Pharmacology of Breast Cancer and Endometriosis Treatments

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What is the primary use of mifepristone (RU 486)?

Abortifacient in early pregnancy

Which drug is an irreversible aromatase inhibitor used in the treatment of breast cancer?

Exemestane

What is the primary mechanism of action of danazol?

Inhibits CYP450 involved in gonadal steroid synthesis

Which drug class is used for controlled ovarian hyperstimulation?

<p>Gonadotropin-releasing hormone antagonists</p> Signup and view all the answers

Which of the following is true about testosterone?

<p>It is synthesized from progesterone and DHEA</p> Signup and view all the answers

What is the primary use of leuprolide?

<p>Treatment of precocious puberty in children</p> Signup and view all the answers

What is the mechanism of action of androgens?

<p>Androgens enter the cell, bind to their receptor in the cytosol, and modulate gene expression in the nucleus</p> Signup and view all the answers

Which of the following is NOT a clinical use of testosterone?

<p>Treatment of benign prostatic hyperplasia (BPH)</p> Signup and view all the answers

What is a potential toxicity of excessive testosterone in males?

<p>Gynecomastia</p> Signup and view all the answers

Which of the following is a nonsteroidal competitive androgen receptor blocker?

<p>Bicalutamide</p> Signup and view all the answers

What is the mechanism of action of $5\alpha$-reductase inhibitors like finasteride and dutasteride?

<p>They inhibit the conversion of testosterone to dihydrotestosterone (DHT)</p> Signup and view all the answers

Which of the following is used in the treatment of androgen-induced hirsutism in women?

<p>Combined hormonal contraceptives</p> Signup and view all the answers

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