Pharmacology of Beta Receptors

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Questions and Answers

What is the effect of stimulating α2-receptors on blood pressure?

  • No change
  • Decrease (correct)
  • Initial decrease followed by increase
  • Increase

What is the effect of β2 receptors on respiratory smooth muscle?

  • Relaxation (correct)
  • Constriction
  • Depends on dose
  • No change

What is the effect of dopamine on heart rate at low doses?

  • Decrease (correct)
  • Increase
  • Biphasic response
  • No change

What is the primary mechanism of epinephrine's effect on coronary blood flow?

<p>Increased myocardial oxygen demand (C)</p> Signup and view all the answers

What is the primary effect of β1-receptors on the heart?

<p>Positive chronotropy and inotropy (C)</p> Signup and view all the answers

What is the half-life of elimination of epinephrine?

<p>&lt; 5 minutes (C)</p> Signup and view all the answers

What is the effect of norepinephrine on heart rate?

<p>Maintained (A)</p> Signup and view all the answers

What is the primary mechanism of dopamine's indirect effects?

<p>Release of norepinephrine (D)</p> Signup and view all the answers

What is the effect of isoproterenol on myocardial O2 supply?

<p>Decreased (D)</p> Signup and view all the answers

What is the primary effect of dobutamine on the heart?

<p>Increased coronary blood flow (A)</p> Signup and view all the answers

What is the mechanism of norepinephrine's vasoconstrictor effect?

<p>Activation of α1 receptors (B)</p> Signup and view all the answers

What is the effect of dopamine on peripheral vascular resistance at high doses?

<p>Increased (D)</p> Signup and view all the answers

What is the primary effect of β1 agonists on the heart?

<p>Increase cardiac contractility (C)</p> Signup and view all the answers

What is the mechanism of action of ephedrine?

<p>Indirect β agonist and direct α agonist (C)</p> Signup and view all the answers

What is the primary effect of phenylephrine on the heart?

<p>Decrease heart rate (C)</p> Signup and view all the answers

What is the primary mechanism of action of phentolamine?

<p>Competitive and nonselective α antagonist (B)</p> Signup and view all the answers

What is the typical dose range for dopamine infusion?

<p>0.5-1 mcg/kg/min (C)</p> Signup and view all the answers

What is the primary use of phenylephrine nasal drops/spray?

<p>To vasoconstrict nares prior to nasal intubation (A)</p> Signup and view all the answers

What is the primary effect of phenoxybenzamine on blood pressure?

<p>It causes a decrease in blood pressure (B)</p> Signup and view all the answers

What is the main use of yohimbine?

<p>Treatment of orthostatic hypotension (D)</p> Signup and view all the answers

What is the FDA warning associated with droperidol?

<p>Prolonged QT interval (C)</p> Signup and view all the answers

What is the effect of clonidine on heart rate?

<p>It decreases heart rate in a dose-dependent manner (A)</p> Signup and view all the answers

What is the main mechanism of action of dexmedetomidine?

<p>It is a selective presynaptic α2 agonist (B)</p> Signup and view all the answers

What is the effect of phenoxybenzamine on insulin secretion?

<p>It increases insulin secretion (A)</p> Signup and view all the answers

What is the primary indication for initiating β blockade preoperatively?

<p>Vascular and intermediate-risk surgical procedures (D)</p> Signup and view all the answers

What is the primary advantage of using cardioselective β blockers?

<p>They are more selective for β1 receptors (C)</p> Signup and view all the answers

What is the effect of β blockers on the sympathetic nervous system?

<p>Decrease sympathetic nervous system activity (B)</p> Signup and view all the answers

What is the dose of esmolol for controlling heart rate?

<p>10-20 mg initial and titrate to goal HR (D)</p> Signup and view all the answers

What is the mechanism of labetalol's action?

<p>Non-selective β and α1 antagonist (C)</p> Signup and view all the answers

What is the antidote for β blocker overdose?

<p>Glucagon 5 mg IV (A)</p> Signup and view all the answers

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