Pharmacology: Sympathetic Nervous System and Drug Classification
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Questions and Answers

What is the role of epinephrine in the case of the 6-year-old boy with a bee sting?

  • To inhibit the release of acetylcholine at the neuromuscular junction
  • To increase blood pressure and open up the airways (correct)
  • To reduce inflammation and provide pain relief
  • To block the effect of histamine and reduce allergic symptoms
  • What is the most likely diagnosis in the case of the 6-year-old boy with a bee sting?

  • Asthma exacerbation
  • Angioedema
  • Dermatitis
  • Anaphylaxis (correct)
  • Which neurotransmitter is primarily involved in the sympathetic nervous system's response to stress?

  • Acetylcholine
  • Noradrenaline (NA)
  • Dopamine
  • Adrenaline (epinephrine) (correct)
  • Which neurotransmitter is released by the postganglionic fibers of thermoregulatory sweat glands?

    <p>Acetylcholine</p> Signup and view all the answers

    What is the primary mechanism for the termination of action of sympathetic cholinergic neurotransmitters?

    <p>Neuronal uptake</p> Signup and view all the answers

    Which drug directly stimulates all α and β receptors and is classified as a sympathomimetic?

    <p>Adrenaline</p> Signup and view all the answers

    Which of the following is a therapeutic use of noradrenaline?

    <p>Acute hypotensive state</p> Signup and view all the answers

    Dobutamine activates which of the following receptor(s)?

    <p>β1 receptor</p> Signup and view all the answers

    Which of the following is a therapeutic use of adrenaline?

    <p>Acute pulmonary edema</p> Signup and view all the answers

    What is a therapeutic use of dobutamine?

    <p>Treatment of chronic heart failure</p> Signup and view all the answers

    Study Notes

    Autonomic Nervous System and Neurotransmitters

    • In the case of a 6-year-old boy with a bee sting, epinephrine is used to counteract the allergic reaction by dilating airways, tightening blood vessels, and increasing heartbeat.
    • The most likely diagnosis in the case of the 6-year-old boy with a bee sting is anaphylaxis, a severe and life-threatening allergic reaction.

    Sympathetic Nervous System and Neurotransmitters

    • Norepinephrine is the neurotransmitter primarily involved in the sympathetic nervous system's response to stress.
    • Norepinephrine is released by the postganglionic fibers of thermoregulatory sweat glands.

    Neurotransmitter Termination

    • The primary mechanism for the termination of action of sympathetic cholinergic neurotransmitters is enzymatic degradation by acetylcholinesterase.

    Sympathomimetic Drugs

    • Epinephrine directly stimulates all α and β receptors and is classified as a sympathomimetic.
    • Noradrenaline is used to increase blood pressure in certain medical conditions, such as hypotension.
    • Dobutamine activates β1 receptors, increasing heart rate and contractility, and is used to treat cardiac failure.

    Therapeutic Uses of Neurotransmitters

    • Adrenaline is used to treat anaphylaxis and cardiac arrest.
    • Dobutamine is used to treat cardiac failure and cardiogenic shock.

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    Description

    This quiz covers the introduction to the Sympathetic Nervous System, the classification of sympathomimetic drugs, and the pharmacokinetics, pharmacodynamics, and therapeutic uses of Epinephrine, Norepinephrine, Dopamine, and Dobutamine. It also includes a case scenario related to a bee sting and treatment.

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