Pharmacology of Blood Lipids
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Questions and Answers

Which lipoprotein is the main carrier of cholesterol?

  • IDL
  • VLDL
  • LDL (correct)
  • Chylomicrons

What is the function of lipoprotein lipase (LPL)?

  • Transporting cholesterol to the liver
  • Facilitating cholesterol uptake by cells
  • Hydrolyzing triglycerides (correct)
  • Synthesizing lipoproteins

Which lipoprotein is responsible for the reverse transport of cholesterol to the liver?

  • HDL (correct)
  • VLDL
  • IDL
  • LDL

What is the most frequent cause of hyperlipidemia?

<p>Dietary excess (D)</p> Signup and view all the answers

Which type of hyperlipidemia is characterized by elevated triglycerides and cholesterol?

<p>Type IIb (A)</p> Signup and view all the answers

What is the function of bile acids in the body?

<p>Modulating cholesterol levels (C)</p> Signup and view all the answers

Which lipoprotein is responsible for transporting triglycerides to adipose tissue, heart, and skeletal muscle?

<p>VLDL (D)</p> Signup and view all the answers

What is the main component of the core of lipoproteins?

<p>Triglycerides (B)</p> Signup and view all the answers

Which lipoprotein is synthesized in the intestine?

<p>Chylomicrons (D)</p> Signup and view all the answers

Which lipoprotein is responsible for cholesterol uptake by cells?

<p>LDL (A)</p> Signup and view all the answers

Which enzyme catalyzes the rate limiting step of hepatic cholesterol synthesis?

<p>HMG-CoA reductase (C)</p> Signup and view all the answers

What is the main content of LDL (low-density lipoprotein)?

<p>Cholesterol esters (B)</p> Signup and view all the answers

Which lipoprotein carries the apolipoprotein B-100 and binds to receptors of target organs for cholesterol uptake?

<p>LDL (B)</p> Signup and view all the answers

What is the density range of VLDL (very low-density lipoprotein)?

<p>0.950-1.006 g/mL (C)</p> Signup and view all the answers

Which lipoprotein originates from the liver?

<p>VLDL (A)</p> Signup and view all the answers

What is the main function of triglycerides (TGs)?

<p>Storing energy (A)</p> Signup and view all the answers

Which class of drugs is used to lower triglyceride and/or cholesterol blood levels?

<p>Hypolipidemic drugs (D)</p> Signup and view all the answers

What is the main building block of biological membranes and steroid hormones?

<p>Cholesterol (C)</p> Signup and view all the answers

Which lipoprotein transports cholesterol from tissue cells back to the liver?

<p>HDL (D)</p> Signup and view all the answers

What is the rate limiting step of hepatic cholesterol synthesis?

<p>HMG-CoA reductase (D)</p> Signup and view all the answers

Which of the following drugs inhibits the Niemann-Pick C1-Like1 (NPC1L1) cholesterol transporter?

<p>Ezetimibe (C)</p> Signup and view all the answers

What is the maximal effect of bile acid sequestering resins drugs on blood LDL cholesterol?

<p>20% reduction (B)</p> Signup and view all the answers

Which adverse effect is associated with cholestyramine use?

<p>Bloating (D)</p> Signup and view all the answers

Which drug is used as an adjunct to diet to reduce triglyceride levels in adults with severe hypertriglyceridemia?

<p>Icosapent ethyl (B)</p> Signup and view all the answers

Which class of drugs has the greatest reduction in LDL cholesterol?

<p>HMG-CoA reductase inhibitors (A)</p> Signup and view all the answers

Which adverse effect is associated with HMG-CoA reductase inhibitors?

<p>Rhabdomyolysis (D)</p> Signup and view all the answers

Which drug can be used as monotherapy if statins are not tolerated?

<p>Ezetimibe (D)</p> Signup and view all the answers

Which drug can be combined with ezetimibe to lower LDL cholesterol even more?

<p>HMG-CoA reductase inhibitors (D)</p> Signup and view all the answers

Which drug has the main effect of reducing hepatic production of triglyceride-rich VLDL?

<p>Icosapent ethyl (D)</p> Signup and view all the answers

Which drug is used as an adjunct to maximally tolerated statin therapy in adult patients with TG levels >150 mg/dL and two or more risk factors for cardiovascular disease?

<p>Icosapent ethyl (C)</p> Signup and view all the answers

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