18 Questions
What happens to highly lipid soluble barbiturates and benzodiazepines after they are distributed into the body?
Redistribution to peripheral tissue occurs
What is the mechanism of action of Barbiturates?
By enhancing the GABA receptor activity
What is the mechanism of action of barbiturates and benzodiazepines?
They have an allosteric effect that facilitates the GABA action
How are barbiturates and benzodiazepines excreted from the body?
Through the kidneys
How do Benzodiazepines differ from Barbiturates in terms of their chemistry?
All members of Benzodiazepines contain fusion of benzine and diazepine rings
What happens to barbiturates in the liver?
They are oxidized into inactive metabolites
What is the duration of action of Ultrashort Acting Barbiturates?
Immediate to 20 minutes
What is the general anesthetic effect of Sedative-Hypnotics?
Coma
How are barbiturates and benzodiazepines absorbed into the body?
They are absorbed well from the GIT, except for Thiopental
What is the effect of phenobarbitone on microsomal enzymes?
It induces microsomal enzymes
Which of the following is an Intermediate Acting Benzodiazepine?
Temazepam
What is the onset of action of Remimazolam?
Immediate
What is the consequence of the body adapting to the continued presence of Barbiturates and Benzodiazepines due to decreased sensitivity of GABA receptors?
Tolerance
What is the consequence of suddenly stopping or reducing the dosage of Barbiturates and Benzodiazepines?
Physical Dependence
What is the contraindication for Barbiturates and Benzodiazepines in patients with acute narrow angle glaucoma?
Acute narrow angle glaucoma
What is the specific antagonist for Benzodiazepines overdose?
Flumazenil
What is the mechanism of action of Flumazenil?
Blocking the action of Benzodiazepines on GABA receptors
What is the characteristic of Flumazenil's molecular structure?
Similar to that of all Benzos
Compare and contrast the pharmacokinetics and pharmacodynamics of barbiturates and benzodiazepines, including absorption, distribution, and metabolism. Learn about the onset and prototype of these medications.
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