Pharmacology Quiz on Antibiotics and Reactions
44 Questions
7 Views

Choose a study mode

Play Quiz
Study Flashcards
Spaced Repetition
Chat to Lesson

Podcast

Play an AI-generated podcast conversation about this lesson

Questions and Answers

Which type of hypersensitivity reaction is characterized by symptoms appearing within 2 to 30 minutes after exposure?

  • Delayed
  • Minor
  • Accelerated
  • Immediate (correct)
  • A patient is prescribed amoxicillin. Which of the following adverse effects should the nurse monitor for?

  • Rash and diarrhea (correct)
  • Hypoglycemia and tremors
  • Bradycardia and hypertension
  • Constipation and abdominal pain
  • Which of the following best describes the extended antimicrobial spectrum that amoxicillin/clavulanate provides?

  • Increased activity against gram-positive bacteria
  • Effective against penicillinase-resistant bacteria
  • Extends coverage to penicillinase-sensitive bacteria (correct)
  • Effective against fungal infections
  • A patient with renal impairment is prescribed amoxicillin. What adjustment might be necessary?

    <p>Reduce the dose (D)</p> Signup and view all the answers

    Nafcillin is categorized as which type of penicillin?

    <p>Penicillinase-resistant (A)</p> Signup and view all the answers

    A patient with acute cystitis is prescribed an antibiotic but has a history of poor medication adherence. Which medication would be most suitable?

    <p>Fosfomycin (B)</p> Signup and view all the answers

    Which of the following is a typical symptom not associated with acute cystitis?

    <p>Severe flank pain (D)</p> Signup and view all the answers

    A young child presents with fever, chills, and severe flank pain. Which condition is most likely the cause?

    <p>Acute uncomplicated pyelonephritis (B)</p> Signup and view all the answers

    A patient is diagnosed with acute bacterial prostatitis due to E. coli. After initial IV treatment, what oral antibiotic is most appropriate for this patient?

    <p>Doxycycline (A)</p> Signup and view all the answers

    A patient receiving an antibiotic has a new onset of a widespread rash and fever, what is the most appropriate nursing action?

    <p>Withhold the antibiotic and inform the health provider. (B)</p> Signup and view all the answers

    A pregnant adolescent is prescribed tetracycline for acne. What should the nurse advise her?

    <p>Tetracycline can be harmful to the baby’s teeth and should be avoided. (A)</p> Signup and view all the answers

    A 6-week-old infant develops a severe cough and is awaiting culture results. Which antibiotic is most likely to be administered, before results are back?

    <p>Erythromycin ethylsuccinate (A)</p> Signup and view all the answers

    What is a primary use of aminoglycosides?

    <p>Treating infections caused by aerobic gram-negative bacilli (B)</p> Signup and view all the answers

    Which adverse effect is a major concern when administering aminoglycosides?

    <p>Nephrotoxicity and ototoxicity (D)</p> Signup and view all the answers

    A patient receiving gentamicin is showing signs of ototoxicity. What medication is the DOC to reverse this?

    <p>Calcium gluconate (B)</p> Signup and view all the answers

    What is the primary mechanism of action for bactericidal antibiotics?

    <p>Directly causing bacterial cell death (C)</p> Signup and view all the answers

    When should a sample for peak level of gentamicin be taken after an IM injection?

    <p>30 minutes after injection (D)</p> Signup and view all the answers

    Which statement best describes the concept of selective toxicity in antimicrobial drugs?

    <p>The drug is highly toxic to microbes while minimally harmful to the host (D)</p> Signup and view all the answers

    Which statement is correct about amikacin, compared to other aminoglycosides?

    <p>It is active against the broadest spectrum of gram-negative bacilli and is least vulnerable to inactivation. (C)</p> Signup and view all the answers

    A patient is prescribed gentamicin. What specific value must the nurse monitor to prevent ototoxicity?

    <p>The trough levels (B)</p> Signup and view all the answers

    What is a common mechanism by which bacteria acquire resistance to antimicrobial drugs?

    <p>Producing a drug antagonist (B)</p> Signup and view all the answers

    What is a superinfection, in the context of antimicrobial use?

    <p>A new infection that arises as a consequence of the treatment of a primary infection. (A)</p> Signup and view all the answers

    Which of the following is NOT a mechanism of action for antimicrobial drugs?

    <p>Increasing the rate of DNA replication within the host cells (D)</p> Signup and view all the answers

    What action is most important to delay the emergence of drug resistance?

    <p>Promoting patient adherence to prescribed antibiotic regimens (C)</p> Signup and view all the answers

    What is a main reason why antibiotic combinations are sometimes indicated?

    <p>To reduce the risk of severe infections and reduce toxicity (A)</p> Signup and view all the answers

    A patient is prescribed nitrofurantoin for a lower urinary tract infection. Which of the following adverse effects should the nurse monitor for most closely?

    <p>Pulmonary reactions such as cough and dyspnea (B)</p> Signup and view all the answers

    Which of the following is NOT a typical situation for prophylactic use of antibiotics?

    <p>In individuals with viral infections (A)</p> Signup and view all the answers

    A provider is considering prescribing ciprofloxacin, but the patient has a history of tendonitis. Which action should the nurse advocate for?

    <p>Recommending an alternative antibiotic due to the potential for tendon rupture (C)</p> Signup and view all the answers

    A patient with a known allergy to penicillin is prescribed amoxicillin. What is the best course of action?

    <p>Withhold the medication and immediately notify the prescriber of the allergy. (D)</p> Signup and view all the answers

    Why is it important for patients to complete their full course of antibiotics, even if they start feeling better?

    <p>To ensure maximum exposure to the drug without developing resistant organisms. (C)</p> Signup and view all the answers

    A patient with a confirmed E. faecalis infection is being discharged. Which of the following treatment plans is consistent with the recommendation?

    <p>Intravenous ampicillin/sulbactam followed by oral amoxicillin, levofloxacin, or doxycycline (D)</p> Signup and view all the answers

    A patient is prescribed nitrofurantoin for a UTI complicated by a history of renal calculi. What special instruction should the nurse include in patient education?

    <p>Monitor for new or worsening neurological symptoms (B)</p> Signup and view all the answers

    A patient being treated for anthrax should receive which medication as the drug of choice?

    <p>Ciprofloxacin (D)</p> Signup and view all the answers

    Which of the following is a common side effect of fluoroquinolones like ciprofloxacin that requires specific patient education?

    <p>Increased risk of developing a yeast infection (D)</p> Signup and view all the answers

    A 75 year old patient with a history of taking glucocorticoids is prescribed ciprofloxacin. Which adverse effect is a higher risk for this patient?

    <p>Tendon Rupture (C)</p> Signup and view all the answers

    Which statement accurately describes the mechanism of action of nitrofurantoin as a urinary tract antiseptic?

    <p>It is bacteriostatic at low concentrations and bactericidal at high concentrations. (D)</p> Signup and view all the answers

    Which of the following describes the mechanism of action for amphotericin B?

    <p>Increases permeability of the fungal cell membrane. (C)</p> Signup and view all the answers

    A patient with blastomycosis is prescribed a medication that inhibits ergosterol synthesis as its mechanism of action. Which of the following medications is MOST likely prescribed?

    <p>Fluconazole (D)</p> Signup and view all the answers

    A patient taking metronidazole reports the onset of peripheral neuropathy. Which of the following adverse effects is the patient most likely experiencing?

    <p>Neurotoxicity (B)</p> Signup and view all the answers

    A nurse is reviewing the medication list of a patient who is prescribed oral ciprofloxacin. Which of the following substances should the nurse instruct the patient to avoid ingesting concurrently with this medication?

    <p>Aluminum antacids (D)</p> Signup and view all the answers

    A patient is prescribed ketoconazole. Which of the following adverse effects should the nurse monitor for?

    <p>Hepatotoxicity (D)</p> Signup and view all the answers

    A patient with a C. difficile infection is prescribed metronidazole. Which of the following describes the mechanism of action of metronidazole?

    <p>A bactericidal medication (A)</p> Signup and view all the answers

    Which of the following is the drug of choice for most systemic mycoses?

    <p>Amphotericin B (A)</p> Signup and view all the answers

    A patient with a history of asthma is taking theophylline and has been prescribed metronidazole for a C. difficile infection. What potential drug interaction should the nurse be MOST concerned about?

    <p>Increased levels of theophylline (D)</p> Signup and view all the answers

    Flashcards

    Antibiotic

    A chemical produced by one microbe that can harm other microbes.

    Antimicrobial drug

    Any agent, natural or synthetic, that can kill or suppress microorganisms.

    Selective toxicity

    The ability of a drug to injure a target cell or organism without injuring other cells or organisms in contact with the target.

    Bactericidal

    Drugs that are directly lethal to bacteria at clinically achievable concentrations.

    Signup and view all the flashcards

    Bacteriostatic

    Drugs that slow bacterial growth without causing cell death.

    Signup and view all the flashcards

    Acquired resistance to antimicrobial drugs

    The development of resistance by organisms over time to antimicrobial drugs.

    Signup and view all the flashcards

    How antibiotic use promotes resistance

    Antibiotic use promotes resistance by various mechanisms, including decreased drug concentration, drug inactivation, altered drug target structure, and production of drug antagonists.

    Signup and view all the flashcards

    Superinfection

    An infection that appears during treatment for a primary infection.

    Signup and view all the flashcards

    Prophylactic use of antibiotics

    Using antibiotics to prevent infection in situations like surgery, bacterial endocarditis, and neutropenia.

    Signup and view all the flashcards

    Match the drug with the bug

    Matching the right antibiotic to the specific organism causing the infection.

    Signup and view all the flashcards

    Penicillin allergy

    A type of allergic reaction that can occur in some people after they are exposed to penicillin. Common symptoms include rash, diarrhea, and in the most severe cases, life-threatening anaphylaxis.

    Signup and view all the flashcards

    Cephalosporins

    A group of antibiotics that are structurally similar to penicillin and can also cause allergic reactions in some people. Therefore, people who are allergic to penicillin should avoid cephalosporins.

    Signup and view all the flashcards

    Nafcillin

    A type of antibiotic known as a penicillinase-resistant penicillin. It is used to treat infections caused by bacteria that produce penicillinase, an enzyme that can break down penicillin.

    Signup and view all the flashcards

    Broad-spectrum antibiotics

    Antibiotics that are used to treat a wide range of bacterial infections. They work by interfering with the production of bacterial cell walls, which leads to the death of the bacteria.

    Signup and view all the flashcards

    Amoxicillin/clavulanate (Augmentin)

    A penicillin antibiotic that is combined with a substance called clavulanate to extend its antibiotic activity. This combination helps fight off a wider range of bacteria, including those that produce penicillinase.

    Signup and view all the flashcards

    Why is tetracycline harmful during pregnancy?

    Tetracycline is a drug that can harm the developing baby's teeth and bones.

    Signup and view all the flashcards

    What are aminoglycosides and what are their main risks?

    Aminoglycosides are a class of antibiotics that target gram-negative bacteria. They can be dangerous to the ears and kidneys.

    Signup and view all the flashcards

    What is gentamicin used for and what are its potential side effects?

    Gentamicin is an aminoglycoside antibiotic used for serious infections caused by gram-negative bacteria. It can cause hearing loss and kidney damage.

    Signup and view all the flashcards

    What is amikacin and its main feature?

    Amikacin is an aminoglycoside antibiotic that is effective against a wider range of gram-negative bacteria compared to other aminoglycosides. However, like other aminoglycosides it can cause hearing loss and kidney damage.

    Signup and view all the flashcards

    Why monitor kidney function when a patient is taking gentamicin?

    To prevent ototoxicity (hearing loss) from gentamicin, it is important to monitor the patient's kidney function.

    Signup and view all the flashcards

    What are peak and trough levels of an antibiotic?

    The peak level of an antibiotic is the highest concentration in the blood after administration, while the trough level is the lowest concentration before the next dose. Monitoring these levels helps ensure the antibiotic reaches effective levels to fight infection and avoid toxicity.

    Signup and view all the flashcards

    How are aminoglycosides monitored and why?

    Aminoglycosides are monitored using peak and trough levels to ensure effective treatment and minimize side effects. Peak levels should be high enough to kill bacteria, while trough levels should be low enough to minimize toxicity.

    Signup and view all the flashcards

    Nitrofurantoin (Macrodantin)

    A type of antibiotic used to treat urinary tract infections (UTIs). It exerts different actions depending on concentration: low concentrations are bacteriostatic (inhibit bacterial growth) and high concentrations are bactericidal (kill bacteria).

    Signup and view all the flashcards

    Fluoroquinolones

    A broad-spectrum antibiotic that disrupts DNA replication and cell division in bacteria. It's effective against a variety of organisms, but can lead to tendon rupture, especially in specific populations.

    Signup and view all the flashcards

    Ciprofloxacin (Cipro)

    A specific fluoroquinolone that's effective against gram-negative and some gram-positive bacteria. It's the drug of choice for anthrax infections.

    Signup and view all the flashcards

    Ampicillin/Sulbactam

    An antibiotic combination used for serious infections. Ampicillin provides activity against gram-positive bacteria, while sulbactam inhibits bacterial enzymes that inactivate penicillin.

    Signup and view all the flashcards

    Amoxicillin

    An oral antibiotic that's a good alternative to ampicillin/sulbactam for treating infections.

    Signup and view all the flashcards

    Levofloxacin

    A broad-spectrum antibiotic that's effective against a wide range of bacteria. It's commonly used for UTIs and other infections.

    Signup and view all the flashcards

    Doxycycline

    A broad-spectrum antibiotic that's effective against a wide range of bacteria. It's often used for UTIs, sexually transmitted infections, and other infections.

    Signup and view all the flashcards

    Pyelonephritis

    A condition that occurs when a patient has fever, flank pain, and bacteriuria, suggesting a kidney infection.

    Signup and view all the flashcards

    Why avoid grapefruit juice with ciprofloxacin?

    Oral ciprofloxacin shouldn't be taken with grapefruit juice due to potential drug interactions that can raise ciprofloxacin levels and increase the risk of side effects.

    Signup and view all the flashcards

    What medication for C.difficile infection?

    Metronidazole (Flagyl) is a common antibiotic used to treat C. difficile infection, a type of bacterial infection in the gut.

    Signup and view all the flashcards

    How does Amphotericin B work?

    Amphotericin B is a broad-spectrum antifungal drug that binds to fungal cell membranes, increasing permeability and causing leakage of cellular components.

    Signup and view all the flashcards

    What are Azoles?

    Azoles are a group of antifungal drugs with a broader spectrum and lower toxicity compared to amphotericin B. They can be given orally.

    Signup and view all the flashcards

    What does Itraconazole do?

    Itraconazole is a specific type of azole antifungal drug that inhibits the synthesis of ergosterol, a crucial component of fungal cell membranes.

    Signup and view all the flashcards

    What are the potential side effects of Ketoconazole?

    Ketoconazole, another azole antifungal, is effective against various fungal infections including systemic and superficial ones. However, it comes with potential side effects.

    Signup and view all the flashcards

    What are the uses of Fluconazole?

    Fluconazole also inhibits ergosterol synthesis like Itraconazole, and is used for different fungal infections, including some types of meningitis and Candida infections.

    Signup and view all the flashcards

    Who should be cautious with Metronidazole?

    Older adults, those with myasthenia gravis, and patients taking certain drugs and foods have an increased risk of experiencing adverse effects from metronidazole.

    Signup and view all the flashcards

    Acute Cystitis

    A type of urinary tract infection (UTI) that affects the bladder, typically occurring in women of childbearing age. Symptoms include painful urination, frequent urination, and a feeling of needing to urinate urgently. It is usually treated with antibiotics like TMP/SMZ (Bactrim) or nitrofurantoin.

    Signup and view all the flashcards

    Acute Uncomplicated Pyelonephritis

    An infection of the kidneys that is often accompanied by fever, chills, and pain in the back or side. This condition is more common in young children, older adults, and women of childbearing age. Treatment usually involves antibiotics.

    Signup and view all the flashcards

    Acute Bacterial Prostatis

    This type of UTI affects the prostate gland, causing symptoms like fever, chills, pain in the pelvic area, and difficulty urinating. It is usually caused by a bacterial infection and requires antibiotics.

    Signup and view all the flashcards

    TMP/SMZ (Bactrim)

    A common antibiotic used to treat UTIs (uncomplicated ones). It can be taken orally and is generally well-tolerated. It works by killing bacteria that cause the infection.

    Signup and view all the flashcards

    Nitrofurantoin

    Another effective antibiotic for treating UTIs, often used for uncomplicated cases. It is available in oral form and works by inhibiting the growth of bacteria.

    Signup and view all the flashcards

    Study Notes

    Antibiotics & Anti-Infectives

    • Antibiotics are medicines that kill or suppress microorganisms.
    • Antimicrobial drugs can be natural or synthetic.
    • Most widely used groups of medicines (190 million doses given in hospitals each day)
    • Used to treat infectious diseases, greatly reduced morbidity and mortality from infection since the 1930s/40s.
    • Selective toxicity: ability of a drug to harm target cells (or organisms) without causing harm to other cells/organisms.
    • Highly toxic to microbes, but harmless to the host.
    • Disruption of the bacterial cell wall.
    • Inhibition of an enzyme unique to bacteria.

    Basic Principles of Antimicrobial Therapy

    • Recognize antimicrobials of choice for treating common infections.
    • Apply information about antimicrobials to patient care.
    • Explore major concepts related to antibiotic-resistant infections (culture and sensitivity results).
    • Predict and manage drug interactions.
    • Identify patient allergies/sensitivities and intervene when necessary.
    • Evaluate the effectiveness of drug treatment for a patient (document results, and act on findings).
    • Manage patients experiencing medication side effects/adverse reactions.
    • Prioritize medications given to a patient/group of patients.
    • Titrate dosage of medication based on assessment.
    • Verify the appropriateness and accuracy of medication orders.

    Classification of Antimicrobial Drugs

    • Cell membrane permeability
    • Protein synthesis
    • Nonlethal inhibitors of protein synthesis
    • Synthesis of nucleic acids
    • Antimetabolites
    • Viral enzyme inhibitors
    • Bactericidal (directly lethal to bacteria at clinically achievable concentrations)
    • Bacteriostatic (slows bacterial growth)

    Acquired Resistance to Antimicrobial Drugs

    • Over time, organisms develop resistance to antibiotics.
    • 4 basic actions that affect resistance:
      • Decrease the concentration of the drug at the target site of action.
      • Inactivate a drug.
      • Alter the structure of drug target molecules.
      • Produce a drug antagonist.

    Antibiotic Use and Drug-Resistant Microbe Emergence

    • How antibiotic use promotes resistance.
    • Antibiotics that promote resistance.
    • Extent of antibiotic use affects resistance.
    • Nosocomial infections: new infections that appear during the course of treatment for a primary infection.
    • Superinfection: new infection that appears during the course of treatment for a primary infection.
    • Delaying Emergence of Drug Resistance:
      • Promote adherence to appropriate prescribing guidelines.
      • Reduce demand for antibiotics among healthy adults.
      • Emphasize adherence to prescribed antibiotic regimens.
      • Selection of antibiotics
        • Identify organism (match drug with bug)
        • Drug sensitivity of organism

    Host Factors

    • Host factors (host defenses), site of infection, previous allergic reactions, genetic factors)
    • Drug may be ruled out owing to:
      • Allergy
      • Inability to penetrate site of infection

    Patient Variables

    • Antibiotic Combinations: advantages/disadvantages

    Prophylactic Use

    • Agents are given to prevent infection:
      • Surgery
      • Bacterial endocarditis
      • Neutropenia
      • Other indications
    • What to teach patients:
      • Do not discontinue prematurely
      • Stop and notify physician of any signs of allergic reactions
      • Notify physician of any side effects
      • Do not share with anyone else
      • Keep in a cool, dry place away from children

    Penicillins, Cephalosporins, Macrolides

    • Mechanism of action (MOA), bacterial resistance mechanisms, and side effects (adverse reactions) will vary by antimicrobial.
    • Specific antimicrobials were detailed for each of these drug classes, describing MOA, uses, side effects, and associated resistances (e.g. penicillin G, amoxicillin, clindamycin, etc).

    Aminoglycosides, Tetracyclines, Sulfonamides

    • Mechanism of action, side effects, drug-drug interactions, and usage of these drugs.

    Trimethoprim/sulfamethoxazole (Bactrim)

    • Uses, side effects, drug interactions, dosage, and patient teaching will vary.

    Nitrofurantoin

    • Use, side effects, and how resistance develops.

    Other Antimicrobials

    • Specific antimicrobials (e.g., metronidazole, vancomycin, etc.) and their detailed characteristics

    Questions (case studies)

    • Detailed questions on different scenarios and how to respond will vary from case to case.

    Studying That Suits You

    Use AI to generate personalized quizzes and flashcards to suit your learning preferences.

    Quiz Team

    Related Documents

    Antibiotics - Word Doc PDF

    Description

    Test your knowledge on the pharmacological aspects of antibiotics, including hypersensitivity reactions and appropriate medication choices for various conditions. This quiz covers crucial concepts related to the use of amoxicillin, nafcillin, and the management of infections, particularly in patients with specific comorbidities.

    More Like This

    Antibiotics
    16 questions

    Antibiotics

    UnquestionableGold avatar
    UnquestionableGold
    Major Classes of Antibiotics Flashcards
    12 questions
    Antibiotics: History and Use
    15 questions
    Use Quizgecko on...
    Browser
    Browser