Podcast
Questions and Answers
What is a potential effect on the fetus when Carbamazepine is taken during pregnancy?
What is a potential effect on the fetus when Carbamazepine is taken during pregnancy?
Which of the following is a common adverse effect associated with Carbamazepine when plasma levels exceed 8.5mg/L?
Which of the following is a common adverse effect associated with Carbamazepine when plasma levels exceed 8.5mg/L?
Why is Phenobarbitone typically used as a second-line treatment for seizures in both adults and children?
Why is Phenobarbitone typically used as a second-line treatment for seizures in both adults and children?
What is a notable pharmacokinetic characteristic of Sodium Valproate mentioned in the text?
What is a notable pharmacokinetic characteristic of Sodium Valproate mentioned in the text?
Signup and view all the answers
Which of the following conditions is Carbamazepine NOT contraindicated in?
Which of the following conditions is Carbamazepine NOT contraindicated in?
Signup and view all the answers
Which statement accurately describes Carbamazepine's pharmacokinetics as outlined in the text?
Which statement accurately describes Carbamazepine's pharmacokinetics as outlined in the text?
Signup and view all the answers
What is a common indication for Phenytoin usage?
What is a common indication for Phenytoin usage?
Signup and view all the answers
Which factor can lead to a decrease in Phenytoin protein binding?
Which factor can lead to a decrease in Phenytoin protein binding?
Signup and view all the answers
What effect does concurrent carbamazepine use have on Phenytoin metabolism?
What effect does concurrent carbamazepine use have on Phenytoin metabolism?
Signup and view all the answers
Which of the following is a potential adverse effect of Phenytoin related to the skin and collagen?
Which of the following is a potential adverse effect of Phenytoin related to the skin and collagen?
Signup and view all the answers
Why is therapeutic drug monitoring crucial for patients on Phenytoin?
Why is therapeutic drug monitoring crucial for patients on Phenytoin?
Signup and view all the answers
What type of seizures is Ethosuximide primarily used to treat?
What type of seizures is Ethosuximide primarily used to treat?
Signup and view all the answers
What is the primary route of excretion for vigabatrin?
What is the primary route of excretion for vigabatrin?
Signup and view all the answers
Why does the action of vigabatrin remain prolonged?
Why does the action of vigabatrin remain prolonged?
Signup and view all the answers
Which of the following is NOT listed as an adverse effect of vigabatrin?
Which of the following is NOT listed as an adverse effect of vigabatrin?
Signup and view all the answers
What effect does oxcarbazepine have on sodium levels?
What effect does oxcarbazepine have on sodium levels?
Signup and view all the answers
In which type of seizures is clonazepam indicated for long-term use?
In which type of seizures is clonazepam indicated for long-term use?
Signup and view all the answers
What is the recommended first-line agent for status epilepticus?
What is the recommended first-line agent for status epilepticus?
Signup and view all the answers
Which drug is known for prolonging the inactivated state of Na channels and inhibiting glutamate release?
Which drug is known for prolonging the inactivated state of Na channels and inhibiting glutamate release?
Signup and view all the answers
Which anticonvulsant can induce the metabolism of carbamazepine and phenytoin?
Which anticonvulsant can induce the metabolism of carbamazepine and phenytoin?
Signup and view all the answers
Which anticonvulsant is contraindicated in hepatic or renal impairment?
Which anticonvulsant is contraindicated in hepatic or renal impairment?
Signup and view all the answers
Which anticonvulsant has a pharmacokinetic profile with 55% oral absorption and is metabolized in the liver by glucuronidation?
Which anticonvulsant has a pharmacokinetic profile with 55% oral absorption and is metabolized in the liver by glucuronidation?
Signup and view all the answers
Which anticonvulsant is known for being reserved for resistant epilepsy due to significant irreversible visual defects?
Which anticonvulsant is known for being reserved for resistant epilepsy due to significant irreversible visual defects?
Signup and view all the answers
Which anticonvulsant can attenuate neuronal excitation by blocking Na channels and enhancing GABA mediated inhibition?
Which anticonvulsant can attenuate neuronal excitation by blocking Na channels and enhancing GABA mediated inhibition?
Signup and view all the answers
Which medication prolongs the inactivated state of voltage-dependent Na⁺ and Ca⁺⁺ channels?
Which medication prolongs the inactivated state of voltage-dependent Na⁺ and Ca⁺⁺ channels?
Signup and view all the answers
Which drug enhances the effects of the inhibitory neurotransmitter GABA?
Which drug enhances the effects of the inhibitory neurotransmitter GABA?
Signup and view all the answers
Which medication inhibits the effects of the excitatory neurotransmitter Glutamate by modulating NMDA receptors?
Which medication inhibits the effects of the excitatory neurotransmitter Glutamate by modulating NMDA receptors?
Signup and view all the answers
What is the mechanism of action of Benzodiazepines like Clonazepam and Diazepam on GABA receptors?
What is the mechanism of action of Benzodiazepines like Clonazepam and Diazepam on GABA receptors?
Signup and view all the answers
Which drug blocks GABA-A receptor complex activity and is used to prevent seizure spread?
Which drug blocks GABA-A receptor complex activity and is used to prevent seizure spread?
Signup and view all the answers
What is the main effect of GABA binding to receptor-operated chloride channels in the GABA receptor-channel complex?
What is the main effect of GABA binding to receptor-operated chloride channels in the GABA receptor-channel complex?
Signup and view all the answers
