Podcast
Questions and Answers
What is the approximate analgesic potency of propoxyphene compared to morphine?
What is the approximate analgesic potency of propoxyphene compared to morphine?
- 1/10th (correct)
- 1/2
- 1/5th
- Equal
What is the main concern with the metabolism of propoxyphene?
What is the main concern with the metabolism of propoxyphene?
- It results in naloxone-insensitive cardiotoxicity (correct)
- It causes respiratory depression
- It leads to increased analgesic potency
- It increases the risk of addiction
What is the approximate percentage of tramadol's analgesic effect that is antagonized by naloxone?
What is the approximate percentage of tramadol's analgesic effect that is antagonized by naloxone?
- 40%
- 20%
- 30% (correct)
- 10%
What is the difference in potency between the (+) and (-) enantiomers of tramadol?
What is the difference in potency between the (+) and (-) enantiomers of tramadol?
What is the primary mechanism of action of naltrexone?
What is the primary mechanism of action of naltrexone?
What is the duration of action of naltrexone after a single dose of 50 mg?
What is the duration of action of naltrexone after a single dose of 50 mg?
What is the analgesic potency of a 50-mg dose of pentazocine compared to codeine?
What is the analgesic potency of a 50-mg dose of pentazocine compared to codeine?
What is the purpose of including naloxone in the pentazocine tablet?
What is the purpose of including naloxone in the pentazocine tablet?
What is the result of structural simplification of the benzomorphan ring system?
What is the result of structural simplification of the benzomorphan ring system?
What is the characteristic of meperidine that indicates its analgesic activity?
What is the characteristic of meperidine that indicates its analgesic activity?
What is the primary use of diphenoxylate?
What is the primary use of diphenoxylate?
What is the effect of adding an electron withdrawing, lipophilic substituent in the para position of Phe4 on the activity?
What is the effect of adding an electron withdrawing, lipophilic substituent in the para position of Phe4 on the activity?
Which position of the peptide appears to tolerate more residue changes than the other positions?
Which position of the peptide appears to tolerate more residue changes than the other positions?
What is the result of the loss of the fifth residue to yield the tetrapeptide Tyr1-Gly2-Gly3-Phe4?
What is the result of the loss of the fifth residue to yield the tetrapeptide Tyr1-Gly2-Gly3-Phe4?
What is the class of opioid receptors?
What is the class of opioid receptors?
What is the effect of activating the opioid receptor?
What is the effect of activating the opioid receptor?
What is the full form of MOP in opioid receptor subtypes?
What is the full form of MOP in opioid receptor subtypes?
