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Questions and Answers
Which type of drug binds to receptors and decreases or blocks the action of an antagonist?
What is the measure of how much drug is required to produce a given effect?
What is the minimum dose that will kill 50% of persons in a population?
A drug with high efficacy but low potency would require what to produce a maximum response?
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What indicates a relatively low incidence of side effects at usual doses?
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What therapeutic index indicates a drug to be very safe?
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Which factor does not affect drug absorption?
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What is the dose of a drug that will produce a specific effect in 50% of the population?
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Which of the following factors does not affect drug absorption?
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What is the term that describes the amount of drug that is actually available to the body after administration?
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Which factor affects drug absorption by reducing the amount of drug available to the body?
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What is the term that describes the process by which a drug is absorbed into the bloodstream and then transported to the liver for metabolism?
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Which of the following options is not a factor that affects drug absorption?
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Study Notes
Pharmacology Concepts
- A drug that binds to receptors and decreases or blocks the action of an antagonist is an antagonist.
- Agonist is the correct answer, as it binds to receptors and increases or mimics the action of an agonist.
Pharmacological Measures
- Efficacy represents the maximum response that can be produced by a drug.
- Potency represents the dose of a drug required to produce a given effect.
Toxicology
- LD50 (Lethal Dose 50) represents the minimum dose that will kill 50% of persons in a population.
- ED50 (Effective Dose 50) represents the dose of a drug that will produce a specific effect in 50% of the population.
- TD50 (Toxic Dose 50) represents the minimum dose that will produce a specific toxic effect in 50% of the population.
Pharmacodynamic Properties
- A drug with high efficacy but low potency will produce a higher level of response with a greater dose.
- A potent drug reaches its maximum response at a lower dose.
Therapeutic Index
- Low therapeutic index indicates a relatively high incidence of side effects at usual doses.
- High therapeutic index indicates a low incidence of side effects.
Therapeutic Index and Safety
- A therapeutic index of 1 indicates a low margin of safety.
- A therapeutic index of 4 indicates a high margin of safety and the drug is very safe.
Factors Affecting Drug Absorption
- Liquid solubility affects drug absorption.
- Bioavailability affects drug absorption.
- First pass metabolism affects drug absorption.
- Route of administration affects drug absorption.
- Aqueous solubility is not a factor affecting drug absorption.
Factors Affecting Drug Absorption
- Liquid solubility is a factor that affects drug absorption.
- Bioavailability is a factor that affects drug absorption.
- First pass metabolism is a factor that affects drug absorption.
- Route of administration is a factor that affects drug absorption.
- There is no such term as "Aquarius aqueous solution" in pharmacology, so it's the exception.
- There is no such term as "Second pass metabolism" in pharmacology, so it's not a valid factor affecting drug absorption.
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Description
Multiple choice questions on pharmacology concepts, including antagonists, agonists, efficacy, and potency.
