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Questions and Answers
What is one way ion channels can be activated?
What is one way ion channels can be activated?
Which type of drug action is exemplified by ACE inhibitors?
Which type of drug action is exemplified by ACE inhibitors?
What characterizes active transporters?
What characterizes active transporters?
What is a key feature of false substrates like fluorouracil?
What is a key feature of false substrates like fluorouracil?
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How does the transport of organic molecules typically occur with inactive transport?
How does the transport of organic molecules typically occur with inactive transport?
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Study Notes
Ion Channels Activation
- Ion channels can be activated indirectly through G proteins and other intermediaries.
- The expression level of ion channels on the cell surface can be altered, impacting their function.
- Gabapentin is an example of a drug that reduces the insertion of neuronal calcium channels into the plasma membrane.
Enzymes
- Drugs can affect enzyme function in several ways:
- Competitive inhibition (e.g., ACEIs)
- Irreversible/non-competitive inhibition (e.g., Aspirin)
- Using false substrates (e.g., fluorouracil)
- Enzymes also play a role in drug actions:
- Drug activation (prodrug activation)
- Drug metabolism
Transporters
- Active transport relies on ATP and specific carriers (e.g., ABC transporters).
- In passive transport, solute carriers move molecules across membranes.
- Coupled transport, or co-transport, occurs when the movement of one molecule is dependent on the movement of another, in the same or opposite direction (e.g., symport, antiport).
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Description
Explore the mechanisms of ion channel activation, enzyme inhibition, and transporter functions in pharmacology. This quiz covers how drugs like Gabapentin and Aspirin interact with biological processes, affecting drug actions and metabolism. Test your knowledge on these crucial topics in drug pharmacodynamics.
