenance of stability?

What are pharmacists required to understand regarding the clinical implications of loss of stability?

How does the design of stable medicines contribute to their long-term effectiveness?

Which factor is essential for assessing the long-term stability of medicines?

'Maintenance of stability' includes which important activity related to medicine use?

What does 'product stability' encompass as it relates to medicines?

What are the implications of drug degradation that pharmacists should understand?

Explain the importance of understanding the physical stability of medicines.

How does oxidation impact fatty acids?

What is the role of captopril in pharmaceutical use?

Why are extemporaneous aqueous preparations known for short shelf lives?

More Quizzes Like This

Pharmaceutics and Drug Stability Kinetics Quiz

Sterility Requirements for CSPs

مدى الصلاحية الدوائية

Control de Calidad: Estabilidades de Medicamentos