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Questions and Answers
Which are the mechanism of action for cyclosporine? Select all that apply
Which are the mechanism of action for cyclosporine? Select all that apply
- Calcineurin inhibitor (correct)
- Inhibits IL-2 to prevent T cell activation (correct)
- Cytochrome P450 3A4 inhibitor (correct)
- P-glycoprotein inhibitor (correct)
Which are adverse effects associated with cyclosporine? Select all that apply
Which are adverse effects associated with cyclosporine? Select all that apply
- Gingival hyperplasia (correct)
- Increased risk of infection (correct)
- HTN &/or Arrythmia (correct)
- Decreased GFR (correct)
Why do we avoid giving aspirin to pediatric patients?
Why do we avoid giving aspirin to pediatric patients?
- Because it increases the chance of Reye's syndrome (correct)
- Because it causes an increased chance of infection
- Because it leads to internal GI bleeding
- Because it causes fatal hypoglycemia
What is colchicine used for?
What is colchicine used for?
What is a consequence of cyclosporine toxicity?
What is a consequence of cyclosporine toxicity?
Prednisone, methylprednisolone and dexamethasone are examples of
Prednisone, methylprednisolone and dexamethasone are examples of
Steroids can be used to treat asthma, uticaria (hives)
Steroids can be used to treat asthma, uticaria (hives)
Which drug inhibits the synthesis of arachidonic acid ?
Which drug inhibits the synthesis of arachidonic acid ?
Osteoporosis, cushing syndrome (excess cortisol lvls), DM, myopathy, HTN, gastritis, growth suppression, adrenal suppression and increased risk of infection is associated with being adverse effects of which drug?
Osteoporosis, cushing syndrome (excess cortisol lvls), DM, myopathy, HTN, gastritis, growth suppression, adrenal suppression and increased risk of infection is associated with being adverse effects of which drug?
Which drug is used to treat lupus, rheumatoid arthritis, malaria and chronic hives
Which drug is used to treat lupus, rheumatoid arthritis, malaria and chronic hives
Which drug 's MOA inhibits dendritic immune cells to prevent cell signaling needed for inflammation and immune response?
Which drug 's MOA inhibits dendritic immune cells to prevent cell signaling needed for inflammation and immune response?
Which drug is associated with adverse effects that mimic heart failure and could produce thoughts of suicide and hallucinations?
Which drug is associated with adverse effects that mimic heart failure and could produce thoughts of suicide and hallucinations?
Which drug is associated with adverse effects including folate deficiency, myelosuppression and renal dysfunction?
Which drug is associated with adverse effects including folate deficiency, myelosuppression and renal dysfunction?
Which drug is a transition analogue of folic acid; working to inhibit the enzyme dihydrofolate reductase (MOA)
Which drug is a transition analogue of folic acid; working to inhibit the enzyme dihydrofolate reductase (MOA)
Study Notes
Cyclosporine
- Inhibits arachidonic acid
- Can cause hyperglycemia
- Mechanism: blocks dendritic cells, inhibits IL-2, and T cell activation
- Side effects: gingival hyperplasia, myelosuppression, and renal dysfunction
- Important to remember for high-yield board Q
Colchicine
- Potent drug
- Toxicity: can lead to folate deficiency
- Important to remember for high-yield board Q
Aspirin
- Not recommended for kids due to the risk of Reye's syndrome (increased chance of infection)
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