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Questions and Answers
What is the primary mechanism through which the drug causes tachyphylaxis?
What is the primary mechanism through which the drug causes tachyphylaxis?
- Inhibition of norepinephrine reuptake
- Depletion of vesicles storing norepinephrine (NE) (correct)
- Enhanced receptor sensitivity
- Increased release of catecholamines
What is the absorption route for this synthetic non-catecholamine drug?
What is the absorption route for this synthetic non-catecholamine drug?
- Topical
- Intravenous
- Intramuscular
- Oral (correct)
Which of the following terms best describes the effect of tachyphylaxis?
Which of the following terms best describes the effect of tachyphylaxis?
- Reduction of response after repeated administration (correct)
- Enhanced drug effectiveness upon repeated doses
- Consistent response regardless of dosing frequency
- Increase in tolerance to the drug
Which of the following is NOT a characteristic of the drug described in the content?
Which of the following is NOT a characteristic of the drug described in the content?
What is the outcome of repeated administration of the drug mentioned?
What is the outcome of repeated administration of the drug mentioned?
What is a primary advantage of using the mentioned substance topically for cardiac conditions?
What is a primary advantage of using the mentioned substance topically for cardiac conditions?
In what scenario is the substance suggested to be particularly beneficial?
In what scenario is the substance suggested to be particularly beneficial?
What is a potential application of the substance mentioned in the context?
What is a potential application of the substance mentioned in the context?
What condition does the substance aim to address in connection with renal impairment?
What condition does the substance aim to address in connection with renal impairment?
Which aspect is most likely to hinder the use of the substance in surgical settings?
Which aspect is most likely to hinder the use of the substance in surgical settings?
Which of the following substances primarily acts as a selective agonist for β2 adrenergic receptors?
Which of the following substances primarily acts as a selective agonist for β2 adrenergic receptors?
What is the mechanism of action of Adrenaline when activating the α1 adrenergic receptors?
What is the mechanism of action of Adrenaline when activating the α1 adrenergic receptors?
What type of action does Midodrine primarily exhibit in the body?
What type of action does Midodrine primarily exhibit in the body?
Which of the following is NOT an action of Amphetamine?
Which of the following is NOT an action of Amphetamine?
Which of the following is true regarding the pharmacological classification of Midodrine?
Which of the following is true regarding the pharmacological classification of Midodrine?
Which of the following effects is least likely associated with Midodrine usage?
Which of the following effects is least likely associated with Midodrine usage?
Which drug would likely be used to induce uterine relaxation during preterm labor?
Which drug would likely be used to induce uterine relaxation during preterm labor?
Which synthetic compound is primarily known for its action as a selective α1 agonist?
Which synthetic compound is primarily known for its action as a selective α1 agonist?
How does Midodrine primarily facilitate its therapeutic effects?
How does Midodrine primarily facilitate its therapeutic effects?
What is a potential misconception regarding the therapeutic action of Midodrine?
What is a potential misconception regarding the therapeutic action of Midodrine?
What is the primary physiological effect of noradrenaline on heart rate when its action is greater on α receptors than β1 receptors?
What is the primary physiological effect of noradrenaline on heart rate when its action is greater on α receptors than β1 receptors?
Which receptor activation is primarily responsible for causing severe vasoconstriction in the context provided?
Which receptor activation is primarily responsible for causing severe vasoconstriction in the context provided?
What physiological response is typically associated with severe vasoconstriction?
What physiological response is typically associated with severe vasoconstriction?
In what state does the body find itself when there is a predominance of α1 receptor activation over β1 receptor effects?
In what state does the body find itself when there is a predominance of α1 receptor activation over β1 receptor effects?
What occurs to the heart rate when there is a forceful contraction of the heart induced by noradrenaline alongside vasoconstriction?
What occurs to the heart rate when there is a forceful contraction of the heart induced by noradrenaline alongside vasoconstriction?
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Study Notes
Drug Profile: Midodrine
- A dopaminergic drug primarily indicated for vasoconstriction without renal impairment effects.
- Preferred for its use in acute myocardial situations post-cardiac surgery.
Administration & Absorption
- Administered orally; classified as a synthetic non-catecholamine.
- Absorption allows for effective systemic delivery.
Mechanism of Action
- Acts on D1 receptors to promote vasoconstriction.
- Causes depletion of norepinephrine (NE) vesicles, impacting overall response.
Side Effects & Considerations
- May lead to tachyphylaxis, a phenomenon where response to the drug diminishes with repeated use.
- Consider reflex bradycardia as a notable side effect due to strong α1 receptor activity alongside vasoconstriction.
Related Compounds
- Other stimulants and sympathomimetics include Ephedrine, Amphetamine, Phenylephrine, Methoxamine, Salbutamol, and Ritodrine, each with varying receptor activity and effects.
- Noradrenaline primarily targets α-adrenergic receptors (α > β1), affecting contraction force while reducing heart rate.
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