Podcast
Questions and Answers
What is the primary mechanism by which the Gi-coupled MOR receptor decreases pain?
What is the primary mechanism by which the Gi-coupled MOR receptor decreases pain?
- Increasing the release of GABA
- Activating the opening of potassium channels
- Depolarizing the neuron
- Inhibiting the release of substance P (correct)
What is a common feature of the absorption of MOR opioids?
What is a common feature of the absorption of MOR opioids?
- High first-pass effect
- Extensive protein binding
- Rapid absorption from the gut (correct)
- Low lipophilicity
What is a medical use of delta opioids?
What is a medical use of delta opioids?
- Treatment of anxiety disorders
- Management of chronic pain (correct)
- Treatment of depression
- Relief of coughing
What is a disadvantage of MOR antagonists?
What is a disadvantage of MOR antagonists?
How does oxycodone compare to other mu opioids?
How does oxycodone compare to other mu opioids?
What is a physiological effect of meperidine?
What is a physiological effect of meperidine?
What are 2016 opioid prescription guidelines intended to address?
What are 2016 opioid prescription guidelines intended to address?
Which type of analgesia is reproduced by opioid analgesics?
Which type of analgesia is reproduced by opioid analgesics?
What is the mechanism of action of meperidine?
What is the mechanism of action of meperidine?
What enzyme converts codeine prodrugs?
What enzyme converts codeine prodrugs?
What side effects of mu opioids do not show tolerance?
What side effects of mu opioids do not show tolerance?
What patient population has a higher risk of deficient CYP2D6 metabolism?
What patient population has a higher risk of deficient CYP2D6 metabolism?
What medical use of mu opioids has no tolerance?
What medical use of mu opioids has no tolerance?
What is the mechanism that can counteract MOR opiate withdrawal?
What is the mechanism that can counteract MOR opiate withdrawal?
What is the enzyme that converts meperidine?
What is the enzyme that converts meperidine?
What is the primary function of the Gi-coupled MOR receptor in the context of pain relief?
What is the primary function of the Gi-coupled MOR receptor in the context of pain relief?
How do MOR agonists compare to MOR antagonists in terms of their effects on pain modulation?
How do MOR agonists compare to MOR antagonists in terms of their effects on pain modulation?
What is a key difference between codeine and oxycodone in terms of their pharmacokinetics?
What is a key difference between codeine and oxycodone in terms of their pharmacokinetics?
What is a common feature of the medical uses of mu opioids?
What is a common feature of the medical uses of mu opioids?
How do the physiological effects of meperidine compare to those of morphine?
How do the physiological effects of meperidine compare to those of morphine?
What is a key advantage of MOR agonists in the management of pain?
What is a key advantage of MOR agonists in the management of pain?
What is a side effect of mu opioids that does not show tolerance?
What is a side effect of mu opioids that does not show tolerance?
What type of drug therapy can provide equivalent pain relief as opioids?
What type of drug therapy can provide equivalent pain relief as opioids?
What is a situational advantage of MOR antagonists?
What is a situational advantage of MOR antagonists?
What is a characteristic of all neuroinhibitory MOR agonists?
What is a characteristic of all neuroinhibitory MOR agonists?
What is the primary mechanism of action of mu opioids?
What is the primary mechanism of action of mu opioids?
What factor can affect the choice of mu opioid drug?
What factor can affect the choice of mu opioid drug?
What is a side effect of mu opioids that shows tolerance?
What is a side effect of mu opioids that shows tolerance?
What is a contraindication for the use of meperidine?
What is a contraindication for the use of meperidine?
Why are kappa opioids not used medically?
Why are kappa opioids not used medically?
What is the primary mechanism by which mu opioids produce analgesia?
What is the primary mechanism by which mu opioids produce analgesia?
What is a key difference between morphine and oxycodone?
What is a key difference between morphine and oxycodone?
What is a common feature of the medical uses of mu opioids?
What is a common feature of the medical uses of mu opioids?
What is a disadvantage of MOR antagonists?
What is a disadvantage of MOR antagonists?
What is a feature of the absorption of MOR opioids?
What is a feature of the absorption of MOR opioids?
What is a medical use of codeine?
What is a medical use of codeine?
What is a side effect of mu opioids that shows tolerance?
What is a side effect of mu opioids that shows tolerance?
What type of analgesia is reproduced by kappa opioid analgesics?
What type of analgesia is reproduced by kappa opioid analgesics?
What is a common feature of the absorption of kappa opioids?
What is a common feature of the absorption of kappa opioids?
What is a medical use of mu opioids that has no tolerance?
What is a medical use of mu opioids that has no tolerance?
What is the mechanism of action of kappa opioids?
What is the mechanism of action of kappa opioids?
What is a characteristic of all neuroexcitatory MOR antagonists?
What is a characteristic of all neuroexcitatory MOR antagonists?
What is a contraindication for the use of meperidine?
What is a contraindication for the use of meperidine?
What is a factor that can affect the choice of mu opioid drug?
What is a factor that can affect the choice of mu opioid drug?
What is a side effect of mu opioids that shows tolerance?
What is a side effect of mu opioids that shows tolerance?
