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Questions and Answers
What is the action of Midodrine?
What is the action of Midodrine?
- Increases blood flow to the heart
- Activates alpha-receptors in arteries and veins (correct)
- Decreases vascular tone
- Lowers blood pressure
What is the indication for Midodrine?
What is the indication for Midodrine?
Symptomatic treatment of orthostatic hypotension
Describe the pharmacokinetics of Midodrine.
Describe the pharmacokinetics of Midodrine.
Absorbed from the GI tract, metabolized in the liver, and excreted in the urine
Which of the following are contraindications for Midodrine? (Select all that apply)
Which of the following are contraindications for Midodrine? (Select all that apply)
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What are some cautions associated with Midodrine?
What are some cautions associated with Midodrine?
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Adverse effects of Midodrine are related to stimulation of ______ receptors.
Adverse effects of Midodrine are related to stimulation of ______ receptors.
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Study Notes
Midodrine Overview
- Activates alpha-receptors in vascular tissues to enhance tone and elevate blood pressure.
Indication for Use
- Primarily used for symptomatic treatment of orthostatic hypotension, a condition causing dizziness or faintness upon standing.
Pharmacokinetics
- Absorption occurs via the gastrointestinal tract, followed by metabolism in the liver.
- Excretion is primarily through urine.
Contraindications
- Should not be used in patients with:
- Supine hypertension (elevated blood pressure while lying down)
- Coronary artery disease (CAD)
- Pheochromocytoma (tumor of the adrenal gland)
- Urinary retention (difficulty in urination)
Cautionary Considerations
- Use with caution in:
- Pregnant or breastfeeding individuals
- Patients with visual disturbances
Adverse Effects
- Adverse reactions linked to alpha-receptor stimulation include:
- Chills and rash
- Hypertension (HTN), bradycardia (slow heart rate)
- Dizziness and headache
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