Pharmacology of Barbiturates

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Questions and Answers

What is the primary mechanism of action of benzodiazepines?

  • Blocking the effects of GABA
  • Increasing the effects of GABA (correct)
  • Inhibiting the release of dopamine
  • Activating the chloride channel for a short period

What is the primary therapeutic use of barbiturates?

  • To treat insomnia and prepare patients for surgery (correct)
  • To treat depression
  • To treat ADHD
  • To treat anxiety disorders

What is a common adverse effect of barbiturates on the respiratory system?

  • Tachycardia
  • Respiratory stimulation
  • Hypertension
  • Respiratory depression (correct)

What is the primary difference between benzodiazepines and non-benzodiazepines?

<p>Benzodiazepines have a different mechanism of action (A)</p> Signup and view all the answers

Why do the effects of barbiturates diminish after approximately 2 weeks?

<p>Because the patient develops tolerance (A)</p> Signup and view all the answers

What is the effect of chloride ions entering the cell when barbiturates and benzodiazepine are given together?

<p>Nerve impulse transmission is totally stopped (D)</p> Signup and view all the answers

What is the mechanism of action of non-benzodiazepine anxiolytics?

<p>They block the receptors on the brain (D)</p> Signup and view all the answers

What is the primary therapeutic use of benzodiazepines?

<p>Treatment of anxiety disorders (A)</p> Signup and view all the answers

What is a common adverse reaction of benzodiazepines?

<p>Fatigue (B)</p> Signup and view all the answers

What is the primary characteristic of depression?

<p>Feelings of intense sadness (D)</p> Signup and view all the answers

Which neurotransmitter is facilitated by barbiturates to inhibit impulse transmission?

<p>GABA (D)</p> Signup and view all the answers

What is the primary effect of sedatives on a patient?

<p>Produce a relaxing and calming effect (A)</p> Signup and view all the answers

What is the main difference between hypnotics and sedatives?

<p>Hypnotics induce sleep, while sedatives do not (A)</p> Signup and view all the answers

What is the duration of action of long-acting barbiturates?

<p>10 to 16 hours (A)</p> Signup and view all the answers

What is the result of increased chloride ion influx due to barbiturates?

<p>Inhibition of impulse transmission (B)</p> Signup and view all the answers

What happens when antidepressants block the reuptake of endogenous neurotransmitters?

<p>CNS stimulation occurs and the patient becomes excited and relieved from depression (A)</p> Signup and view all the answers

What is a common mechanism of action of tricyclic antidepressants (TCAs)?

<p>Inhibiting the uptake of norepinephrine and serotonin into the same neuron (A)</p> Signup and view all the answers

What is the mechanism of action of some antidepressants that inhibit enzymes that destroy neurotransmitters?

<p>Decreasing the breakdown of neurotransmitters (D)</p> Signup and view all the answers

What is the mechanism of action of selective serotonin reuptake inhibitors (SSRIs)?

<p>Inhibiting the uptake of serotonin into the same neuron (D)</p> Signup and view all the answers

What is the overall effect of antidepressants on neurotransmitters?

<p>Increasing the amount of neurotransmitters available (D)</p> Signup and view all the answers

Which of the following neurotransmitters is involved in movement, attention, and emotion?

<p>Dopamine (D)</p> Signup and view all the answers

What is the effect of a deficiency of Serotonin?

<p>Depression (C)</p> Signup and view all the answers

Which of the following is a type of agent used to treat anxiety disorders?

<p>Anti-anxiety (C)</p> Signup and view all the answers

What is the effect of a deficiency of Norepinephrine?

<p>Depression (B)</p> Signup and view all the answers

What is the primary role of Hypnotics and Sedatives?

<p>To induce sleep (C)</p> Signup and view all the answers

What is the primary effect of local anesthesia on the patient?

<p>The patient feels no pain in a specific area (A)</p> Signup and view all the answers

What is the primary difference between general anesthesia and local anesthesia?

<p>General anesthesia results in loss of sensation of the entire body, while local anesthesia results in loss of sensation in a specific area (A)</p> Signup and view all the answers

What is the mechanism of action of topical anesthesia?

<p>The anesthetic drug is applied to the surface of skin and mucous membrane (D)</p> Signup and view all the answers

What is the primary difference between regional anesthesia and local infiltration anesthesia?

<p>Regional anesthesia involves injection around nerves, while local infiltration anesthesia involves injection into tissues (C)</p> Signup and view all the answers

What is the primary effect of general anesthesia on a patient?

<p>The patient is unconscious and feels no pain (A)</p> Signup and view all the answers

What is the result of destroying enzymes in impulse transmission?

<p>CNS stimulation (B)</p> Signup and view all the answers

Which enzyme is inhibited by Monoamine Oxidase Inhibitors (MAOIs)?

<p>Monoamine Oxidase (D)</p> Signup and view all the answers

What is a therapeutic use of Monoamine Oxidase Inhibitors (MAOIs)?

<p>All of the above (D)</p> Signup and view all the answers

What is a possible adverse reaction of Monoamine Oxidase Inhibitors (MAOIs)?

<p>All of the above (D)</p> Signup and view all the answers

Which neurotransmitters are involved in impulse transmission?

<p>Monoamine (A)</p> Signup and view all the answers

What is the effect of destroying enzymes in neurotransmission?

<p>Relief from depression (B)</p> Signup and view all the answers

Which of the following is NOT a therapeutic use of MAOIs?

<p>Lowering blood pressure (D)</p> Signup and view all the answers

What is the result of MAOI therapy?

<p>Increased Monoamine neurotransmitters (D)</p> Signup and view all the answers

What is a possible cause of nausea and vomiting in MAOI therapy?

<p>Increase in Monoamine neurotransmitters (C)</p> Signup and view all the answers

Which of the following is a common adverse reaction of MAOIs?

<p>All of the above (D)</p> Signup and view all the answers

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