Pharmacology Subject Wise Test
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Questions and Answers

Which medication is most likely started for a female patient presenting with symptoms of hyperthyroidism?

  • Lorazepam
  • Methimazole (correct)
  • Propranolol
  • Amiodarone
  • What is the mechanism of action of Sulfonylureas?

  • Increase PPAR-γ activity
  • SGLT-2 inhibitors
  • Inhibit α-glucosidase activity
  • Inhibit ATP sensitive K+ channels (correct)
  • What is the most likely diagnosis for a patient on haloperidol who presents with eye movement issues but normal neurological examination?

  • Acute dystonia (correct)
  • Seizure
  • Akathisia
  • Tardive dyskinesia
  • Which antiarrhythmic drug is contraindicated in patients with interstitial lung disease?

    <p>Amiodarone</p> Signup and view all the answers

    Which monoclonal antibody is used for the treatment of Alzheimer's disease?

    <p>Adacanumab</p> Signup and view all the answers

    Which medication should be avoided in a pregnant woman with hypertension?

    <p>Perindopril</p> Signup and view all the answers

    In a patient with suspected exercise-induced asthma and elevated IOP, which medication should be avoided?

    <p>Acetazolamide</p> Signup and view all the answers

    What is the safest anti-epileptic medication to use during pregnancy?

    <p>Levetiracetam</p> Signup and view all the answers

    Which statement regarding 1st order kinetics is true?

    <p>Constant fraction of drug is eliminated per unit time</p> Signup and view all the answers

    Which of the following represents the rate of absorption on a concentration-time graph?

    <p>Tmax</p> Signup and view all the answers

    Which drug is not typically used as a transdermal patch?

    <p>Promethazine</p> Signup and view all the answers

    Sumatriptan acts as an agonist of which receptor?

    <p>5HT-1B/1D</p> Signup and view all the answers

    Which drug is utilized for opioid deaddiction?

    <p>Naltrexone</p> Signup and view all the answers

    Which laboratory test is used for monitoring enoxaparin?

    <p>None of the above</p> Signup and view all the answers

    What is the mechanism of colchicine in acute gout?

    <p>Prevention of granulocyte migration</p> Signup and view all the answers

    Which medication is most suitable for managing urinary incontinence in a patient taking Donepezil?

    <p>Trospium</p> Signup and view all the answers

    What is the mechanism of action of the most commonly used drug for chemotherapy-induced vomiting?

    <p>5HT3-blocker</p> Signup and view all the answers

    Which of the following agents causes mydriasis plus cycloplegia?

    <p>Cyclopentolate</p> Signup and view all the answers

    Which drug is likely responsible for causing biliary colic pain in a patient receiving post-operative pain management?

    <p>Morphine</p> Signup and view all the answers

    Which drug is not used in the treatment of sickle cell anemia?

    <p>Denosumab</p> Signup and view all the answers

    What is the mechanism of action for the drug that causes darkening of the eye in glaucoma treatment?

    <p>PGF2-Alpha agonist</p> Signup and view all the answers

    Which of the following statements about competitive antagonism is true?

    <p>Km increases and Vmax remains the same</p> Signup and view all the answers

    What is the most appropriate initial therapy for a patient with urinary retention and an enlarged prostate?

    <p>Tamsulosin</p> Signup and view all the answers

    Which medication would NOT produce mydriasis?

    <p>Phenylephrine</p> Signup and view all the answers

    What is the site of action for the drug used to treat a patient presenting with symptoms of liver disease?

    <p>PCT</p> Signup and view all the answers

    In managing urinary incontinence, which medication is considered to be the most effective?

    <p>Trospium</p> Signup and view all the answers

    In which condition is the use of tiotropium contraindicated?

    <p>Urinary retention</p> Signup and view all the answers

    Which of the following statements about nesiritide is false?

    <p>It can be administered orally</p> Signup and view all the answers

    Which drug is implicated to cause gallstone formation in patients with bacterial meningitis?

    <p>Ceftriaxone</p> Signup and view all the answers

    Why is Imipenem co-administered with Cilastatin?

    <p>Cilastatin inhibits an enzyme in the kidney destroying Imipenem</p> Signup and view all the answers

    What significant side effect of Prazosin should a physician warn a geriatric patient about?

    <p>Postural hypotension</p> Signup and view all the answers

    Which of the following drugs is an ATP synthase inhibitor?

    <p>Bedaquiline</p> Signup and view all the answers

    Which medication would be a first-line treatment for relieving symptoms of postherpetic neuralgia?

    <p>Gabapentin</p> Signup and view all the answers

    In a patient requiring a dose reduction of 6-Mercaptopurine, which drug should be adjusted?

    <p>Allopurinol</p> Signup and view all the answers

    Which of the following non-sedating antihistamines would be appropriate for a patient with urticaria following seafood consumption?

    <p>Fexofenadine</p> Signup and view all the answers

    Which medication might contribute to hirsutism in a patient with epilepsy?

    <p>Phenytoin</p> Signup and view all the answers

    What better alternative drug would you choose for a patient experiencing postural hypotension on Prazosin?

    <p>Silodosin</p> Signup and view all the answers

    Which diuretic is the preferred choice for a patient with cerebral edema following head trauma?

    <p>Mannitol</p> Signup and view all the answers

    The congenital condition phocomelia is primarily associated with the use of which medication during pregnancy?

    <p>Thalidomide</p> Signup and view all the answers

    In the case of a 2-month pregnant female with plasmodium vivax malaria, what is the recommended treatment?

    <p>Chloroquine</p> Signup and view all the answers

    Which agent is most likely to trigger acute bronchial asthma after glaucoma treatment?

    <p>Latanoprost</p> Signup and view all the answers

    What medication could lead to constipation, blurred vision, and dry mouth in a patient with schizophrenia?

    <p>Benzhexol</p> Signup and view all the answers

    In acute heart failure with pulmonary edema, which drug would be most beneficial for improving cardiac output?

    <p>Dobutamine</p> Signup and view all the answers

    Following treatment for OP poisoning, what could explain a patient's hyperthermia if treated with atropine?

    <p>Side effects of atropine</p> Signup and view all the answers

    In a case of central nervous system depression from drug overdose, which drug might require sodium bicarbonate as part of its treatment?

    <p>Phenobarbitone</p> Signup and view all the answers

    Study Notes

    Pharmacology Subject Wise Test

    • Question 1: A 27-year-old female, with irregular heartbeat, weight loss, excessive hunger, sweating, heat intolerance, and difficulty sleeping, might have been prescribed Propranolol.

    Mechanisms of Action of Sulfonylureas

    • Inhibit ATP-sensitive potassium channels

    Schizophrenia Patient

    • A patient with schizophrenia taking haloperidol (5 mg) presented with oculogyric crisis (involuntary eye movement) the next day. The patient did not have abnormal neurological findings.

    Antiarrhythmic Drug Contraindications

    • Amiodarone is contraindicated in patients with interstitial lung disease.

    Monoclonal Antibody for Alzheimer's

    • Adacanumab is a monoclonal antibody used for Alzheimer's treatment.

    Pregnancy and Hypertension Medication

    • Drugs like Perindopril should not be used in pregnant women with hypertension.

    Exercise Induced Asthma

    • A 64-year-old man with difficulty breathing during brisk walking, normal cardiac evaluation and elevated IOP, should avoid medication like Apraclonidine.

    Pregnancy and Anti-Epileptic Drugs

    • Levitiracetam is the safest antiepileptic drug taken during pregnancy.

    Fibrates Mechanism of Action

    • Fibrates increase lipoprotein lipase activity by binding to bile acid receptors.

    Drugs for Central Diabetes Insipidus

    • Desmopressin is the drug of choice for central diabetes insipidus.

    Adrenaline Concentration

    • 1:10000 is the intravenous (I/V) concentration of adrenaline used in cardiac arrest.

    Alpha-Blocker for BPH

    • Tamsulosin is an alpha-blocker used for the treatment of benign prostatic hyperplasia (BPH) that does not produce hypotension.

    Gynecomastia Causes

    • Drugs like Digoxin, Amiloride, Cimetidine, and Spironolactone can cause gynecomastia.

    Phase IV Clinical Trials

    • Minimum duration of a Phase IV clinical trial is 10 years to help assess long-term effects.

    Warfarin and CYP450

    • Cimetidine inhibits CYP450 enzymes and is associated with Warfarin.

    Alkaline Diuresis in Poisoning Cases

    • Alkaline diuresis is performed to treat poisonings from morphine, amphetamine, aspirin, and atropine.

    Enzyme Interference in MI Patient

    • A patient with suspected MI and taking blood thinners like clopidogrel might face problems if the drug interactions with CYP enzymes like CYP3A4 are present.

    Antidote of Dabigatran

    • Idarucizumab is the antidote for dabigatran.

    Anaphylactic Shock and Hypotension

    • Phentolamine can cause hypotension in patients receiving adrenaline for anaphylactic shock.

    Drugs for Rheumatoid Arthritis (RA) and Corneal Opacity

    • Drugs like Sulphasalazine, Chloroquine, Methotrexate and Leflunomide are used in RA, however, Sulfasalazine might cause corneal opacity.

    Treatment for Beta-Lactamase Producing Klebsiella Pneumoniae

    • Beta-lactams and beta-lactamase inhibitors such as ampicillin and penicillin are the drug of choice.

    Drug for Meningococcal Meningitis

    • Rifampicin is the drug of choice for chemoprophylaxis of meningococcal meningitis.

    Antimicrobials for Asthma Patients

    • Erythromycin, Cefotaxime, and Cotrimoxazole can be given to patients with asthma but erythromycin is contraindicated.

    Treatment for Cytokine Storm

    • Tocilizumab, a class of drugs called SAARDs, can be used in treating cytokine storm by inhibiting IL-6.

    Drug for Pneumonia Caused by Pneumocystis Jeroveci

    • Cotrimoxazole is the drug of choice for treating pneumonia caused by Pneumocystis Jeroveci.

    Anti-Parkinsonian Drugs and Vasospasm

    • Levodopa is an antiparkinsonian drug that can cause peripheral vasospasms.

    Competitive Antagonism

    • Km is unchanged in competitive antagonism while Vmax is increased.

    Drug for Myasthenia Gravis

    • Acetylcholinesterase (AchE) inhibitors are used in treating myasthenia gravis.

    Drugs that Increase Prolactin Levels

    • Risperidone shows maximum increase in prolactin levels.

    NSAID Induced Ulcer Treatment

    • Proton pump inhibitors (PPIs) are the best treatment for NSAID induced ulcers.

    Adverse Effects of Salbutamol

    • Avoiding hypokalemia, palpitations and tremors is important when taking Salbutamol.

    Drug Use in Chemotherapy-Induced Vomiting

    • Palonosetron is a drug used for reducing chemotherapy-induced vomiting.

    Anti-emetics and Extrapyramidal Symptoms

    • Metoclopramide is an antiemetic that is associated with extrapyramidal symptoms.

    Anti-neoplastic Drug Cell Cycle Specificity

    • Vincristine is a cell-cycle-specific anti-neoplastic drug acting on the S-phase.

    Chemotherapy-Induced Cardiotoxicity Drug

    • Doxorubicin is an anti-neoplastic drug with high cardiotoxicity.

    Hemorrhagic Cystitis Cause

    • Cyclophosphamide can cause hemorrhagic cystitis.

    Botulinum Toxin Action

    • Inhibiting acetylcholine release from the presynaptic nerve terminal is the mechanism of botulinum toxin action.

    Hyperthermia from Pralidoxime

    • Side effects like hyperthermia may be observed when treated with pralidoxime for OP poisoning.

    Drug for Nocturnal Enuresis

    • Imipramine is an effective antidepressant and can be used to treat nocturnal enuresis.

    Treatment for Glaucoma and Bronchial Asthma

    • Latanoprost, Apraclonidine, and Timolol can induce bronchospasm in an existing asthma patient.

    Drug Interactions in TB Treatment

    • Isoniazid, Rifampicin, and Pyrazinamide must not be administered together.

    Drug for Maintaining Ductus Patency

    • Alprostadil is the drug of choice for maintaining the patency of the ductus arteriosus in newborns.

    Drugs for Treatment of Hypertension (HTN)

    • Different drugs like (Labetalol, Nitroprusside, Phenoxybenzamine, and Phentolamine) have different mechanisms in managing hypertension.

    Drug for Atrial fibrillation Post myocardial Infarction

    • DOACs (direct oral anticoagulants) like Warfarin is the drug of choice to prevent blood clots in patients with previously diagnosed AF.

    Drugs for preventing potassium depletion in CHF patients

    • Amiloride, and Acetazolamide.

    Causes of Urinary Incontinence in 75 year old male

    • Drugs like (Donepazil) can cause urinary incontinence.

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    Description

    Test your knowledge on various topics in pharmacology including drug mechanisms, contraindications, and specific patient cases. This quiz covers important medications and their effects on different health conditions. Ideal for students and professionals in the medical field.

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