Pharmacology of Breast Cancer and Endometriosis Treatments
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Questions and Answers

What is the primary use of mifepristone (RU 486)?

  • Treatment of endometriosis
  • Controlled ovarian hyperstimulation
  • Abortifacient in early pregnancy (correct)
  • Suppression of gonadotropin secretion
  • Which drug is an irreversible aromatase inhibitor used in the treatment of breast cancer?

  • Danazol
  • Anastrozole
  • Exemestane (correct)
  • Letrozole
  • What is the primary mechanism of action of danazol?

  • Antagonist of progesterone and glucocorticoids
  • Suppresses gonadotropin secretion
  • Inhibits CYP450 involved in gonadal steroid synthesis (correct)
  • Irreversible aromatase inhibitor
  • Which drug class is used for controlled ovarian hyperstimulation?

    <p>Gonadotropin-releasing hormone antagonists</p> Signup and view all the answers

    Which of the following is true about testosterone?

    <p>It is synthesized from progesterone and DHEA</p> Signup and view all the answers

    What is the primary use of leuprolide?

    <p>Treatment of precocious puberty in children</p> Signup and view all the answers

    What is the mechanism of action of androgens?

    <p>Androgens enter the cell, bind to their receptor in the cytosol, and modulate gene expression in the nucleus</p> Signup and view all the answers

    Which of the following is NOT a clinical use of testosterone?

    <p>Treatment of benign prostatic hyperplasia (BPH)</p> Signup and view all the answers

    What is a potential toxicity of excessive testosterone in males?

    <p>Gynecomastia</p> Signup and view all the answers

    Which of the following is a nonsteroidal competitive androgen receptor blocker?

    <p>Bicalutamide</p> Signup and view all the answers

    What is the mechanism of action of $5\alpha$-reductase inhibitors like finasteride and dutasteride?

    <p>They inhibit the conversion of testosterone to dihydrotestosterone (DHT)</p> Signup and view all the answers

    Which of the following is used in the treatment of androgen-induced hirsutism in women?

    <p>Combined hormonal contraceptives</p> Signup and view all the answers

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