30 Questions
Which lipoprotein is the main carrier of cholesterol?
LDL
What is the function of lipoprotein lipase (LPL)?
Hydrolyzing triglycerides
Which lipoprotein is responsible for the reverse transport of cholesterol to the liver?
HDL
What is the most frequent cause of hyperlipidemia?
Dietary excess
Which type of hyperlipidemia is characterized by elevated triglycerides and cholesterol?
Type IIb
What is the function of bile acids in the body?
Modulating cholesterol levels
Which lipoprotein is responsible for transporting triglycerides to adipose tissue, heart, and skeletal muscle?
VLDL
What is the main component of the core of lipoproteins?
Triglycerides
Which lipoprotein is synthesized in the intestine?
Chylomicrons
Which lipoprotein is responsible for cholesterol uptake by cells?
LDL
Which enzyme catalyzes the rate limiting step of hepatic cholesterol synthesis?
HMG-CoA reductase
What is the main content of LDL (low-density lipoprotein)?
Cholesterol esters
Which lipoprotein carries the apolipoprotein B-100 and binds to receptors of target organs for cholesterol uptake?
LDL
What is the density range of VLDL (very low-density lipoprotein)?
0.950-1.006 g/mL
Which lipoprotein originates from the liver?
VLDL
What is the main function of triglycerides (TGs)?
Storing energy
Which class of drugs is used to lower triglyceride and/or cholesterol blood levels?
Hypolipidemic drugs
What is the main building block of biological membranes and steroid hormones?
Cholesterol
Which lipoprotein transports cholesterol from tissue cells back to the liver?
HDL
What is the rate limiting step of hepatic cholesterol synthesis?
HMG-CoA reductase
Which of the following drugs inhibits the Niemann-Pick C1-Like1 (NPC1L1) cholesterol transporter?
Ezetimibe
What is the maximal effect of bile acid sequestering resins drugs on blood LDL cholesterol?
20% reduction
Which adverse effect is associated with cholestyramine use?
Bloating
Which drug is used as an adjunct to diet to reduce triglyceride levels in adults with severe hypertriglyceridemia?
Icosapent ethyl
Which class of drugs has the greatest reduction in LDL cholesterol?
HMG-CoA reductase inhibitors
Which adverse effect is associated with HMG-CoA reductase inhibitors?
Rhabdomyolysis
Which drug can be used as monotherapy if statins are not tolerated?
Ezetimibe
Which drug can be combined with ezetimibe to lower LDL cholesterol even more?
HMG-CoA reductase inhibitors
Which drug has the main effect of reducing hepatic production of triglyceride-rich VLDL?
Icosapent ethyl
Which drug is used as an adjunct to maximally tolerated statin therapy in adult patients with TG levels >150 mg/dL and two or more risk factors for cardiovascular disease?
Icosapent ethyl
Test your knowledge of pharmacology of blood lipids with this informative quiz. Learn about the classes of drugs used to lower triglyceride and cholesterol levels, their mechanisms of action, potential adverse effects, drug interactions, and contraindications. Challenge yourself and enhance your understanding of hypolipidemic medications.
Make Your Own Quizzes and Flashcards
Convert your notes into interactive study material.
Get started for free
