Recent Lessons

Show all results for ""

Feature Overview

Ace your exams with our all-in-one platform for creating and sharing quizzes and tests.

Quizzes

Create quizzes and tests automatically from your content using AI.

Flashcards

Automatically turn your notes into digital flashcards.

Share, Export & Embed

Share with classmates or export to Excel and your learning management system.

Stats & Reporting

Auto-grading quizzes and tests with detailed stats and reports.

Mobile Apps

The smarter way to study – wherever you are.

Pricing

Search...

Pharmacology: Anxiolytic and Hypnotic Drugs

6 Questions

0 Views

Pharmacology: Anxiolytic and Hypnotic Drugs

Choose a study mode

Play Quiz

Study Flashcards

Spaced Repetition

Chat to lesson

Podcast

Play an AI-generated podcast conversation about this lesson

Questions and Answers

Where do benzodiazepines bind on the GABA extsubscript{A} receptor?

At a high-affinity site at the interface of the $eta$ and $eta$ subunits

At the GABA-binding site between the $eta$ and $ heta$ subunits

At a specific, high-affinity site at the interface of the $ extalpha$ subunit and the $ extgamma$ subunit (correct)

At a specific, high-affinity site at the interface of the $eta$ subunit and the $ heta$ subunit

What is one mechanism through which benzodiazepines produce anxiolytic effects at low doses?

By stimulating the release of GABA from presynaptic neurons in the cortex

By enhancing GABAergic transmission in neurons having the $ extalpha_2$ subunit in their GABA extsubscript{A} receptors (correct)

By reducing the synthesis of GABA in the limbic system

By inhibiting $ extalpha_1$ subunits in the GABA extsubscript{A} receptors in the motor cortex

What is the main action of benzodiazepines on chloride ion channels?

Increasing the frequency of channel openings produced by GABA (correct)

Increasing the amount of chloride that binds to the ion channel

Blocking the ion channel to prevent chloride from passing through

Decreasing the passage of chloride ions through the channel

What designations are given to common BZ receptor subtypes in the CNS?

BZ extsubscript{1} and BZ extsubscript{2} Signup and view all the answers

How do benzodiazepines affect the affinity of GABA for its binding site?

They increase the affinity of GABA for the binding site Signup and view all the answers

Which part of the brain is most involved in the anxiolytic effects of benzodiazepines?

Limbic system Signup and view all the answers

Study Notes

Anxiolytic and Hypnotic Drugs

Benzodiazepines modulate GABA effects by binding to a specific, high-affinity site on the GABA(_A) receptor, located at the interface of the α subunit and the γ subunit.

Mechanism of Action

Benzodiazepines increase the frequency of channel openings produced by GABA.
Binding of a benzodiazepine to its receptor site increases the affinity of GABA for the GABA-binding site (and vice versa).

BZD Receptor Subtypes

BZ(_1) subtype: includes an α(_1) subunit.
BZ(_2) subtype: includes an α(_2) subunit.

Clinical Effects

The clinical effects of benzodiazepines correlate well with the binding affinity of each drug for the GABA receptor–chloride ion channel complex.

Actions of Benzodiazepines

Reduction of anxiety: anxiolytic effects at low doses.
Mechanism of anxiolytic action: selectively enhancing GABAergic transmission in neurons having the α(_2) subunit in their GABA(_A) receptors, thereby inhibiting neuronal circuits in the limbic system of the brain.