30 Questions
What is another term for neuroleptic drugs?
Anti-schizophrenic drugs
What is the main characteristic of neurosis?
Anxiety
What type of psychosis is caused by head injury, alcoholism, or drugs?
Organic psychoses
What is the term for a mental impression based on misinterpretation of actual experience?
Illusion
What is the definition of psychosis?
A mental disorder of organic or emotional origin
What is a false personal belief based on incorrect inference contrary to available evidence?
Delusion
What is the main metabolite of dopamine?
Homovanillic acid
Which neurotransmitter is involved in the 5-HT hypothesis of schizophrenia?
Serotonin
What is the effect of amphetamines on the brain?
Release dopamine in the brain
What is the effect of DA antagonists on schizophrenia symptoms?
Control positive symptoms of schizophrenia
Which part of the brain is affected in schizophrenia, according to imaging studies?
Temporal lobe
What is the effect of lysergic acid diethylamide (LSD) on the brain?
Produce hallucinations and sensory disturbance
What is the mechanism of action of neuroleptic drugs?
Antagonist at DA D2 and/or D4 receptors
What is the effect of chronic use of neuroleptic drugs on DA receptors?
Increase in DA receptors and their sensitivity to DA
What is the approximate percentage of patients who experience Tardive Dyskinesia?
20-40%
Which of the following neuroleptic drugs has a strong anticholinergic action?
Clozapine
What is the effect of neuroleptic drugs on DA cells in the VTA and substantia nigra initially?
Increase the firing of DA cells
What is the characteristic of cariprazine in terms of its action on DA receptors?
Partial agonist at D3 and antagonist at 5-HT2 receptors
What is the effect of neuroleptics on serum prolactin concentration?
Increase
Why is iloperidone not recommended for elderly patients?
Because it prolongs the QT interval
What is the name of the FDA-approved drug for the treatment of Tardive Dyskinesia?
Valbenazine
What is the effect of prolactin on breast tissue in both men and women?
Enlargement
When was cariprazine approved by the FDA?
September 2015
What is the main metabolic effect of atypical neuroleptic agents such as clozapine and olanzapine?
Glucose metabolism alteration
What is a potential use of neuroleptics in clinical settings?
Suppressing involuntary movement in Huntington's disease
Which of the following is a potential toxicity of Pimavanserin?
Increased death rate
What is the FDA-approved use of Pimavanserin?
Managing Parkinson's disease psychosis
What is a characteristic of Pimavanserin?
Inverse agonist and antagonist at 5-HT2A receptors
In which year was Pimavanserin approved by the FDA?
2016
What is another term for neuroleptics?
Antipsychotics
Test your knowledge on neuroleptic drugs, including definitions, pathophysiology of schizophrenia, mechanisms of action, adverse effects, and therapeutic considerations. This quiz covers the basics of neuroleptic drugs and their applications in pharmacology.
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