Pharmacology of Sympathetic Nervous System

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Questions and Answers

Which class of drugs works by activating adrenoceptors to inhibit the release of noradrenaline?

Tricyclic antidepressants
Reserpine
Clonidine (correct)
Cocaine

What effect do monoamine oxidase inhibitors have on catecholamines?

They act as antagonists at adrenergic receptors.
They deplete the stores of catecholamines.
They prevent the destruction of catecholamines. (correct)
They increase the release of catecholamines.

Which drug type is primarily responsible for discharging stored noradrenaline from nerve endings?

Trimethaphan
Guanethidine
Propranolol
Amphetamine (correct)

Which drug prevents the reuptake of both noradrenaline and dopamine?

<p>Cocaine (B)</p> Signup and view all the answers

What is the primary action of guanethidine in the sympathetic nervous system?

<p>It prevents the release of noradrenaline in response to nerve impulses. (B)</p> Signup and view all the answers

Flashcards

Directly Acting Adrenergic Drugs

Drugs that work by binding to adrenoceptors on cells, mimicking the effects of adrenaline (agonists) or blocking them (antagonists).

Indirectly Acting Sympathomimetic Drugs

Drugs that increase the effects of the sympathetic nervous system without directly binding to adrenoceptors.

Discharging Noradrenaline

Drugs like amphetamine that stimulate the release of noradrenaline from nerve endings, increasing sympathetic activity.

Preventing Reuptake of Neurotransmitters

Drugs like cocaine that block the reuptake of neurotransmitters like noradrenaline, prolonging their effects.

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Activating α2 Autoreceptors

Drugs like clonidine that activate α2 autoreceptors on adrenergic nerve endings, inhibiting the release of noradrenaline, leading to a decrease in sympathetic activity.