Pharmacology of Passion Flower

Choose a study mode

Play Quiz
Study Flashcards
Spaced Repetition
Chat to Lesson

Podcast

Play an AI-generated podcast conversation about this lesson
Download our mobile app to listen on the go
Get App

Questions and Answers

What is the primary pharmacological activity of Passion Flower?

  • Sedative and anxiolytic (correct)
  • Antioxidant
  • Antibiotic
  • Anti-inflammatory

Which of the following flavonoids is NOT listed as part of the chemical composition of Passion Flower?

  • Shaftoside
  • Isovitexin
  • Isoorientin
  • Quercetin (correct)

How does Passion Flower show its activity in the body?

  • By modulation of the GABA system (correct)
  • By enhancing the norepinephrine system
  • By inhibiting the dopamine system
  • By stimulating the serotonin system

Which of the following constituents is found in Passion Flower in a minor quantity?

<p>Indole alkaloids (B)</p> Signup and view all the answers

What other drug is commonly combined with Passion Flower for its sedative effects?

<p>Valerian (C)</p> Signup and view all the answers

Which of the following statements about the chemical composition of Passion Flower is incorrect?

<p>It contains significant amounts of harmful substances. (C)</p> Signup and view all the answers

Which part of Passion Flower is primarily used for medicinal purposes?

<p>Aerial parts (B)</p> Signup and view all the answers

What is a characteristic of flavonoid-containing drugs like Passion Flower?

<p>They may help with minor sleep disturbances. (D)</p> Signup and view all the answers

What pharmacological activity is thyme known for?

<p>Antifungal and antibacterial (D)</p> Signup and view all the answers

Which flavonoid is found in Field Horsetail (Equisetum arvense)?

<p>Quercetin 3-O-glucoside (D)</p> Signup and view all the answers

What is a traditional use of Equisetum arvense?

<p>Diuretic (B)</p> Signup and view all the answers

What type of compounds contribute to the spasmolytic activity of thyme?

<p>Phenols (B)</p> Signup and view all the answers

Which component does NOT typically belong to the chemical composition of Equisetum arvense?

<p>Essential oil (A)</p> Signup and view all the answers

What is the highest percentage of silica (SiO2) found in Equisetum arvense?

<p>5-10% (C)</p> Signup and view all the answers

Which of the following is NOT a use of Field Horsetail in cosmetology?

<p>Treatment of acne (A)</p> Signup and view all the answers

What type of toxicity is associated with Equisetum palustre?

<p>Toxicity for livestock (A)</p> Signup and view all the answers

What is a pharmacological use of Roman Camomile?

<p>Antispasmodic (B)</p> Signup and view all the answers

Which flavonoid is notably found in Immortelle flower?

<p>Kaempferol (B)</p> Signup and view all the answers

Which of the following is an essential oil component found in Yarrow?

<p>Limonene (A)</p> Signup and view all the answers

What is traditionally used for treating gastrointestinal disorders?

<p>Roman Camomile (D)</p> Signup and view all the answers

What type of compound is predominantly found in the chemical composition of Roman Camomile?

<p>Flavonoids (C)</p> Signup and view all the answers

Which property is NOT associated with Immortelle flower?

<p>Antifungal (B)</p> Signup and view all the answers

What are sesquiterpene lactones primarily known for?

<p>Bitter taste (B)</p> Signup and view all the answers

Which traditional use is linked to Immortelle flower?

<p>Treats otitis (C)</p> Signup and view all the answers

Which is a characteristic of flavonoids found in Yarrow?

<p>6-methoxylated flavones (C)</p> Signup and view all the answers

What role do flavonoids from Roman Camomile play?

<p>Act as antioxidants (D)</p> Signup and view all the answers

Which class of flavonoids is characterized by the absence of a 2,3-double bond?

<p>Flavanones (C)</p> Signup and view all the answers

What is the primary role of flavonoids in plants?

<p>Attracting insects through UV absorption (C)</p> Signup and view all the answers

Which of the following describes the structural feature of flavonoids?

<p>Contain a 2-phenylchromane skeleton (D)</p> Signup and view all the answers

Which of the following flavonoids is known to accumulate in the leaf cuticle?

<p>Free aglycones (A)</p> Signup and view all the answers

What determines the glycosidic forms of flavonoids?

<p>Water-solubility and accumulation in vacuoles (A)</p> Signup and view all the answers

Which class of flavonoids is primarily found in the families Lamiaceae, Rutaceae, and Asteraceae?

<p>6-O-substituted flavonoids (D)</p> Signup and view all the answers

What is a significant feature of chalcones in flavonoid classification?

<p>Characterized by an open C-ring (D)</p> Signup and view all the answers

In which class of flavonoids would you find compounds like catechin and leucocyanidin?

<p>Flavan-3-ols (B)</p> Signup and view all the answers

Which of the following can be a product of flavonoid bonding?

<p>Biflavonoids (D)</p> Signup and view all the answers

Which of the following is a characteristic of isoflavones?

<p>Have a distinct 3-phenylchromone structure (A)</p> Signup and view all the answers

Which flavonoid structure typically has at least one asymmetric center?

<p>Flavanones (C)</p> Signup and view all the answers

Which of the following statements about structural diversity in 2-phenylchromones is true?

<p>Substitutions mostly occur at specific carbon positions (A)</p> Signup and view all the answers

What is the significance of structural features in flavonoids regarding chemotaxonomy?

<p>They can indicate phylogenetic relationships (A)</p> Signup and view all the answers

Which variant of flavonoids can exhibit a C-C type interflavonoid linkage?

<p>Biflavonoids (D)</p> Signup and view all the answers

What types of sugars can flavonoid glycosides consist of?

<p>Hexoses and pentoses (B)</p> Signup and view all the answers

Which bond is characteristic of C-glycosides in flavonoids?

<p>C-C bond between anomeric carbon of sugar and C-6 or C-8 of aglycone (A)</p> Signup and view all the answers

What is the common property of flavonoids involving vascular health?

<p>Decrease capillary fragility (B)</p> Signup and view all the answers

Which structural elements are required for optimal free radical scavenging activity in flavonoids?

<p>Hydroxyl groups and a ketone function (D)</p> Signup and view all the answers

Which chromatographic techniques are used for the separation and purification of flavonoids?

<p>Liquid chromatography and HPLC (D)</p> Signup and view all the answers

How are glycosides extracted efficiently?

<p>With acetone or alcohol mixtures (20-50%) (B)</p> Signup and view all the answers

What are common methods of qualitative analysis for flavonoids?

<p>Thin Layer Chromatography and specific chemical reactions (A)</p> Signup and view all the answers

Which flavonoid is extracted from buckwheat?

<p>Rutin (C)</p> Signup and view all the answers

What biological property do several flavonoids exhibit regarding enzymes?

<p>They can inhibit or stimulate various enzymes (C)</p> Signup and view all the answers

Which structural adaptation makes rutin more soluble?

<p>Converting to a glycosyl derivative (C)</p> Signup and view all the answers

Which compound is known as a citroflavonoid derived from citrus fruits?

<p>Naringenin (A)</p> Signup and view all the answers

What common pharmacological application do flavonoids have?

<p>Address chronic venous insufficiency symptoms (A)</p> Signup and view all the answers

What solvent types do flavonoid glycosides typically dissolve in?

<p>Water and alcohols (C)</p> Signup and view all the answers

Flashcards

What are flavonoids?

Plant pigments responsible for colors in flowers, fruits, and sometimes leaves. They absorb near-UV radiation to attract insects and protect plant tissue.

What are chalcones and aurones?

A group of flavonoids that give yellow color to plants.

What is a copigment?

Flavonoids like anthocyanins can act as copigments, enhancing the color of other pigments.

Where are flavonoids found?

Flavonoids are widely found in plants, except algae. They have the highest diversity in flowering plants (angiosperms).

Signup and view all the flashcards

Where are glycosidic flavonoids and aglycones found?

Glycosidic forms of flavonoids are water-soluble and accumulate in plant vacuoles. Free aglycones are located in the leaf cuticle.

Signup and view all the flashcards

What is the basic structure of flavonoids?

Flavonoids share a common basic structure called a 2-phenylchromane skeleton.

Signup and view all the flashcards

How are flavonoids classified?

Flavonoids are categorized based on the oxidation state of the pyran ring. They include 2-phenylchromones, 2-phenylchromanes, and others.

Signup and view all the flashcards

What are some examples of 2-phenylchromones?

Flavones, flavonols, flavanones, and dihydroflavonols are examples of 2-phenylchromones. They are found in high concentrations in plants.

Signup and view all the flashcards

What are isoflavones and isoflavanones?

Isoflavones and isoflavanones are unique flavonoids with a 3-phenylchromone structure.

Signup and view all the flashcards

What are chalcones and dihydrochalcones?

Chalcones and dihydrochalcones have an open pyran ring and a 3-carbon chain with a ketone group. They are often found in legumes.

Signup and view all the flashcards

What are aurones?

Aurones are flavonoids with a 2-benzylidene coumaranone structure and are known for their bright yellow pigmentation.

Signup and view all the flashcards

What are anthocyanidins?

Anthocyanidins are flavonoids responsible for red, blue, and purple colors in plants. They are based on a 2-phenylbenzopyrilium core.

Signup and view all the flashcards

What are biflavonoids?

Biflavonoids are formed when two flavonoid molecules bond together. They are often found in plants with protective properties.

Signup and view all the flashcards

What are apigenin and luteolin?

Apigenin and luteolin are common flavones with hydroxyl groups at specific positions. They are known for their antioxidant properties.

Signup and view all the flashcards

What are kaempferol and quercetin?

Kaempferol and quercetin are flavonols with hydroxyl groups. They contribute to plant's defense mechanisms and have health benefits.

Signup and view all the flashcards

Biflavonoid

A type of flavonoid where two flavonoid units are linked together, often forming a dimer.

Signup and view all the flashcards

Biflavanone

A type of flavonoid that has a double bond in the C ring. They're less frequently found in nature compared to other flavonoids, but still important.

Signup and view all the flashcards

Flavone-flavanone

A type of flavonoid where one flavonoid unit is a flavone and the other is a flavanone. While less known than biflavones, they contribute to the diversity of flavonoid structures.

Signup and view all the flashcards

Flavonoid glycosides

Flavonoids that have sugars attached to them. They're more water-soluble than their aglycone counterparts. The sugars can be mono-, di- or trisaccharides.

Signup and view all the flashcards

C-glycosidic flavonoid

The type of glycosidation bond in flavonoids where the sugar unit is attached to the C-6 or C-8 position of the flavonoid aglycone through a carbon-carbon bond.

Signup and view all the flashcards

Flavonoid glycosides solubility

Flavonoids that are soluble in water and alcohols but sparingly soluble in apolar solvents.

Signup and view all the flashcards

Flavonoid aglycone solubility

Flavonoids that are soluble in apolar solvents, but are often less soluble in water than their glycosidic forms.

Signup and view all the flashcards

Chalcone

A type of flavonoid that often appears colored in thin layer chromatography (TLC) and turns orange when exposed to ammonia.

Signup and view all the flashcards

Aurone

A type of flavonoid that often appears colored in thin layer chromatography (TLC) and turns red when exposed to ammonia.

Signup and view all the flashcards

Citroflavonoid

A type of flavonoid with a specific structure that contributes to its antioxidant and anti-inflammatory properties. They are often found in citrus fruits.

Signup and view all the flashcards

Hesperidin

A common citrus flavonoid that is often used as a supplemental ingredient for its potential health benefits. It's known for its antioxidant and anti-inflammatory properties.

Signup and view all the flashcards

Ginkgo biloba extract

A popular over-the-counter flavonoid that comes from the Ginkgo biloba tree. It's known for its potential cognitive benefits.

Signup and view all the flashcards

Ginkgolide B

One of the main constituents of Ginkgo biloba extract that has been studied for its potential cognitive benefits, among other potential functions.

Signup and view all the flashcards

Rutin

A flavonoid glycoside that is abundant in various plants, and is often used for its potential health benefits.

Signup and view all the flashcards

Rutin (Sophora japonica)

A common flavonoid extracted from the Sophora japonica tree, a source of quercetin.

Signup and view all the flashcards

What is Passion Flower?

A plant that has sedative and anxiolytic properties. It can be used in minor sleep disturbances, nervousness, and in combination with other sedatives.

Signup and view all the flashcards

What are the main active compounds in Passion Flower?

The primary active compounds in Passion Flower. They are flavonoids, or more specifically flavon-C-glycosides, which must be present in a concentration of at least 1.5% for medicinal effect.

Signup and view all the flashcards

What are the active constituents in Passion Flower?

Passion Flower's chemical composition includes not only flavonoids but also other active constituents such as indole alkaloids, coumarins, cyanogenic glycosides, phytosterols, and maltol.

Signup and view all the flashcards

What are the pharmacological activities of Passion Flower?

Passion Flower's medicinal properties in calming and relaxing the nervous system. It is used in the treatment of anxiety, insomnia, and restlessness.

Signup and view all the flashcards

What is Thyme?

A plant with numerous species in the mint family. It's an herb with a strong, pungent aroma and is frequently used in traditional medicine and cooking.

Signup and view all the flashcards

What are the primary active compounds in Thyme?

The active components of Thyme that have been recognized for their pharmacological effects. They are found in varying amounts depending on the species and growing conditions.

Signup and view all the flashcards

What are the traditional medicinal uses of Thyme?

Thyme is used as a natural remedy for respiratory infections, indigestion, and skin conditions. It is often used in combination with other herbs in various remedies and supplements.

Signup and view all the flashcards

What are some important precautions when using herbs like Thyme?

It is important to note that some plants, like Thyme, may contain substances that can interact with medications or may not be suitable for everyone. Always consult a healthcare professional before using any herbal remedies.

Signup and view all the flashcards

What is Thyme used for?

Thyme (Thymus vulgaris) is a plant with a strong aroma used for medicinal and culinary purposes. Its essential oil possesses antibacterial and antifungal properties. It's also utilized as a soothing agent for gastrointestinal issues, coughs, and oral cavity problems.

Signup and view all the flashcards

What are the benefits of Field Horsetail?

Field Horsetail (Equisetum arvense) is a plant rich in minerals, particularly silica, which has a diuretic effect. It's used to promote water elimination, aiding in weight loss and preventing urinary tract issues.

Signup and view all the flashcards

What is the difference between Field Horsetail and Marsh Horsetail?

Marsh Horsetail (Equisetum palustre) is toxic to animals and potentially to humans. It's often confused with Field Horsetail which is safe for medicinal use.

Signup and view all the flashcards

What are Apigenin and Luteolin and what do they do?

Apigenin and luteolin are two common flavones found in plants with various health benefits, such as antioxidant and anti-inflammatory properties. They also contribute to the pigmentation of flowers and fruits.

Signup and view all the flashcards

Why are flavonoids important?

Flavonoids are plant pigments that play a significant role in various biological processes. They provide color to flowers and fruits, act as antioxidants, and contribute to various medicinal benefits.

Signup and view all the flashcards

What are the medicinal properties of thyme essential oil?

Thyme essential oil has a strong antifungal and antibacterial effect, making it an effective remedy for skin infections and wounds.

Signup and view all the flashcards

How does Field Horsetail benefit hair, nails, and skin?

Field Horsetail's mineral content, especially silica, strengthens hair, nails, and bones. It's also utilized in cosmetics to prevent wrinkles, skin blemishes, and cellulite.

Signup and view all the flashcards

What properties do Thyme and Field Horsetail share?

The presence of flavonoids and phenolic compounds in thyme and field horsetail contribute to their spasmolytic effect, which helps to relieve spasms in the muscles of the gastrointestinal tract.

Signup and view all the flashcards

Apigenin and Luteolin glycosides

A type of flavonoid found in Roman Camomile (Chamaemelum nobile), known for its anti-inflammatory and antispasmodic properties. It's often used for gastrointestinal issues.

Signup and view all the flashcards

6-Methoxylated Flavones

A type of plant compound found in Yarrow (Achillea millefolium), contributing to its anti-inflammatory and antispasmodic effects.

Signup and view all the flashcards

Apigenin-7-glucoside

A type of flavonoid found in Immortelle flower (Helichrysum plicatum), known for its antioxidant and anti-inflammatory activities.

Signup and view all the flashcards

Kaempferol and Quercetin glycosides

A type of flavonoid found in Immortelle flower (Helichrysum plicatum), contributing to its yellow color.

Signup and view all the flashcards

Study Notes

Flavonoids - General Overview

  • Flavonoids are universal plant pigments
  • They are responsible for the color of flowers, fruits, and sometimes leaves
  • Yellow flavonoids include chalcones and aurones
  • Red, blue, or purple flavonoids are anthocyanins
  • Flavonoids can sometimes act as copigments, affecting the color of other pigments (e.g., protecting anthocyanins)
  • Flavonoids are widespread in the plant kingdom, except for algae
  • Structural diversity of flavonoids is maximal in angiosperms
  • Glycosidic forms of flavonoids are water-soluble and accumulate in vacuoles
  • Free aglycones are located in leaf cuticles

Flavonoid Chemistry and Classification

  • Flavonoids have a "2-phenylchromane" skeleton
  • They are classified based on the degree of oxidation of the "pyran" ring
  • 2-phenylchromones include flavones, flavonols, flavanones, and dihydroflavonols
  • 2-phenylchromanes include flavans, flavan-3-ols, and flavan-3,4-diols
  • 3-phenylchromones include isoflavones and isoflavanones
  • Chalcones and dihydrochalcones have an open pyran ring
  • 2-benzylidene coumaranones are also known as aurones
  • 2-phenylbenzopyriliums are anthocyanins

Flavonoid Structure Diversity

  • Substitution at C-5 and C-7 by -OH groups occurs in 90% of flavonoids.
  • Flavonoids can be free or etherified (-OMe)
  • Commonly, they are engaged in glycosidic linkages (O-glc...)
  • These can also be substituted at C-6 and C-8;
  •   Free or etherified -OH groups
  • Isoprenylation
  • Methylation
  • C-glycosylation and substitution at B ring
  • Examples of B-ring substitutions include C-4'-OH, 3',4'-di OH, and 3',4',5'-tri OH.

Flavonoid Characterization

  • Flavones and dihydroflavonols are characterized by the absence of a 2,3-double bond
  • At least one asymmetric center is present
  • C-2 is generally in the S configuration

Flavonoid-3-ol and Flavon-3,4-diols

  • These are 2-phenylchromanes
  • Examples include catechin and leucocyanidin

3-Phenylchromones (Isoflavonoids)

  • Isoflavones and isoflavanones are included in this category

Chalcones

  • The C-ring of chalcones is open
  • They are characterized by a 3C-chain with a ketone function and alpha,beta-unsaturation

2-Benzylidenecoumaranone (Aurones)

  • Hispidol is an example in this category

Biflavonoids

  • Two flavonoid structures are connected to each other
  • Interflavonoid linkages can be C-C type (e.g., amentoflavone) or C-O-C type (e.g., hinokiflavone).
  • The two flavonoid units may or may not be the same type (e.g., biflavone, biflavanone, flavone-flavanone)

Flavonoid Glycosides

  • Flavonoid glycosides (O-glycosides) are mono, di, and trisaccharides
  • Common sugars include D-glucose, D-galactose, D-allose, D-apiose, L-arabinose, L-rhamnose, and D-xylose.
  • Uronic acids (D-glucuronic acid, D-galacturonic acid) are also present
  • Glycosation often happens at C-7 (OH) in flavones or C-3 (OH) in flavonols
  • Aliphatic acids (e.g., acetic, malonic, tiglic) and aromatic acids (e.g., gallic, benzoic, cinnamic) can also be attached
  • Flavonoid glycosides also have C-glycosides where the glycosidation bond occurs between the anomeric carbon of the sugar and C-6 or C-8 of the aglycone. (e.g., orientin and saponarin )

Biosynthetic Origin of Flavonoids

  • Flavonoids are biosynthesized from different starting points, leading to various classes.

Flavonoid Physicochemical Properties

  • Flavonoid glycosides are generally soluble in water and alcohols (e.g., ethanol, methanol).
  • Rutin and hesperidin are exceptions and are only sparingly soluble.
  • Aglycones are generally soluble in non-polar solvents.
  • Flavonoids that have at least one free phenolic group dissolve in alkaline hydroxide solutions.
  • Glycosides are usually extracted using mixtures of acetone or ethanol/methanol/water.
  • Common fractionation methods include liquid-liquid extraction (using immiscible solvents like petroleum ether, diethyl ether, dichloromethane, and ethyl acetate), to separate flavonoids from plant material
  • Chromatographic purification can be used to separate flavonoids (e.g. polyamide, sephadex, silica gel)
  • Qualitative analysis (TLC) and quantitative analysis (spectrophotometry, HPLC-DAD) are used.

Flavonoids - Biological properties

  • Flavonoids have various biological properties and uses, including reducing capillary fragility and permeability.
  • They act as Vitamin P, venous tonics, and can be used as topical agents in phlebology.
  • They are used for treating symptoms of venous and lymphatic insufficiency, acute piles, metrorrhagias, lymphedema.
  • Flavonoids also demonstrate free radical scavenging activity, structural requirements include two ortho-hydroxyl groups on the B ring, ketone function at C-4, and 2,3-unsaturation.
  • Some flavonoids inhibit or stimulate different enzymes (e.g., CAMP phosphodiesterase, aldose-reductase, lipooxygenase, cyclooxygenase, proline hydroxylase)
  • Other flavonoid properties include anti-inflammatory, anti-allergic, hepatoprotective, antispasmodic, blood cholesterol-decreasing, diuretic, antibacterial, antiviral, and cytostatic activity

Flavonoids - Chief Flavonoids on the Market

  • Citroflavonoids, isolated from citrus fruits
  • Rutin, from various plants (e.g., Japanese pagoda tree, buckwheat)
  • Flavonoids are extracted from pericarp and pulp as Ca and Mg derivatives
  • Flavonoids from these sources can be used alone or in combination with other compounds Also used to treat and prevent conditions like leg symptoms of chronic venous insufficiency, and the acute attack of piles.

Flavonoid-Containing Drugs

  • Different plants contain various flavonoid concentrations.
  • These flavonoids can differ in the way they are used, and in their chemical composition.
  • Examples include: Ginkgo biloba (leaves), Passiflora incarnata (aerial parts), Thymus vulgaris (aerial parts), Equisetum arvense (aerial parts), Chamaemelum nobile (flowers), and Achillea millefolium (flowers), and Helichrysum plicatum (flowers).
  • Some plants also have toxicity concerns related to their flavonoid content.

Flavonoid toxicity

  • Some flavonoids can be toxic, especially as concerns some plants used in livestock, or as adulterants of other products

Studying That Suits You

Use AI to generate personalized quizzes and flashcards to suit your learning preferences.

Quiz Team

Related Documents

Flavonoids PDF

More Like This

Passion Play
8 questions

Passion Play

HappierPurple avatar
HappierPurple
Passion at Work Quiz
15 questions

Passion at Work Quiz

FervidSagacity avatar
FervidSagacity
Passion Occupation Overload
84 questions
Passion for Animals
11 questions

Passion for Animals

IntuitiveObsidian2849 avatar
IntuitiveObsidian2849
Use Quizgecko on...
Browser
Browser