Pharmacology of Breast Cancer and Endometriosis Treatments

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Questions and Answers

What is the primary use of mifepristone (RU 486)?

  • Treatment of endometriosis
  • Controlled ovarian hyperstimulation
  • Abortifacient in early pregnancy (correct)
  • Suppression of gonadotropin secretion

Which drug is an irreversible aromatase inhibitor used in the treatment of breast cancer?

  • Danazol
  • Anastrozole
  • Exemestane (correct)
  • Letrozole

What is the primary mechanism of action of danazol?

  • Antagonist of progesterone and glucocorticoids
  • Suppresses gonadotropin secretion
  • Inhibits CYP450 involved in gonadal steroid synthesis (correct)
  • Irreversible aromatase inhibitor

Which drug class is used for controlled ovarian hyperstimulation?

<p>Gonadotropin-releasing hormone antagonists (A)</p> Signup and view all the answers

Which of the following is true about testosterone?

<p>It is synthesized from progesterone and DHEA (A)</p> Signup and view all the answers

What is the primary use of leuprolide?

<p>Treatment of precocious puberty in children (D)</p> Signup and view all the answers

What is the mechanism of action of androgens?

<p>Androgens enter the cell, bind to their receptor in the cytosol, and modulate gene expression in the nucleus (D)</p> Signup and view all the answers

Which of the following is NOT a clinical use of testosterone?

<p>Treatment of benign prostatic hyperplasia (BPH) (C)</p> Signup and view all the answers

What is a potential toxicity of excessive testosterone in males?

<p>Gynecomastia (D)</p> Signup and view all the answers

Which of the following is a nonsteroidal competitive androgen receptor blocker?

<p>Bicalutamide (C)</p> Signup and view all the answers

What is the mechanism of action of $5\alpha$-reductase inhibitors like finasteride and dutasteride?

<p>They inhibit the conversion of testosterone to dihydrotestosterone (DHT) (A)</p> Signup and view all the answers

Which of the following is used in the treatment of androgen-induced hirsutism in women?

<p>Combined hormonal contraceptives (A)</p> Signup and view all the answers

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