Pharmacology of Local Anesthetics

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Questions and Answers

What factor can influence the duration of action of local anesthetics?

  • Tissue vascularity (correct)
  • Method of administration
  • Type of surgery
  • Patient's age

What is a common application of local anesthetics?

  • Dental procedures (correct)
  • General anesthesia
  • Organ transplantation
  • Neurosurgery

How do local anesthetics induce reversible loss of sensation in a specific area of the body?

  • By inhibiting the influx of sodium ions through voltage-gated sodium channels (correct)
  • By increasing the release of neurotransmitters from the nerve terminals
  • By blocking the efflux of potassium ions from neuronal cell membranes
  • By stimulating the activation of voltage-gated potassium channels

What is a potential systemic effect of local anesthetics?

<p>Hypotension (A)</p> Signup and view all the answers

What is the primary mechanism of metabolism for ester-linked local anesthetics?

<p>Hydrolysis (D)</p> Signup and view all the answers

What is a contraindication to local anesthetic use?

<p>Known hypersensitivity to the drug (A)</p> Signup and view all the answers

What is the common route of administration for local anesthetics?

<p>Topical application, infiltration, nerve block, or epidural/spinal injection (B)</p> Signup and view all the answers

Why is it important to monitor patients closely during and after administration of local anesthetics?

<p>To avoid systemic toxicity (D)</p> Signup and view all the answers

Which of the following local anesthetics is an ester-linked agent?

<p>Procaine (C)</p> Signup and view all the answers

What enzyme is involved in the metabolism of local anesthetics, and may be affected by drug interactions?

<p>CYP3A4 (B)</p> Signup and view all the answers

What is the effect of local anesthetics on neuronal cell membranes?

<p>They bind to specific receptor sites on the sodium channels (B)</p> Signup and view all the answers

What is the result of local anesthetics blocking the generation and propagation of action potentials?

<p>Loss of sensation in the region supplied by the affected nerves (C)</p> Signup and view all the answers

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