12 Questions
What factor can influence the duration of action of local anesthetics?
Tissue vascularity
What is a common application of local anesthetics?
Dental procedures
How do local anesthetics induce reversible loss of sensation in a specific area of the body?
By inhibiting the influx of sodium ions through voltage-gated sodium channels
What is a potential systemic effect of local anesthetics?
Hypotension
What is the primary mechanism of metabolism for ester-linked local anesthetics?
Hydrolysis
What is a contraindication to local anesthetic use?
Known hypersensitivity to the drug
What is the common route of administration for local anesthetics?
Topical application, infiltration, nerve block, or epidural/spinal injection
Why is it important to monitor patients closely during and after administration of local anesthetics?
To avoid systemic toxicity
Which of the following local anesthetics is an ester-linked agent?
Procaine
What enzyme is involved in the metabolism of local anesthetics, and may be affected by drug interactions?
CYP3A4
What is the effect of local anesthetics on neuronal cell membranes?
They bind to specific receptor sites on the sodium channels
What is the result of local anesthetics blocking the generation and propagation of action potentials?
Loss of sensation in the region supplied by the affected nerves
Test your knowledge on the mechanism of action of local anesthetics, how they block nerve conduction, and their effects on sodium channels in neuronal cell membranes. Learn about the pharmacology of local anesthetics and their role in inducing reversible loss of sensation.
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