Pharmacology of anemia
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Questions and Answers

What is the primary defining characteristic of anemia?

  • Decreased number of circulating red blood cells (correct)
  • Decreased number of plasma proteins
  • Decreased number of white blood cells
  • Decreased number of platelets

Which factor contributes to anemia according to the text?

  • Abnormally high total hemoglobin content
  • Decreased number of red blood cells or low hemoglobin content (correct)
  • Increased number of circulating red blood cells
  • Normal hemoglobin concentration

What would be the likely effect of anemia on plasma hemoglobin concentration?

  • Decreased plasma hemoglobin concentration (correct)
  • No impact on plasma hemoglobin concentration
  • Elevated concentration of plasma hemoglobin
  • Normal plasma hemoglobin concentration

How does anemia affect the total hemoglobin content per unit of blood volume?

<p>Decreases it abnormally (A)</p> Signup and view all the answers

Which of the following conditions may lead to anemia?

<p>Decreased number of circulating red blood cells (B)</p> Signup and view all the answers

Which factor does NOT contribute to folate/vitamin B9 deficiency according to the text?

<p>High-folate diet (D)</p> Signup and view all the answers

What is a common cause of folate/vitamin B9 deficiency among individuals consuming dihydrofolate reductase inhibitors?

<p>Reduced folate metabolism (A)</p> Signup and view all the answers

How does alcohol contribute to folate/vitamin B9 deficiency?

<p>By preventing folate metabolism (B)</p> Signup and view all the answers

Which group is particularly susceptible to folate/vitamin B9 deficiency based on the information provided?

<p>Pregnant women (C)</p> Signup and view all the answers

What effect does poor absorption have on folate levels in the body?

<p>Decreases folate levels (C)</p> Signup and view all the answers

Why is G-CSF preferred over GM-CSF?

<p>G-CSF has fewer side effects (C)</p> Signup and view all the answers

Which factor influences the preference for G-CSF over GM-CSF?

<p>Toxicity profile (A)</p> Signup and view all the answers

What is the main advantage of choosing G-CSF over GM-CSF?

<p>Lower likelihood of allergic reactions (D)</p> Signup and view all the answers

In comparison to GM-CSF, why is G-CSF a preferred choice for granulocyte stimulation?

<p>GM-CSF leads to more hematological toxicities (D)</p> Signup and view all the answers

What feature of G-CSF makes it a more appealing option when compared to GM-CSF?

<p>Decreased incidence of nausea and vomiting (A)</p> Signup and view all the answers

Why is it recommended to use ferrous sulfate?

<p>It is safer compared to other iron supplements. (A)</p> Signup and view all the answers

What is a logical reason provided for choosing ferrous sulfate?

<p>The question specifically mentioned ferrous sulfate. (C)</p> Signup and view all the answers

Which aspect makes ferrous sulfate a preferred choice?

<p>It has a lower risk of gastrointestinal irritation. (D)</p> Signup and view all the answers

What sets ferrous sulfate apart from other iron supplements?

<p>Ferrous sulfate has a higher bioavailability than other iron supplements. (B)</p> Signup and view all the answers

Why might someone choose ferrous sulfate over alternative options?

<p>Ferrous sulfate has a lower likelihood of causing constipation. (C)</p> Signup and view all the answers

What is the main reason for using Sargramostim over other stimulants?

<p>It has a broad-spectrum stimulant effect on the three major cell lines in the bone marrow (A)</p> Signup and view all the answers

Why is stimulating multiple cell lines in the bone marrow important?

<p>To achieve a broad-spectrum stimulant effect (B)</p> Signup and view all the answers

What distinguishes Sargramostim from other stimulants in terms of its effect?

<p>It has a broad-spectrum stimulant effect on different cell lines in the bone marrow (D)</p> Signup and view all the answers

Which characteristic makes Sargramostim stand out as a stimulant?

<p>Its ability to stimulate all three major cell lines in the bone marrow (C)</p> Signup and view all the answers

What sets Sargramostim apart in terms of its impact on the bone marrow cell lines?

<p>It provides a broad stimulant effect that other stimulants lack (A)</p> Signup and view all the answers

What is a potential drawback of choosing oral administration for treating iron deficiency anemia?

<p>Less effectiveness in severe cases (C)</p> Signup and view all the answers

How do drug interactions with iron supplements impact their effectiveness?

<p>Negatively affect the interactions (A)</p> Signup and view all the answers

Why might a healthcare provider choose intravenous administration over oral administration for iron deficiency anemia treatment?

<p>To hasten the recovery process (B)</p> Signup and view all the answers

Which statement accurately reflects a common side effect associated with oral iron supplementation?

<p>Significant gastrointestinal discomfort (C)</p> Signup and view all the answers

How do different formulations of iron supplements affect the likelihood of drug interactions?

<p>Potentially lead to drug interactions (C)</p> Signup and view all the answers

What impact does high doses of iron formulations have on its absorption?

<p>Reduces its absorption (D)</p> Signup and view all the answers

Which of the following is a common side effect associated with iron supplements?

<p>Constipation (C)</p> Signup and view all the answers

In what way can high doses of iron formulations impact the effectiveness of the supplement?

<p>Reduce the effectiveness by lowering absorption rates (C)</p> Signup and view all the answers

What may happen to the absorption of iron when taken with certain medications?

<p>Decreased absorption due to interactions (B)</p> Signup and view all the answers

Which of the following methods is NOT a common way to administer iron supplements?

<p>Subcutaneous injection (D)</p> Signup and view all the answers

What is a key consideration to keep in mind before administering iron supplements to a patient?

<p>Reviewing the patient's medical history for drug interactions (D)</p> Signup and view all the answers

Which mechanism decreases the bioavailability of certain drugs when taken concurrently with iron supplements?

<p>Formation of iron-drug complexes through chelation (D)</p> Signup and view all the answers

What effect does the concurrent ingestion of iron supplements have on the bioavailability of certain drugs?

<p>Causes a marked decrease in bioavailability (D)</p> Signup and view all the answers

In the context of drug interactions, why is it important to seek alternative medications when a patient is already taking iron supplements?

<p>To prevent interference with the absorption of other drugs (B)</p> Signup and view all the answers

What is a potential consequence of not considering a patient's existing drug regimen before administering iron supplements?

<p>Reduced bioavailability of certain drugs (C)</p> Signup and view all the answers

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