Pharmacology Week 11: Estrogen and Progesterone

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Questions and Answers

What is the mechanism of action of progestin in inhibiting the LH surge in the pituitary?

  • By binding to estrogen receptors in the liver
  • By atrophying the endometrium and thickening the cervical mucus (correct)
  • By stimulating the production of blood clotting factors
  • By inhibiting the release of FSH from the pituitary

Which of the following is a physiological effect of estrogen-based contraceptives?

  • Weight loss and improved acne
  • Increased serotonin levels and reduced risk of depression
  • Decreased fluid retention and increased HDL
  • Increased hepatic protein production and increased risk of DVT (correct)

What is the difference between the mechanism of action of estrogen and progestin in contraceptives?

  • Estrogen potentiates the action of progestin agents, while progestin inhibits the LH surge (correct)
  • Estrogen increases serotonin levels, while progestin decreases it
  • Estrogen stabilizes the endometrium, while progestin atrophies it
  • Estrogen suppresses FSH secretion, while progestin stimulates LH surge

Which generation of progestin-based contraceptives includes desogestrel and norgestrel?

<p>Second generation (C)</p> Signup and view all the answers

What is the benefit of estrogen-based contraceptives in terms of bone health?

<p>Decreased risk of osteoporosis (A)</p> Signup and view all the answers

What is the primary mechanism of action of Follicle Stimulating Hormone in females?

<p>Inducing LH receptor expression and follicle maturation (A)</p> Signup and view all the answers

Which of the following estrogens is synthesized by the placenta during pregnancy?

<p>Estriol (B)</p> Signup and view all the answers

What is the result of chronic release of GnRH in the Hypothalamic-Pituitary Gonadal Axis?

<p>Down regulation of FSH and LH secretion (B)</p> Signup and view all the answers

Which of the following hormones stimulates Sertoli cells to promote sperm maturation in males?

<p>Follicle Stimulating Hormone (FSH) (D)</p> Signup and view all the answers

What is the primary mechanism of action of Selective Estrogen Receptor Modulators (SERMs) in the treatment of postmenopausal symptoms?

<p>Binding to estrogen receptors in the brain to alleviate hot flashes (A)</p> Signup and view all the answers

What is the parent compound for all steroid hormones, including estrogens and androgens?

<p>Cholesterol (D)</p> Signup and view all the answers

Which of the following is a physiological effect of hormonal contraceptives?

<p>Regulation of menstrual cycles (B)</p> Signup and view all the answers

What is the primary function of gonads in the production of sex hormones?

<p>To produce sex hormones for conception and embryonic maturation (C)</p> Signup and view all the answers

What is the mechanism of action of Hormone Replacement Therapy (HRT) in the treatment of postmenopausal symptoms?

<p>Replacing estrogen and progesterone to alleviate symptoms (C)</p> Signup and view all the answers

Which of the following is an example of a progestin-based contraceptive?

<p>Emergency contraception (A)</p> Signup and view all the answers

What is the primary effect of estrogen on blood lipid profiles?

<p>Increases triglycerides, HDL, and decreases cholesterol synthesis (C)</p> Signup and view all the answers

What is the primary mechanism by which Ethinyl Estradiol (EE) increases its bioavailability when taken orally?

<p>Addition of a triple bond to estradiol (A)</p> Signup and view all the answers

Which of the following physiological effects of estrogen is NOT related to its role in cardiovascular health?

<p>Increases bile acid secretion (B)</p> Signup and view all the answers

What is the effect of estrogen on sodium levels in the body?

<p>Increases sodium retention (B)</p> Signup and view all the answers

What is the primary role of estrogen in the development of the female reproductive system?

<p>Development of the endometrial lining (C)</p> Signup and view all the answers

What is the primary indication for emergency contraception?

<p>Failure of hormonal contraception or exposure to teratogen (A)</p> Signup and view all the answers

What is a self-administered hormonal contraceptive (SAHC) example?

<p>NuvaRing (D)</p> Signup and view all the answers

What is the purpose of the USMEC screening tool?

<p>To identify patient risk factors for SAHC (A)</p> Signup and view all the answers

What is a requirement for pharmacist training in California?

<p>1 hour of board-approved continuing education program or equivalent training program (D)</p> Signup and view all the answers

What is a common side effect of hormonal emergency contraception?

<p>Bleeding between periods (C)</p> Signup and view all the answers

What is the mechanism of action of Ulipristal as an emergency contraceptive?

<p>Selective progesterone receptor modulator to delay or prevent ovulation (D)</p> Signup and view all the answers

Which of the following is a potential side effect of Ulipristal emergency contraception?

<p>Menstrual irregularities (A)</p> Signup and view all the answers

What is the recommended timing for initiating long-term hormonal birth control after taking Ulipristal?

<p>Wait 5 days after taking Ulipristal (B)</p> Signup and view all the answers

What is the effectiveness of Levonorgestrel (Plan B One-Step) as an emergency contraceptive?

<p>89% effective (A)</p> Signup and view all the answers

What is the weight consideration for Ulipristal emergency contraception?

<p>No FDA approved weight, but decreased effectiveness &gt;165 lbs (D)</p> Signup and view all the answers

Which side effect is associated with progestin-based contraceptives?

<p>Breakthrough bleeding late cycle (A)</p> Signup and view all the answers

What type of oral pill administration has the same amount of hormones in each active pill?

<p>Monophasic (B)</p> Signup and view all the answers

When should a woman start taking hormonal contraceptives if she has just had unprotected sex and wants to minimize the risk of pregnancy?

<p>Anytime start or quick start (C)</p> Signup and view all the answers

Who should not take combined hormonal contraceptives?

<p>Women 35 or older who smoke cigarettes (B)</p> Signup and view all the answers

What is the role of a pharmacist in providing hormonal contraceptives?

<p>Furnish patients with medications (A)</p> Signup and view all the answers

What is the significance of the 'Sunday start' in hormonal contraceptives?

<p>Cycle begins on Sunday always (C)</p> Signup and view all the answers

What is an example of an estrogen-associated side effect?

<p>Breast tenderness (C)</p> Signup and view all the answers

What is the significance of the 'First day of bleeding start' in hormonal contraceptives?

<p>Protection immediate (A)</p> Signup and view all the answers

What is a contraindication for combined hormonal contraceptives?

<p>History of blood clots or stroke (B)</p> Signup and view all the answers

What type of hormonal contraceptive is recommended for women who experience irregular periods?

<p>Progestin-only pill (B)</p> Signup and view all the answers

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