Pharmacology of anemia

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What is the primary defining characteristic of anemia?

Decreased number of circulating red blood cells (correct)

Decreased number of plasma proteins

Decreased number of white blood cells

Decreased number of platelets

Which factor contributes to anemia according to the text?

Abnormally high total hemoglobin content

Decreased number of red blood cells or low hemoglobin content (correct)

Increased number of circulating red blood cells

Normal hemoglobin concentration

What would be the likely effect of anemia on plasma hemoglobin concentration?

Decreased plasma hemoglobin concentration (correct)

No impact on plasma hemoglobin concentration

Elevated concentration of plasma hemoglobin

Normal plasma hemoglobin concentration

How does anemia affect the total hemoglobin content per unit of blood volume?

Decreases it abnormally Signup and view all the answers

Which of the following conditions may lead to anemia?

Decreased number of circulating red blood cells Signup and view all the answers

Which factor does NOT contribute to folate/vitamin B9 deficiency according to the text?

High-folate diet Signup and view all the answers

What is a common cause of folate/vitamin B9 deficiency among individuals consuming dihydrofolate reductase inhibitors?

Reduced folate metabolism Signup and view all the answers

How does alcohol contribute to folate/vitamin B9 deficiency?

By preventing folate metabolism Signup and view all the answers

Which group is particularly susceptible to folate/vitamin B9 deficiency based on the information provided?

Pregnant women Signup and view all the answers

What effect does poor absorption have on folate levels in the body?

Decreases folate levels Signup and view all the answers

Why is G-CSF preferred over GM-CSF?

G-CSF has fewer side effects Signup and view all the answers

Which factor influences the preference for G-CSF over GM-CSF?

Toxicity profile Signup and view all the answers

What is the main advantage of choosing G-CSF over GM-CSF?

Lower likelihood of allergic reactions Signup and view all the answers

In comparison to GM-CSF, why is G-CSF a preferred choice for granulocyte stimulation?

GM-CSF leads to more hematological toxicities Signup and view all the answers

What feature of G-CSF makes it a more appealing option when compared to GM-CSF?

Decreased incidence of nausea and vomiting Signup and view all the answers

Why is it recommended to use ferrous sulfate?

It is safer compared to other iron supplements. Signup and view all the answers

What is a logical reason provided for choosing ferrous sulfate?

The question specifically mentioned ferrous sulfate. Signup and view all the answers

Which aspect makes ferrous sulfate a preferred choice?

It has a lower risk of gastrointestinal irritation. Signup and view all the answers

What sets ferrous sulfate apart from other iron supplements?

Ferrous sulfate has a higher bioavailability than other iron supplements. Signup and view all the answers

Why might someone choose ferrous sulfate over alternative options?

Ferrous sulfate has a lower likelihood of causing constipation. Signup and view all the answers

What is the main reason for using Sargramostim over other stimulants?

It has a broad-spectrum stimulant effect on the three major cell lines in the bone marrow Signup and view all the answers

Why is stimulating multiple cell lines in the bone marrow important?

To achieve a broad-spectrum stimulant effect Signup and view all the answers

What distinguishes Sargramostim from other stimulants in terms of its effect?

It has a broad-spectrum stimulant effect on different cell lines in the bone marrow Signup and view all the answers

Which characteristic makes Sargramostim stand out as a stimulant?

Its ability to stimulate all three major cell lines in the bone marrow Signup and view all the answers

What sets Sargramostim apart in terms of its impact on the bone marrow cell lines?

It provides a broad stimulant effect that other stimulants lack Signup and view all the answers

What is a potential drawback of choosing oral administration for treating iron deficiency anemia?

Less effectiveness in severe cases Signup and view all the answers

How do drug interactions with iron supplements impact their effectiveness?

Negatively affect the interactions Signup and view all the answers

Why might a healthcare provider choose intravenous administration over oral administration for iron deficiency anemia treatment?

To hasten the recovery process Signup and view all the answers

Which statement accurately reflects a common side effect associated with oral iron supplementation?

Significant gastrointestinal discomfort Signup and view all the answers

How do different formulations of iron supplements affect the likelihood of drug interactions?

Potentially lead to drug interactions Signup and view all the answers

What impact does high doses of iron formulations have on its absorption?

Reduces its absorption Signup and view all the answers

Which of the following is a common side effect associated with iron supplements?

Constipation Signup and view all the answers

In what way can high doses of iron formulations impact the effectiveness of the supplement?

Reduce the effectiveness by lowering absorption rates Signup and view all the answers

What may happen to the absorption of iron when taken with certain medications?

Decreased absorption due to interactions Signup and view all the answers

Which of the following methods is NOT a common way to administer iron supplements?

Subcutaneous injection Signup and view all the answers

What is a key consideration to keep in mind before administering iron supplements to a patient?

Reviewing the patient's medical history for drug interactions Signup and view all the answers

Which mechanism decreases the bioavailability of certain drugs when taken concurrently with iron supplements?

Formation of iron-drug complexes through chelation Signup and view all the answers

What effect does the concurrent ingestion of iron supplements have on the bioavailability of certain drugs?

Causes a marked decrease in bioavailability Signup and view all the answers

In the context of drug interactions, why is it important to seek alternative medications when a patient is already taking iron supplements?

To prevent interference with the absorption of other drugs Signup and view all the answers

What is a potential consequence of not considering a patient's existing drug regimen before administering iron supplements?

Reduced bioavailability of certain drugs Signup and view all the answers